Anterior Chamber Flare as an Objective and Quantitative Noninvasive Method for Oculopathy in Transthyretin V30M Amyloidosis Patients
Purpose. Assess the aqueous humor flare in transthyretin V30M amyloidosis patients (ATTRV30M). Materials and Methods. This is a retrospective, cross-sectional, noninterventional comparative study including 28 ATTRV30M patients with a unilateral scalloped iris. For comparative analysis, the fellow ey...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2018/3727543 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560412554428416 |
|---|---|
| author | João Beirão Vasco Miranda Beatriz Pinheiro-Torres João Coelho Maria-João Menéres Pedro Menéres |
| author_facet | João Beirão Vasco Miranda Beatriz Pinheiro-Torres João Coelho Maria-João Menéres Pedro Menéres |
| author_sort | João Beirão |
| collection | DOAJ |
| description | Purpose. Assess the aqueous humor flare in transthyretin V30M amyloidosis patients (ATTRV30M). Materials and Methods. This is a retrospective, cross-sectional, noninterventional comparative study including 28 ATTRV30M patients with a unilateral scalloped iris. For comparative analysis, the fellow eye, the nonscalloped iris eye, from each patient was used as control. All patients underwent aqueous humor flare meter and intraocular pressure (IOP) measurements. Results. Mean aqueous humor flare was significantly higher in the eyes with the scalloped iris than the control group with the nonscalloped iris (14.1 ± 2.2 versus 6.5 ± 0.9 pc/ms, respectively). No significant differences in IOP were found in the scalloped iris eyes than those in the nonscalloped iris control group (17.1 ± 0.8 versus 16.8 ± 0.7 mmHg, respectively). No significant correlation was not found between the flare and the IOP value within groups. Conclusions. In this study, aqueous humor flare values in the scalloped iris eyes may be a valid marker for controlling the stage of the oculopathy in ATTRV30M patients. |
| format | Article |
| id | doaj-art-bc571af66c7c411a9c2dfa1b39546aa8 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-bc571af66c7c411a9c2dfa1b39546aa82025-02-03T01:27:45ZengWileyJournal of Ophthalmology2090-004X2090-00582018-01-01201810.1155/2018/37275433727543Anterior Chamber Flare as an Objective and Quantitative Noninvasive Method for Oculopathy in Transthyretin V30M Amyloidosis PatientsJoão Beirão0Vasco Miranda1Beatriz Pinheiro-Torres2João Coelho3Maria-João Menéres4Pedro Menéres5Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, PortugalCentro Hospitalar Porto, Porto, PortugalAlimera Sciences, Alpharetta, USACentro Hospitalar Porto, Porto, PortugalCentro Hospitalar Porto, Porto, PortugalInstituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, PortugalPurpose. Assess the aqueous humor flare in transthyretin V30M amyloidosis patients (ATTRV30M). Materials and Methods. This is a retrospective, cross-sectional, noninterventional comparative study including 28 ATTRV30M patients with a unilateral scalloped iris. For comparative analysis, the fellow eye, the nonscalloped iris eye, from each patient was used as control. All patients underwent aqueous humor flare meter and intraocular pressure (IOP) measurements. Results. Mean aqueous humor flare was significantly higher in the eyes with the scalloped iris than the control group with the nonscalloped iris (14.1 ± 2.2 versus 6.5 ± 0.9 pc/ms, respectively). No significant differences in IOP were found in the scalloped iris eyes than those in the nonscalloped iris control group (17.1 ± 0.8 versus 16.8 ± 0.7 mmHg, respectively). No significant correlation was not found between the flare and the IOP value within groups. Conclusions. In this study, aqueous humor flare values in the scalloped iris eyes may be a valid marker for controlling the stage of the oculopathy in ATTRV30M patients.http://dx.doi.org/10.1155/2018/3727543 |
| spellingShingle | João Beirão Vasco Miranda Beatriz Pinheiro-Torres João Coelho Maria-João Menéres Pedro Menéres Anterior Chamber Flare as an Objective and Quantitative Noninvasive Method for Oculopathy in Transthyretin V30M Amyloidosis Patients Journal of Ophthalmology |
| title | Anterior Chamber Flare as an Objective and Quantitative Noninvasive Method for Oculopathy in Transthyretin V30M Amyloidosis Patients |
| title_full | Anterior Chamber Flare as an Objective and Quantitative Noninvasive Method for Oculopathy in Transthyretin V30M Amyloidosis Patients |
| title_fullStr | Anterior Chamber Flare as an Objective and Quantitative Noninvasive Method for Oculopathy in Transthyretin V30M Amyloidosis Patients |
| title_full_unstemmed | Anterior Chamber Flare as an Objective and Quantitative Noninvasive Method for Oculopathy in Transthyretin V30M Amyloidosis Patients |
| title_short | Anterior Chamber Flare as an Objective and Quantitative Noninvasive Method for Oculopathy in Transthyretin V30M Amyloidosis Patients |
| title_sort | anterior chamber flare as an objective and quantitative noninvasive method for oculopathy in transthyretin v30m amyloidosis patients |
| url | http://dx.doi.org/10.1155/2018/3727543 |
| work_keys_str_mv | AT joaobeirao anteriorchamberflareasanobjectiveandquantitativenoninvasivemethodforoculopathyintransthyretinv30mamyloidosispatients AT vascomiranda anteriorchamberflareasanobjectiveandquantitativenoninvasivemethodforoculopathyintransthyretinv30mamyloidosispatients AT beatrizpinheirotorres anteriorchamberflareasanobjectiveandquantitativenoninvasivemethodforoculopathyintransthyretinv30mamyloidosispatients AT joaocoelho anteriorchamberflareasanobjectiveandquantitativenoninvasivemethodforoculopathyintransthyretinv30mamyloidosispatients AT mariajoaomeneres anteriorchamberflareasanobjectiveandquantitativenoninvasivemethodforoculopathyintransthyretinv30mamyloidosispatients AT pedromeneres anteriorchamberflareasanobjectiveandquantitativenoninvasivemethodforoculopathyintransthyretinv30mamyloidosispatients |