Interpretation of Hormone Levels in Older Patients: Points for Consideration
Blood hormone and tumor marker concentrations are usually determined by immunochemical methods which are based on an unique reaction between antigen and assay capture antibody. Despite the speed and simplicity of assays performance on automatic immunochemistry platforms, the interpretation of final...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/712425 |
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| _version_ | 1832551488248872960 |
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| author | Krystyna Sztefko Patrycja Szybowska |
| author_facet | Krystyna Sztefko Patrycja Szybowska |
| author_sort | Krystyna Sztefko |
| collection | DOAJ |
| description | Blood hormone and tumor marker concentrations are usually determined by immunochemical methods which are based on an unique reaction between antigen and assay capture antibody. Despite the speed and simplicity of assays performance on automatic immunochemistry platforms, the interpretation of final results requires a deep knowledge of method fallibility. General lack of immunoassays standardization, presence of cross-reacting substances in patient’s sample, limitation of free hormones measurement due to abnormal analyte binding protein concentrations, assay interferences due to patient’s autoantibodies, and heterophilic antibodies, as well as proper interpretation of very low- and very high-sample analyte levels, are the main points discussed in respect to hormones and tumor markers measurement in geriatric population. |
| format | Article |
| id | doaj-art-bd053f3ded654f5fa29aa16570a224b7 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-bd053f3ded654f5fa29aa16570a224b72025-02-03T06:01:24ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/712425712425Interpretation of Hormone Levels in Older Patients: Points for ConsiderationKrystyna Sztefko0Patrycja Szybowska1Clinical Biochemistry Department, College of Medicine, Jagiellonian University, Wielicka Street 265, 30-663 Kracow, PolandClinical Biochemistry Department, College of Medicine, Jagiellonian University, Wielicka Street 265, 30-663 Kracow, PolandBlood hormone and tumor marker concentrations are usually determined by immunochemical methods which are based on an unique reaction between antigen and assay capture antibody. Despite the speed and simplicity of assays performance on automatic immunochemistry platforms, the interpretation of final results requires a deep knowledge of method fallibility. General lack of immunoassays standardization, presence of cross-reacting substances in patient’s sample, limitation of free hormones measurement due to abnormal analyte binding protein concentrations, assay interferences due to patient’s autoantibodies, and heterophilic antibodies, as well as proper interpretation of very low- and very high-sample analyte levels, are the main points discussed in respect to hormones and tumor markers measurement in geriatric population.http://dx.doi.org/10.1155/2012/712425 |
| spellingShingle | Krystyna Sztefko Patrycja Szybowska Interpretation of Hormone Levels in Older Patients: Points for Consideration International Journal of Endocrinology |
| title | Interpretation of Hormone Levels in Older Patients: Points for Consideration |
| title_full | Interpretation of Hormone Levels in Older Patients: Points for Consideration |
| title_fullStr | Interpretation of Hormone Levels in Older Patients: Points for Consideration |
| title_full_unstemmed | Interpretation of Hormone Levels in Older Patients: Points for Consideration |
| title_short | Interpretation of Hormone Levels in Older Patients: Points for Consideration |
| title_sort | interpretation of hormone levels in older patients points for consideration |
| url | http://dx.doi.org/10.1155/2012/712425 |
| work_keys_str_mv | AT krystynasztefko interpretationofhormonelevelsinolderpatientspointsforconsideration AT patrycjaszybowska interpretationofhormonelevelsinolderpatientspointsforconsideration |