The role of NF-κB in diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM), a major risk factor contributing to diabetes-related morbidity and mortality, manifests as a pathophysiologic condition in humans independently of coronary artery disease or hypertension. Several transcription factors intricately participate in the initiation and progr...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | All Life |
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| Online Access: | http://dx.doi.org/10.1080/26895293.2024.2397402 |
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| _version_ | 1832593495657807872 |
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| author | Huang-Jun Liu Le-Kun Gui Han Wei Xing-Yu Zhou Zhen-Lan Liu Li-Jun Jin |
| author_facet | Huang-Jun Liu Le-Kun Gui Han Wei Xing-Yu Zhou Zhen-Lan Liu Li-Jun Jin |
| author_sort | Huang-Jun Liu |
| collection | DOAJ |
| description | Diabetic cardiomyopathy (DCM), a major risk factor contributing to diabetes-related morbidity and mortality, manifests as a pathophysiologic condition in humans independently of coronary artery disease or hypertension. Several transcription factors intricately participate in the initiation and progression of associated processes. Among these, nuclear factor kappa B (NF-κB), a pleiotropic transcription factor, assumes a crucial role in regulating oxidative stress, inflammatory response, endothelial dysfunction, myocardial fibrosis and hypertrophy, and cardiomyocyte apoptosis in DCM. However, the precise role of NF-κB in DCM remains a subject of ongoing investigation. This article provides a comprehensive review of NF-κB's involvement in several processes associated with DCM. |
| format | Article |
| id | doaj-art-bcca93e34e7e4b03947e0c072fec5f83 |
| institution | Kabale University |
| issn | 2689-5307 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | All Life |
| spelling | doaj-art-bcca93e34e7e4b03947e0c072fec5f832025-01-20T14:38:00ZengTaylor & Francis GroupAll Life2689-53072024-12-01170110.1080/26895293.2024.23974022397402The role of NF-κB in diabetic cardiomyopathyHuang-Jun Liu0Le-Kun Gui1Han Wei2Xing-Yu Zhou3Zhen-Lan Liu4Li-Jun Jin5The First Affiliated Hospital of Yangtze UniversityThe First Affiliated Hospital of Yangtze UniversityThe First Affiliated Hospital of Yangtze UniversityThe First Affiliated Hospital of Yangtze UniversityThe First Affiliated Hospital of Yangtze UniversityThe First Affiliated Hospital of Yangtze UniversityDiabetic cardiomyopathy (DCM), a major risk factor contributing to diabetes-related morbidity and mortality, manifests as a pathophysiologic condition in humans independently of coronary artery disease or hypertension. Several transcription factors intricately participate in the initiation and progression of associated processes. Among these, nuclear factor kappa B (NF-κB), a pleiotropic transcription factor, assumes a crucial role in regulating oxidative stress, inflammatory response, endothelial dysfunction, myocardial fibrosis and hypertrophy, and cardiomyocyte apoptosis in DCM. However, the precise role of NF-κB in DCM remains a subject of ongoing investigation. This article provides a comprehensive review of NF-κB's involvement in several processes associated with DCM.http://dx.doi.org/10.1080/26895293.2024.2397402diabetic cardiomyopathynf-κbheart failurediabetes mellitus |
| spellingShingle | Huang-Jun Liu Le-Kun Gui Han Wei Xing-Yu Zhou Zhen-Lan Liu Li-Jun Jin The role of NF-κB in diabetic cardiomyopathy All Life diabetic cardiomyopathy nf-κb heart failure diabetes mellitus |
| title | The role of NF-κB in diabetic cardiomyopathy |
| title_full | The role of NF-κB in diabetic cardiomyopathy |
| title_fullStr | The role of NF-κB in diabetic cardiomyopathy |
| title_full_unstemmed | The role of NF-κB in diabetic cardiomyopathy |
| title_short | The role of NF-κB in diabetic cardiomyopathy |
| title_sort | role of nf κb in diabetic cardiomyopathy |
| topic | diabetic cardiomyopathy nf-κb heart failure diabetes mellitus |
| url | http://dx.doi.org/10.1080/26895293.2024.2397402 |
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