New perspectives on extracorporeal life support: expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation care
Extra Corporeal Life Support (ECLS) for pediatric oncology and stem cell transplant patients over the past two decades has made progress. Substantial improvements in ECLS, Continuous Renal Replacement Therapy (CRRT), and mechanical ventilation techniques, along with enhanced anticoagulation manageme...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1588403/full |
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| author | Caitlin Hurley Caitlin Hurley Matteo Di Nardo Matthew Rees Diego R. Hijano Diego R. Hijano Ahmed Said Ahmed Said Akshay Sharma Lama Elbahlawan Melissa R. Hines Melissa R. Hines Jennifer A. McArthur Hitesh Sandhu Hitesh Sandhu Hitesh Sandhu Saad Ghafoor Saad Ghafoor |
| author_facet | Caitlin Hurley Caitlin Hurley Matteo Di Nardo Matthew Rees Diego R. Hijano Diego R. Hijano Ahmed Said Ahmed Said Akshay Sharma Lama Elbahlawan Melissa R. Hines Melissa R. Hines Jennifer A. McArthur Hitesh Sandhu Hitesh Sandhu Hitesh Sandhu Saad Ghafoor Saad Ghafoor |
| author_sort | Caitlin Hurley |
| collection | DOAJ |
| description | Extra Corporeal Life Support (ECLS) for pediatric oncology and stem cell transplant patients over the past two decades has made progress. Substantial improvements in ECLS, Continuous Renal Replacement Therapy (CRRT), and mechanical ventilation techniques, along with enhanced anticoagulation management and infection control, have contributed to better patient outcomes. Additionally, advancements in HLA matching, donor selection, and the management of chemotherapy and transplant complications have further improved survival rates. The authors propose establishing an expert team and a standardized process to evaluate ECLS candidacy, addressing past controversies and optimizing outcomes for this vulnerable population. The criteria for candidacy have evolved significantly, necessitating expert evaluation. |
| format | Article |
| id | doaj-art-bca29a8c1ce343d2a73ce6bd5ed3effc |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-bca29a8c1ce343d2a73ce6bd5ed3effc2025-08-20T03:22:03ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-06-011510.3389/fonc.2025.15884031588403New perspectives on extracorporeal life support: expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation careCaitlin Hurley0Caitlin Hurley1Matteo Di Nardo2Matthew Rees3Diego R. Hijano4Diego R. Hijano5Ahmed Said6Ahmed Said7Akshay Sharma8Lama Elbahlawan9Melissa R. Hines10Melissa R. Hines11Jennifer A. McArthur12Hitesh Sandhu13Hitesh Sandhu14Hitesh Sandhu15Saad Ghafoor16Saad Ghafoor17Department of Pediatric Medicine, Division of Critical Care Medicine, St. Jude Children’s Research Hospital, Memphis, TN, United StatesDepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children’s Research Hospital, Memphis, TN, United StatesPediatric Intensive Care Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, ItalyDepartment of Oncology, St. Jude Children’s Research Hospital, Memphis, TN, United StatesDepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, United StatesDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, United StatesDivision of Pediatric Critical Care Medicine, St. Louis Children’s Hospital, Washington University School of Medicine, St. Louis, MO, United StatesInstitute for Informatics, Washington University School of Medicine, St. Louis, MO, United StatesDepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children’s Research Hospital, Memphis, TN, United StatesDepartment of Pediatric Medicine, Division of Critical Care Medicine, St. Jude Children’s Research Hospital, Memphis, TN, United StatesDepartment of Pediatric Medicine, Division of Critical Care Medicine, St. Jude Children’s Research Hospital, Memphis, TN, United StatesDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, United StatesDepartment of Pediatric Medicine, Division of Critical Care Medicine, St. Jude Children’s Research Hospital, Memphis, TN, United StatesDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, United StatesDepartment of Critical Care, Le Bonheur Children’s Hospital, Memphis, TN, United States0Extracorporeal Therapies Service Line, Le Bonheur Children’s Hospital, Memphis, TN, United StatesDepartment of Pediatric Medicine, Division of Critical Care Medicine, St. Jude Children’s Research Hospital, Memphis, TN, United StatesDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, United StatesExtra Corporeal Life Support (ECLS) for pediatric oncology and stem cell transplant patients over the past two decades has made progress. Substantial improvements in ECLS, Continuous Renal Replacement Therapy (CRRT), and mechanical ventilation techniques, along with enhanced anticoagulation management and infection control, have contributed to better patient outcomes. Additionally, advancements in HLA matching, donor selection, and the management of chemotherapy and transplant complications have further improved survival rates. The authors propose establishing an expert team and a standardized process to evaluate ECLS candidacy, addressing past controversies and optimizing outcomes for this vulnerable population. The criteria for candidacy have evolved significantly, necessitating expert evaluation.https://www.frontiersin.org/articles/10.3389/fonc.2025.1588403/fullextracorporeal life support (ECLS)extracorporeal membrane oxygenation (ECMO)pediatric oncologypediatric hematopoietic cell transplantpediatric critical care |
| spellingShingle | Caitlin Hurley Caitlin Hurley Matteo Di Nardo Matthew Rees Diego R. Hijano Diego R. Hijano Ahmed Said Ahmed Said Akshay Sharma Lama Elbahlawan Melissa R. Hines Melissa R. Hines Jennifer A. McArthur Hitesh Sandhu Hitesh Sandhu Hitesh Sandhu Saad Ghafoor Saad Ghafoor New perspectives on extracorporeal life support: expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation care Frontiers in Oncology extracorporeal life support (ECLS) extracorporeal membrane oxygenation (ECMO) pediatric oncology pediatric hematopoietic cell transplant pediatric critical care |
| title | New perspectives on extracorporeal life support: expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation care |
| title_full | New perspectives on extracorporeal life support: expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation care |
| title_fullStr | New perspectives on extracorporeal life support: expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation care |
| title_full_unstemmed | New perspectives on extracorporeal life support: expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation care |
| title_short | New perspectives on extracorporeal life support: expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation care |
| title_sort | new perspectives on extracorporeal life support expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation care |
| topic | extracorporeal life support (ECLS) extracorporeal membrane oxygenation (ECMO) pediatric oncology pediatric hematopoietic cell transplant pediatric critical care |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1588403/full |
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