Molecular characterization of HIV-1 near-full-length proviral quasispecies in monocytes from patients across different virological responses

Molecular characterization of HIV-1 near-full-length proviral quasispecies in monocytes from patients across different virological responses

IntroductionLow-level viremia (LLV) in HIV infection, defined as detectable but low plasma viral load, is associated with an increased risk of virological failure (VF); however, the mechanisms underlying LLV remain unclear. Monocytes, as potential viral reservoirs, can migrate into tissues and diffe...

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Main Authors: Jian Li, Chuyu Zhang, Zhenyi Zou, Yawen Liang, Peng Ma, Yun Lan, Quanmin Li, Qian Kong, Ruiying He, Linghua Li, Weilie Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Microbiology
Subjects:
HIV-1
quasispecies
monocytes
low-level viremia
antiretroviral therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1647986/full
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