MicroRNAs in Development
Over 10 years ago, the lab of Victor Ambros cloned an unusual gene, lin-4, which encodes two small RNA transcripts[1]. In the past few years, hundreds more of these tiny transcripts, termed microRNAs (miRNAs), have been uncovered in over a dozen species. The functions of the first two miRNAs, lin-4...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.313 |
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| _version_ | 1832558270689050624 |
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| author | Danielle Maatouk Brian D. Harfe |
| author_facet | Danielle Maatouk Brian D. Harfe |
| author_sort | Danielle Maatouk |
| collection | DOAJ |
| description | Over 10 years ago, the lab of Victor Ambros cloned an unusual gene, lin-4, which encodes two small RNA transcripts[1]. In the past few years, hundreds more of these tiny transcripts, termed microRNAs (miRNAs), have been uncovered in over a dozen species. The functions of the first two miRNAs, lin-4 and let-7, were relatively easy to identify since they were found in forward genetic screens in Caenorhabditis elegans[1,2,3]. However, uncovering the functions of the growing list of miRNAs presents a challenge to developmental biologists. This review will describe our current understanding of how miRNAs regulate gene expression and will focus on the roles these noncoding RNAs play during the development of both invertebrate and vertebrate species. |
| format | Article |
| id | doaj-art-bd08b6c8423a43ca9ac27e7f941806b6 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-bd08b6c8423a43ca9ac27e7f941806b62025-02-03T01:32:53ZengWileyThe Scientific World Journal1537-744X2006-01-0161828184010.1100/tsw.2006.313MicroRNAs in DevelopmentDanielle Maatouk0Brian D. Harfe1University of Florida College of Medicine, Department of Molecular Genetics and Microbiology, Gainesville, FL 32610, USAUniversity of Florida College of Medicine, Department of Molecular Genetics and Microbiology, Gainesville, FL 32610, USAOver 10 years ago, the lab of Victor Ambros cloned an unusual gene, lin-4, which encodes two small RNA transcripts[1]. In the past few years, hundreds more of these tiny transcripts, termed microRNAs (miRNAs), have been uncovered in over a dozen species. The functions of the first two miRNAs, lin-4 and let-7, were relatively easy to identify since they were found in forward genetic screens in Caenorhabditis elegans[1,2,3]. However, uncovering the functions of the growing list of miRNAs presents a challenge to developmental biologists. This review will describe our current understanding of how miRNAs regulate gene expression and will focus on the roles these noncoding RNAs play during the development of both invertebrate and vertebrate species.http://dx.doi.org/10.1100/tsw.2006.313 |
| spellingShingle | Danielle Maatouk Brian D. Harfe MicroRNAs in Development The Scientific World Journal |
| title | MicroRNAs in Development |
| title_full | MicroRNAs in Development |
| title_fullStr | MicroRNAs in Development |
| title_full_unstemmed | MicroRNAs in Development |
| title_short | MicroRNAs in Development |
| title_sort | micrornas in development |
| url | http://dx.doi.org/10.1100/tsw.2006.313 |
| work_keys_str_mv | AT daniellemaatouk micrornasindevelopment AT briandharfe micrornasindevelopment |