Tumor Site‐Specific In Vivo Theranostics Enabled by Microenvironment‐Dependent Chemical Transformation and Self‐Amplifying Effect
Abstract Precise tumor diagnosis and treatment remain complex challenges. While numerous fluorescent probes have been developed for tumor‐specific imaging and therapy, few exhibit effective function in vivo. Herein, a probe called TQ‐H2 is designed that can realize robust theranostic effects both in...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202409506 |
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| author | Yunfei Zuo Pei Li Wen‐Jin Wang Changhuo Xu Shuting Xu Herman H. Y. Sung Jianwei Sun Guorui Jin Weiping Wang Ryan T. K. Kwok Jacky W. Y. Lam Ben Zhong Tang |
| author_facet | Yunfei Zuo Pei Li Wen‐Jin Wang Changhuo Xu Shuting Xu Herman H. Y. Sung Jianwei Sun Guorui Jin Weiping Wang Ryan T. K. Kwok Jacky W. Y. Lam Ben Zhong Tang |
| author_sort | Yunfei Zuo |
| collection | DOAJ |
| description | Abstract Precise tumor diagnosis and treatment remain complex challenges. While numerous fluorescent probes have been developed for tumor‐specific imaging and therapy, few exhibit effective function in vivo. Herein, a probe called TQ‐H2 is designed that can realize robust theranostic effects both in vitro and in vivo. In vitro, TQ‐H2 specifically targets the lysosome and reacts with hydroxyl radical (·OH) to generate TQ‐HA, which lights up the cells. TQ‐HA generates reactive oxygen species (ROS) under light irradiation, enabling the simultaneous induction and monitoring of apoptosis and ferroptosis in tumor cells. Remarkably, TQ‐HA also acts as a self‐amplifier, autocatalytically activating TQ‐H2 by generating ·OH under light exposure. This self‐amplification aligns with the tumor microenvironment, where TQ‐H2 undergoes chemical transformation, distinguishing tumors from healthy tissue via near‐infrared (NIR) fluorescence imaging. Furthermore, ROS generated by TQ‐HA effectively kills tumor cells and inhibits tumor growth without harming normal cells. This study offers a promising strategy for targeted tumor theranostics using self‐amplifying microenvironment‐responsive fluorescent probes. |
| format | Article |
| id | doaj-art-bd0377b9fd8a48b3806044f8f73f4ca7 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-bd0377b9fd8a48b3806044f8f73f4ca72025-01-29T09:50:18ZengWileyAdvanced Science2198-38442025-01-01124n/an/a10.1002/advs.202409506Tumor Site‐Specific In Vivo Theranostics Enabled by Microenvironment‐Dependent Chemical Transformation and Self‐Amplifying EffectYunfei Zuo0Pei Li1Wen‐Jin Wang2Changhuo Xu3Shuting Xu4Herman H. Y. Sung5Jianwei Sun6Guorui Jin7Weiping Wang8Ryan T. K. Kwok9Jacky W. Y. Lam10Ben Zhong Tang11Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science State Key Laboratory of Molecular Neuroscience and Department of Chemical and Biological Engineering The Hong Kong University of Science & Technology Clear Water Bay Kowloon Hong Kong 999077 P. R. ChinaDepartment of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science State Key Laboratory of Molecular Neuroscience and Department of Chemical and Biological Engineering The Hong Kong University of Science & Technology Clear Water Bay Kowloon Hong Kong 999077 P. R. ChinaChina Clinical Translational Research Center of Aggregation‐Induced Emission The Second Affiliated Hospital School of Medicine School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen (CUHK‐Shenzhen) Guangdong 518172 ChinaMOE Frontiers Science Center for Precision Oncology Faculty of Health Sciences University of Macau Macao 999078 ChinaDepartment of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong 999077 ChinaDepartment of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science State Key Laboratory of Molecular Neuroscience and Department of Chemical and Biological Engineering The Hong Kong University of Science & Technology Clear Water Bay Kowloon Hong Kong 999077 P. R. ChinaDepartment of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science State Key Laboratory of Molecular Neuroscience and Department of Chemical and Biological Engineering The Hong Kong University of Science & Technology Clear Water Bay Kowloon Hong Kong 999077 P. R. ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an 710049 ChinaDepartment of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong 999077 ChinaDepartment of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science State Key Laboratory of Molecular Neuroscience and Department of Chemical and Biological Engineering The Hong Kong University of Science & Technology Clear Water Bay Kowloon Hong Kong 999077 P. R. ChinaDepartment of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science State Key Laboratory of Molecular Neuroscience and Department of Chemical and Biological Engineering The Hong Kong University of Science & Technology Clear Water Bay Kowloon Hong Kong 999077 P. R. ChinaDepartment of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science State Key Laboratory of Molecular Neuroscience and Department of Chemical and Biological Engineering The Hong Kong University of Science & Technology Clear Water Bay Kowloon Hong Kong 999077 P. R. ChinaAbstract Precise tumor diagnosis and treatment remain complex challenges. While numerous fluorescent probes have been developed for tumor‐specific imaging and therapy, few exhibit effective function in vivo. Herein, a probe called TQ‐H2 is designed that can realize robust theranostic effects both in vitro and in vivo. In vitro, TQ‐H2 specifically targets the lysosome and reacts with hydroxyl radical (·OH) to generate TQ‐HA, which lights up the cells. TQ‐HA generates reactive oxygen species (ROS) under light irradiation, enabling the simultaneous induction and monitoring of apoptosis and ferroptosis in tumor cells. Remarkably, TQ‐HA also acts as a self‐amplifier, autocatalytically activating TQ‐H2 by generating ·OH under light exposure. This self‐amplification aligns with the tumor microenvironment, where TQ‐H2 undergoes chemical transformation, distinguishing tumors from healthy tissue via near‐infrared (NIR) fluorescence imaging. Furthermore, ROS generated by TQ‐HA effectively kills tumor cells and inhibits tumor growth without harming normal cells. This study offers a promising strategy for targeted tumor theranostics using self‐amplifying microenvironment‐responsive fluorescent probes.https://doi.org/10.1002/advs.202409506aggregation‐induced emissionautocatalytic reactioncancer theranosticshydroxyl radical probesspecific targeting |
| spellingShingle | Yunfei Zuo Pei Li Wen‐Jin Wang Changhuo Xu Shuting Xu Herman H. Y. Sung Jianwei Sun Guorui Jin Weiping Wang Ryan T. K. Kwok Jacky W. Y. Lam Ben Zhong Tang Tumor Site‐Specific In Vivo Theranostics Enabled by Microenvironment‐Dependent Chemical Transformation and Self‐Amplifying Effect Advanced Science aggregation‐induced emission autocatalytic reaction cancer theranostics hydroxyl radical probes specific targeting |
| title | Tumor Site‐Specific In Vivo Theranostics Enabled by Microenvironment‐Dependent Chemical Transformation and Self‐Amplifying Effect |
| title_full | Tumor Site‐Specific In Vivo Theranostics Enabled by Microenvironment‐Dependent Chemical Transformation and Self‐Amplifying Effect |
| title_fullStr | Tumor Site‐Specific In Vivo Theranostics Enabled by Microenvironment‐Dependent Chemical Transformation and Self‐Amplifying Effect |
| title_full_unstemmed | Tumor Site‐Specific In Vivo Theranostics Enabled by Microenvironment‐Dependent Chemical Transformation and Self‐Amplifying Effect |
| title_short | Tumor Site‐Specific In Vivo Theranostics Enabled by Microenvironment‐Dependent Chemical Transformation and Self‐Amplifying Effect |
| title_sort | tumor site specific in vivo theranostics enabled by microenvironment dependent chemical transformation and self amplifying effect |
| topic | aggregation‐induced emission autocatalytic reaction cancer theranostics hydroxyl radical probes specific targeting |
| url | https://doi.org/10.1002/advs.202409506 |
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