Robust Optimization of Alginate-Carbopol 940 Bead Formulations
Formulation process is a very complex activity which sometimes implicates taking decisions about parameters or variables to obtain the best results in a high variability or uncertainty context. Therefore, robust optimization tools can be very useful for obtaining high quality formulations. This pape...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/605610 |
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| author | J. M. López-Cacho Pedro L. González-R B. Talero A. M. Rabasco M. L. González-Rodríguez |
| author_facet | J. M. López-Cacho Pedro L. González-R B. Talero A. M. Rabasco M. L. González-Rodríguez |
| author_sort | J. M. López-Cacho |
| collection | DOAJ |
| description | Formulation process is a very complex activity which sometimes implicates taking decisions about parameters or variables to obtain the best results in a high variability or uncertainty context. Therefore, robust optimization tools can be very useful for obtaining high quality formulations. This paper proposes the optimization of different responses through the robust Taguchi method. Each response was evaluated like a noise variable, allowing the application of Taguchi techniques to obtain a response under the point of view of the signal to noise ratio. A L18 Taguchi orthogonal array design was employed to investigate the effect of eight independent variables involved in the formulation of alginate-Carbopol beads. Responses evaluated were related to drug release profile from beads (t50% and AUC), swelling performance, encapsulation efficiency, shape and size parameters. Confirmation tests to verify the prediction model were carried out and the obtained results were very similar to those predicted in every profile. Results reveal that the robust optimization is a very useful approach that allows greater precision and accuracy to the desired value. |
| format | Article |
| id | doaj-art-bc86c27e8b854d3386112f4a35e1c73b |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-bc86c27e8b854d3386112f4a35e1c73b2025-02-03T07:24:05ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/605610605610Robust Optimization of Alginate-Carbopol 940 Bead FormulationsJ. M. López-Cacho0Pedro L. González-R1B. Talero2A. M. Rabasco3M. L. González-Rodríguez4Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, C/ Professor García González 2, 41012 Seville, SpainDepartment of Industrial Management, School of Engineering, University of Seville, C/ Camino de los Descubrimientos s/n, 41092 Seville, SpainDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, C/ Professor García González 2, 41012 Seville, SpainDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, C/ Professor García González 2, 41012 Seville, SpainDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, C/ Professor García González 2, 41012 Seville, SpainFormulation process is a very complex activity which sometimes implicates taking decisions about parameters or variables to obtain the best results in a high variability or uncertainty context. Therefore, robust optimization tools can be very useful for obtaining high quality formulations. This paper proposes the optimization of different responses through the robust Taguchi method. Each response was evaluated like a noise variable, allowing the application of Taguchi techniques to obtain a response under the point of view of the signal to noise ratio. A L18 Taguchi orthogonal array design was employed to investigate the effect of eight independent variables involved in the formulation of alginate-Carbopol beads. Responses evaluated were related to drug release profile from beads (t50% and AUC), swelling performance, encapsulation efficiency, shape and size parameters. Confirmation tests to verify the prediction model were carried out and the obtained results were very similar to those predicted in every profile. Results reveal that the robust optimization is a very useful approach that allows greater precision and accuracy to the desired value.http://dx.doi.org/10.1100/2012/605610 |
| spellingShingle | J. M. López-Cacho Pedro L. González-R B. Talero A. M. Rabasco M. L. González-Rodríguez Robust Optimization of Alginate-Carbopol 940 Bead Formulations The Scientific World Journal |
| title | Robust Optimization of Alginate-Carbopol 940 Bead Formulations |
| title_full | Robust Optimization of Alginate-Carbopol 940 Bead Formulations |
| title_fullStr | Robust Optimization of Alginate-Carbopol 940 Bead Formulations |
| title_full_unstemmed | Robust Optimization of Alginate-Carbopol 940 Bead Formulations |
| title_short | Robust Optimization of Alginate-Carbopol 940 Bead Formulations |
| title_sort | robust optimization of alginate carbopol 940 bead formulations |
| url | http://dx.doi.org/10.1100/2012/605610 |
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