Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis
Abstract Background To investigate the preventive efficacy of methylsulfonylmethane (MSM) on alveolar bone destruction in rats with periodontitis. Methods Twenty-four male Sprague-Dawley rats were randomly divided into three groups: control, experimental periodontitis (Ep), and Ep-MSM. Periodontitis...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Oral Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12903-025-05447-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594363950039040 |
|---|---|
| author | Melek Beder Hatice Yemenoglu Semih Alperen Bostan Oğuz Kose Sibel Mataracı Karakas Tolga Mercantepe Adnan Yılmaz Levent Tumkaya |
| author_facet | Melek Beder Hatice Yemenoglu Semih Alperen Bostan Oğuz Kose Sibel Mataracı Karakas Tolga Mercantepe Adnan Yılmaz Levent Tumkaya |
| author_sort | Melek Beder |
| collection | DOAJ |
| description | Abstract Background To investigate the preventive efficacy of methylsulfonylmethane (MSM) on alveolar bone destruction in rats with periodontitis. Methods Twenty-four male Sprague-Dawley rats were randomly divided into three groups: control, experimental periodontitis (Ep), and Ep-MSM. Periodontitis was induced by placing 4.0 silk sutures in the subparamarginal position on the necks of the mandibular first molars and applying the suture for 5 weeks. The Ep-MSM group was given 500 mg/body weight/day MSM intraperitoneally for 35 days. At the end of the study, bilateral mandibular samples were taken. Periodontal bone loss was measured through histologic sections. Histomorphometric and immunohistochemical (receptor activator of nuclear factor kappa B ligand (RANKL), osteoprotegerin (OPG)) evaluations were performed on right mandibular tissue samples, and biochemical (interleukin (IL)-1 beta (β)/IL-10, malondialdehyde (MDA), glutathione (GSH), oxidative stress index (OSI)) evaluations were performed on left mandibular tissue samples. Results No significant difference was found between the groups in IL-1β and IL-1β/IL-10 values (p > 0.05). A significant decrease in IL-10 levels was observed in the Ep-MSM and Ep groups compared with the control group (p < 0.05). MDA levels significantly increased in the Ep and Ep-MSM groups compared with the control group, and GSH levels significantly decreased in the Ep group compared with the other groups (p < 0.05). OSI values were significantly higher only in the Ep group (p < 0.05). RANKL levels showed a significant increase in the Ep group compared with the other groups. OPG levels were significantly increased only in the Ep-MSM group (p < 0.05). Conclusions The results of this study may suggest that MSM has preventive effects on alveolar bone loss and oxidative stress. |
| format | Article |
| id | doaj-art-bc9a370da5c0485fb417108d4c67176e |
| institution | Kabale University |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-bc9a370da5c0485fb417108d4c67176e2025-01-19T12:41:26ZengBMCBMC Oral Health1472-68312025-01-0125111310.1186/s12903-025-05447-yInvestigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitisMelek Beder0Hatice Yemenoglu1Semih Alperen Bostan2Oğuz Kose3Sibel Mataracı Karakas4Tolga Mercantepe5Adnan Yılmaz6Levent Tumkaya7Department of Periodontology, Faculty of Dentistry, Recep Tayyip Erdoğan UniversityDepartment of Periodontology, Faculty of Dentistry, Recep Tayyip Erdoğan UniversityDepartment of Periodontology, Faculty of Dentistry, Recep Tayyip Erdoğan UniversityDepartment of Periodontology, Faculty of Dentistry, Recep Tayyip Erdoğan UniversityDepartment of Biochemistry, Faculty of Medicine, Recep Tayyip Erdoğan UniversityDepartment of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdoğan UniversityDepartment of Biochemistry, Faculty of Medicine, Recep Tayyip Erdoğan UniversityDepartment of Histology and Embryology, Faculty of Medicine, Ondokuz Mayıs UniversityAbstract Background To investigate the preventive efficacy of methylsulfonylmethane (MSM) on alveolar bone destruction in rats with periodontitis. Methods Twenty-four male Sprague-Dawley rats were randomly divided into three groups: control, experimental periodontitis (Ep), and Ep-MSM. Periodontitis was induced by placing 4.0 silk sutures in the subparamarginal position on the necks of the mandibular first molars and applying the suture for 5 weeks. The Ep-MSM group was given 500 mg/body weight/day MSM intraperitoneally for 35 days. At the end of the study, bilateral mandibular samples were taken. Periodontal bone loss was measured through histologic sections. Histomorphometric and immunohistochemical (receptor activator of nuclear factor kappa B ligand (RANKL), osteoprotegerin (OPG)) evaluations were performed on right mandibular tissue samples, and biochemical (interleukin (IL)-1 beta (β)/IL-10, malondialdehyde (MDA), glutathione (GSH), oxidative stress index (OSI)) evaluations were performed on left mandibular tissue samples. Results No significant difference was found between the groups in IL-1β and IL-1β/IL-10 values (p > 0.05). A significant decrease in IL-10 levels was observed in the Ep-MSM and Ep groups compared with the control group (p < 0.05). MDA levels significantly increased in the Ep and Ep-MSM groups compared with the control group, and GSH levels significantly decreased in the Ep group compared with the other groups (p < 0.05). OSI values were significantly higher only in the Ep group (p < 0.05). RANKL levels showed a significant increase in the Ep group compared with the other groups. OPG levels were significantly increased only in the Ep-MSM group (p < 0.05). Conclusions The results of this study may suggest that MSM has preventive effects on alveolar bone loss and oxidative stress.https://doi.org/10.1186/s12903-025-05447-yAlveolar bone lossMethylsulfonylmethaneOxidative stressPeriodontitis |
| spellingShingle | Melek Beder Hatice Yemenoglu Semih Alperen Bostan Oğuz Kose Sibel Mataracı Karakas Tolga Mercantepe Adnan Yılmaz Levent Tumkaya Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis BMC Oral Health Alveolar bone loss Methylsulfonylmethane Oxidative stress Periodontitis |
| title | Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis |
| title_full | Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis |
| title_fullStr | Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis |
| title_full_unstemmed | Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis |
| title_short | Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis |
| title_sort | investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis |
| topic | Alveolar bone loss Methylsulfonylmethane Oxidative stress Periodontitis |
| url | https://doi.org/10.1186/s12903-025-05447-y |
| work_keys_str_mv | AT melekbeder investigationofthepreventiveeffectofmethylsulfonylmethaneonalveolarbonelossandoxidativestressinaratmodelofperiodontitis AT haticeyemenoglu investigationofthepreventiveeffectofmethylsulfonylmethaneonalveolarbonelossandoxidativestressinaratmodelofperiodontitis AT semihalperenbostan investigationofthepreventiveeffectofmethylsulfonylmethaneonalveolarbonelossandoxidativestressinaratmodelofperiodontitis AT oguzkose investigationofthepreventiveeffectofmethylsulfonylmethaneonalveolarbonelossandoxidativestressinaratmodelofperiodontitis AT sibelmataracıkarakas investigationofthepreventiveeffectofmethylsulfonylmethaneonalveolarbonelossandoxidativestressinaratmodelofperiodontitis AT tolgamercantepe investigationofthepreventiveeffectofmethylsulfonylmethaneonalveolarbonelossandoxidativestressinaratmodelofperiodontitis AT adnanyılmaz investigationofthepreventiveeffectofmethylsulfonylmethaneonalveolarbonelossandoxidativestressinaratmodelofperiodontitis AT leventtumkaya investigationofthepreventiveeffectofmethylsulfonylmethaneonalveolarbonelossandoxidativestressinaratmodelofperiodontitis |