Comparative Assessment of Subgingivally Delivered 2% Curcumin Gel as an Adjunct to Scaling and Root Planing in Smokers with Chronic Periodontitis: A Clinical Study
Background: Chronic periodontitis is a common inflammatory condition that is worsened in smokers owing to the harmful impact of smoking on periodontal tissues. Curcumin gel has shown promise as a local medication delivery method owing to its anti-inflammatory, antioxidant, and antibacterial effects....
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_255_25 |
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| author | Shruti Gupta S. G Jyothi Arif Siddiqui Anishka Dhanai Hemlata Yadav Utkarsh Singh |
| author_facet | Shruti Gupta S. G Jyothi Arif Siddiqui Anishka Dhanai Hemlata Yadav Utkarsh Singh |
| author_sort | Shruti Gupta |
| collection | DOAJ |
| description | Background:
Chronic periodontitis is a common inflammatory condition that is worsened in smokers owing to the harmful impact of smoking on periodontal tissues. Curcumin gel has shown promise as a local medication delivery method owing to its anti-inflammatory, antioxidant, and antibacterial effects.
Materials and Methods:
A randomized clinical study was performed on 40 smokers diagnosed with chronic periodontitis. Participants were categorized into two groups: Group A (n = 20) had scale and root planing (SRP) only, while Group B (n = 20) got SRP in conjunction with curcumin gel as a local medication delivery supplement. Clinical measures, including as probing pocket depth (PPD), clinical attachment level (CAL), and gingival index (GI), were evaluated at baseline, 4 weeks, and 8 weeks. Curcumin gel was administered in periodontal pockets with probing pocket depth (PPD) ≥5 mm in patients of Group B.
Outcomes:
At 8 weeks, Group B exhibited a significant decrease in PPD (mean reduction: 3.5 mm) compared to Group A (mean reduction: 2.0 mm). The improvement in clinical attachment level (CAL) was more pronounced in Group B (mean gain: 2.8 mm) compared to Group A (mean gain: 1.5 mm). Group B had a substantial drop in GI scores (mean reduction: 1.2) vs to Group A (mean reduction: 0.8). The supplementary use of curcumin gel led to statistically significant improvements in all clinical indicators (P < 0.05).
Conclusion:
Curcumin gel as a localized medication delivery adjunct significantly improves the clinical results of scaling and root planing in the treatment of chronic periodontitis in smokers. |
| format | Article |
| id | doaj-art-bcd79bb63488488aa2722eeeaeeff34a |
| institution | DOAJ |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-bcd79bb63488488aa2722eeeaeeff34a2025-08-20T02:42:28ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-06-0117Suppl 2S1683S168510.4103/jpbs.jpbs_255_25Comparative Assessment of Subgingivally Delivered 2% Curcumin Gel as an Adjunct to Scaling and Root Planing in Smokers with Chronic Periodontitis: A Clinical StudyShruti GuptaS. G JyothiArif SiddiquiAnishka DhanaiHemlata YadavUtkarsh SinghBackground: Chronic periodontitis is a common inflammatory condition that is worsened in smokers owing to the harmful impact of smoking on periodontal tissues. Curcumin gel has shown promise as a local medication delivery method owing to its anti-inflammatory, antioxidant, and antibacterial effects. Materials and Methods: A randomized clinical study was performed on 40 smokers diagnosed with chronic periodontitis. Participants were categorized into two groups: Group A (n = 20) had scale and root planing (SRP) only, while Group B (n = 20) got SRP in conjunction with curcumin gel as a local medication delivery supplement. Clinical measures, including as probing pocket depth (PPD), clinical attachment level (CAL), and gingival index (GI), were evaluated at baseline, 4 weeks, and 8 weeks. Curcumin gel was administered in periodontal pockets with probing pocket depth (PPD) ≥5 mm in patients of Group B. Outcomes: At 8 weeks, Group B exhibited a significant decrease in PPD (mean reduction: 3.5 mm) compared to Group A (mean reduction: 2.0 mm). The improvement in clinical attachment level (CAL) was more pronounced in Group B (mean gain: 2.8 mm) compared to Group A (mean gain: 1.5 mm). Group B had a substantial drop in GI scores (mean reduction: 1.2) vs to Group A (mean reduction: 0.8). The supplementary use of curcumin gel led to statistically significant improvements in all clinical indicators (P < 0.05). Conclusion: Curcumin gel as a localized medication delivery adjunct significantly improves the clinical results of scaling and root planing in the treatment of chronic periodontitis in smokers.https://journals.lww.com/10.4103/jpbs.jpbs_255_25chronic periodontitiscurcumin gellocal drug deliveryperiodontal therapyscaling and root planingsmokers |
| spellingShingle | Shruti Gupta S. G Jyothi Arif Siddiqui Anishka Dhanai Hemlata Yadav Utkarsh Singh Comparative Assessment of Subgingivally Delivered 2% Curcumin Gel as an Adjunct to Scaling and Root Planing in Smokers with Chronic Periodontitis: A Clinical Study Journal of Pharmacy and Bioallied Sciences chronic periodontitis curcumin gel local drug delivery periodontal therapy scaling and root planing smokers |
| title | Comparative Assessment of Subgingivally Delivered 2% Curcumin Gel as an Adjunct to Scaling and Root Planing in Smokers with Chronic Periodontitis: A Clinical Study |
| title_full | Comparative Assessment of Subgingivally Delivered 2% Curcumin Gel as an Adjunct to Scaling and Root Planing in Smokers with Chronic Periodontitis: A Clinical Study |
| title_fullStr | Comparative Assessment of Subgingivally Delivered 2% Curcumin Gel as an Adjunct to Scaling and Root Planing in Smokers with Chronic Periodontitis: A Clinical Study |
| title_full_unstemmed | Comparative Assessment of Subgingivally Delivered 2% Curcumin Gel as an Adjunct to Scaling and Root Planing in Smokers with Chronic Periodontitis: A Clinical Study |
| title_short | Comparative Assessment of Subgingivally Delivered 2% Curcumin Gel as an Adjunct to Scaling and Root Planing in Smokers with Chronic Periodontitis: A Clinical Study |
| title_sort | comparative assessment of subgingivally delivered 2 curcumin gel as an adjunct to scaling and root planing in smokers with chronic periodontitis a clinical study |
| topic | chronic periodontitis curcumin gel local drug delivery periodontal therapy scaling and root planing smokers |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_255_25 |
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