Perianal Basal Cell Carcinoma Successfully Managed with Excisional Biopsy
Basal cell carcinoma (BCC) is the most common cutaneous malignancy in the United States and is often nonaggressive. Its location in the perianal region is very rare and it is estimated that only 0.08% of all BCCs occur in this region. Herein, we present a case of perianal basal cell carcinoma, nodul...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/6268354 |
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| author | Paola C. Aldana Harris G. Yfantis Preeti R. John |
| author_facet | Paola C. Aldana Harris G. Yfantis Preeti R. John |
| author_sort | Paola C. Aldana |
| collection | DOAJ |
| description | Basal cell carcinoma (BCC) is the most common cutaneous malignancy in the United States and is often nonaggressive. Its location in the perianal region is very rare and it is estimated that only 0.08% of all BCCs occur in this region. Herein, we present a case of perianal basal cell carcinoma, nodular type. The diagnosis was made using excisional biopsy of a skin lesion. Immunohistochemical staining confirmed the diagnosis: it showed diffuse and strong positivity for smooth muscle actin (SMA) and monoclonal antibody BER-Ep4 and was negative for carcinoembryonic antigen (CEA), pancytokeratin (AE1/AE3), and epithelial membrane antigen (EMA). The treatment of choice has traditionally been local excision to clear margins but the newest guidelines recommend Mohs Micrographic surgery (MMS) or standard 4mm surgical margins for this high-risk BCC. Our patient was successfully treated using excisional biopsy without recurrence. In select patients with lesions smaller than 1cm, excisional biopsy may be sufficient to treat the disease and may be better tolerated than MMS and wider surgical margins. Literature review suggests a predisposition for perianal BCC in individuals susceptible to cutaneous malignancies. Therefore, any history of cutaneous malignancy should further prompt clinicians to examine nonsun exposed areas on full body skin exams. |
| format | Article |
| id | doaj-art-bcb11bf744694b559182e458437beb25 |
| institution | Kabale University |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-bcb11bf744694b559182e458437beb252025-02-03T01:24:32ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712019-01-01201910.1155/2019/62683546268354Perianal Basal Cell Carcinoma Successfully Managed with Excisional BiopsyPaola C. Aldana0Harris G. Yfantis1Preeti R. John2University of Maryland School of Medicine, Baltimore, MD, USAUniversity of Maryland School of Medicine, Baltimore, MD, USAUniversity of Maryland School of Medicine, Baltimore, MD, USABasal cell carcinoma (BCC) is the most common cutaneous malignancy in the United States and is often nonaggressive. Its location in the perianal region is very rare and it is estimated that only 0.08% of all BCCs occur in this region. Herein, we present a case of perianal basal cell carcinoma, nodular type. The diagnosis was made using excisional biopsy of a skin lesion. Immunohistochemical staining confirmed the diagnosis: it showed diffuse and strong positivity for smooth muscle actin (SMA) and monoclonal antibody BER-Ep4 and was negative for carcinoembryonic antigen (CEA), pancytokeratin (AE1/AE3), and epithelial membrane antigen (EMA). The treatment of choice has traditionally been local excision to clear margins but the newest guidelines recommend Mohs Micrographic surgery (MMS) or standard 4mm surgical margins for this high-risk BCC. Our patient was successfully treated using excisional biopsy without recurrence. In select patients with lesions smaller than 1cm, excisional biopsy may be sufficient to treat the disease and may be better tolerated than MMS and wider surgical margins. Literature review suggests a predisposition for perianal BCC in individuals susceptible to cutaneous malignancies. Therefore, any history of cutaneous malignancy should further prompt clinicians to examine nonsun exposed areas on full body skin exams.http://dx.doi.org/10.1155/2019/6268354 |
| spellingShingle | Paola C. Aldana Harris G. Yfantis Preeti R. John Perianal Basal Cell Carcinoma Successfully Managed with Excisional Biopsy Case Reports in Dermatological Medicine |
| title | Perianal Basal Cell Carcinoma Successfully Managed with Excisional Biopsy |
| title_full | Perianal Basal Cell Carcinoma Successfully Managed with Excisional Biopsy |
| title_fullStr | Perianal Basal Cell Carcinoma Successfully Managed with Excisional Biopsy |
| title_full_unstemmed | Perianal Basal Cell Carcinoma Successfully Managed with Excisional Biopsy |
| title_short | Perianal Basal Cell Carcinoma Successfully Managed with Excisional Biopsy |
| title_sort | perianal basal cell carcinoma successfully managed with excisional biopsy |
| url | http://dx.doi.org/10.1155/2019/6268354 |
| work_keys_str_mv | AT paolacaldana perianalbasalcellcarcinomasuccessfullymanagedwithexcisionalbiopsy AT harrisgyfantis perianalbasalcellcarcinomasuccessfullymanagedwithexcisionalbiopsy AT preetirjohn perianalbasalcellcarcinomasuccessfullymanagedwithexcisionalbiopsy |