Altered leptin signaling and attenuated cardiac vagal activity in rats with type 2 diabetes

Altered leptin signaling and attenuated cardiac vagal activity in rats with type 2 diabetes

IntroductionThe leading cause of death in type 2 diabetes mellitus (T2DM) patients is cardiovascular-related events, including myocardial infraction-induced ventricular arrhythmia. Previous studies have shown that T2DM-induced functional remodeling of cardiac vagal postganglionic (CVP) neurons contr...

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Bibliographic Details
Main Authors: Anthony J. Evans, Huiyin Tu, Yu Li, Boris Shabaltiy, Lauren Whitney, Kassidy Carpenter, Yu-long Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Physiology
Subjects:
cardiac parasympathetic activity
intracardiac ganglia
leptin resistance
type 2 diabetes
uncoupling protein 2
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1547901/full
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