Exploration of the diagnostic and prognostic roles of decreased autoantibodies in lung cancer
IntroductionTumor-associated antigens (TAA) are proteins expressed during the growth and development of tumor cells, and TAA autoantibodies (TAAbs) can be detected in the serum of lung cancer patients, which can be utilized in the early screening of lung cancer. Almost all the TAAbs applied for diag...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538071/full |
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| author | Ying Ye Ying Ye Yi Huang Yi Huang Jianbo Pan Jianbo Pan |
| author_facet | Ying Ye Ying Ye Yi Huang Yi Huang Jianbo Pan Jianbo Pan |
| author_sort | Ying Ye |
| collection | DOAJ |
| description | IntroductionTumor-associated antigens (TAA) are proteins expressed during the growth and development of tumor cells, and TAA autoantibodies (TAAbs) can be detected in the serum of lung cancer patients, which can be utilized in the early screening of lung cancer. Almost all the TAAbs applied for diagnosis are those elevated, however, there are still large numbers of autoantibodies detected to decrease in tumor serums, and their functions were rarely known. Diagnosing malignant small lung nodules (≤3cm) in CT scans remains a challenge in clinical practice.MethodsIn this study, we applied the HuProt array and the bioinformatics analysis to assess the diagnostic values of the decreased autoantibodies in lung cancers.ResultsIn total, 15 types of decreased autoantibodies were identified, and 6 of them were constructed into a predictive model for early lung cancer, reaching a sensitivity of 76.19% and a specificity of 55.74%. We combined with 4 elevated TAAbs, the sensitivity and the specificity of the 10-marker model can attain 80.0% and 87.0%, respectively, which is higher than that of the commonly used 7-TAAbs model in diagnosis for early-stage lung cancer. Moreover, 5 of the decreased autoantibodies can also be applied for supervising bone metastasis in lung adenocarcinoma. A follow-up process for 13 patients diagnosed with early-stage lung cancer revealed that 10 of the 15 decreased autoantibodies would recover to a higher level after the tumor was resected. Bioinformatic analysis indicated that the 15 biomarkers were strongly correlated with the prognosis of lung cancer patients.ConclusionWe confirmed the importance of the decreased autoantibodies in lung cancer, providing new diagnostic and therapeutic strategies. |
| format | Article |
| id | doaj-art-bcf6de040cf94050b12d9f92d04465d9 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj-art-bcf6de040cf94050b12d9f92d04465d92025-01-30T06:22:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.15380711538071Exploration of the diagnostic and prognostic roles of decreased autoantibodies in lung cancerYing Ye0Ying Ye1Yi Huang2Yi Huang3Jianbo Pan4Jianbo Pan5Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, College of Pharmacy, Chongqing Medical University, Chongqing, ChinaDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, Fujian, ChinaBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, College of Pharmacy, Chongqing Medical University, Chongqing, ChinaPrecision Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaIntroductionTumor-associated antigens (TAA) are proteins expressed during the growth and development of tumor cells, and TAA autoantibodies (TAAbs) can be detected in the serum of lung cancer patients, which can be utilized in the early screening of lung cancer. Almost all the TAAbs applied for diagnosis are those elevated, however, there are still large numbers of autoantibodies detected to decrease in tumor serums, and their functions were rarely known. Diagnosing malignant small lung nodules (≤3cm) in CT scans remains a challenge in clinical practice.MethodsIn this study, we applied the HuProt array and the bioinformatics analysis to assess the diagnostic values of the decreased autoantibodies in lung cancers.ResultsIn total, 15 types of decreased autoantibodies were identified, and 6 of them were constructed into a predictive model for early lung cancer, reaching a sensitivity of 76.19% and a specificity of 55.74%. We combined with 4 elevated TAAbs, the sensitivity and the specificity of the 10-marker model can attain 80.0% and 87.0%, respectively, which is higher than that of the commonly used 7-TAAbs model in diagnosis for early-stage lung cancer. Moreover, 5 of the decreased autoantibodies can also be applied for supervising bone metastasis in lung adenocarcinoma. A follow-up process for 13 patients diagnosed with early-stage lung cancer revealed that 10 of the 15 decreased autoantibodies would recover to a higher level after the tumor was resected. Bioinformatic analysis indicated that the 15 biomarkers were strongly correlated with the prognosis of lung cancer patients.ConclusionWe confirmed the importance of the decreased autoantibodies in lung cancer, providing new diagnostic and therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538071/fullTAA autoantibodiesdecreased autoantibodiesearly-stage lung cancerdiagnostic modelsnovel tumor markers |
| spellingShingle | Ying Ye Ying Ye Yi Huang Yi Huang Jianbo Pan Jianbo Pan Exploration of the diagnostic and prognostic roles of decreased autoantibodies in lung cancer Frontiers in Immunology TAA autoantibodies decreased autoantibodies early-stage lung cancer diagnostic models novel tumor markers |
| title | Exploration of the diagnostic and prognostic roles of decreased autoantibodies in lung cancer |
| title_full | Exploration of the diagnostic and prognostic roles of decreased autoantibodies in lung cancer |
| title_fullStr | Exploration of the diagnostic and prognostic roles of decreased autoantibodies in lung cancer |
| title_full_unstemmed | Exploration of the diagnostic and prognostic roles of decreased autoantibodies in lung cancer |
| title_short | Exploration of the diagnostic and prognostic roles of decreased autoantibodies in lung cancer |
| title_sort | exploration of the diagnostic and prognostic roles of decreased autoantibodies in lung cancer |
| topic | TAA autoantibodies decreased autoantibodies early-stage lung cancer diagnostic models novel tumor markers |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538071/full |
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