Synthesis and Antibacterial Activity of Chalcones and Pyrimidine-2-ones
Some new chalcones have been prepared by Claisen-schmidt condensation of ketone and different aromatic aldehydes. These chalcones on condensation with urea in presence of acid gave Pyrimidine-2-ones. The synthesized compounds have been characterized by elemental analysis, IR and 1H NMR spectral data...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2005/134830 |
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| author | A. K. Parekh K. K. Desai |
| author_facet | A. K. Parekh K. K. Desai |
| author_sort | A. K. Parekh |
| collection | DOAJ |
| description | Some new chalcones have been prepared by Claisen-schmidt condensation of ketone and different aromatic aldehydes. These chalcones on condensation with urea in presence of acid gave Pyrimidine-2-ones. The synthesized compounds have been characterized by elemental analysis, IR and 1H NMR spectral data. They have been screened for their antibacterial activity against Gram positive bacteria B. subtillis & S. aureus and Gram negative bacteria E. coli & S. typhi. |
| format | Article |
| id | doaj-art-bc163cafd15d401282000ed219622787 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-bc163cafd15d401282000ed2196227872025-02-03T01:23:32ZengWileyE-Journal of Chemistry0973-49452090-98102005-01-012210911210.1155/2005/134830Synthesis and Antibacterial Activity of Chalcones and Pyrimidine-2-onesA. K. Parekh0K. K. Desai1Department of chemistry, Veer Narmad South Gujarat University, Surat-395007, IndiaDepartment of chemistry, Veer Narmad South Gujarat University, Surat-395007, IndiaSome new chalcones have been prepared by Claisen-schmidt condensation of ketone and different aromatic aldehydes. These chalcones on condensation with urea in presence of acid gave Pyrimidine-2-ones. The synthesized compounds have been characterized by elemental analysis, IR and 1H NMR spectral data. They have been screened for their antibacterial activity against Gram positive bacteria B. subtillis & S. aureus and Gram negative bacteria E. coli & S. typhi.http://dx.doi.org/10.1155/2005/134830 |
| spellingShingle | A. K. Parekh K. K. Desai Synthesis and Antibacterial Activity of Chalcones and Pyrimidine-2-ones E-Journal of Chemistry |
| title | Synthesis and Antibacterial Activity of Chalcones and Pyrimidine-2-ones |
| title_full | Synthesis and Antibacterial Activity of Chalcones and Pyrimidine-2-ones |
| title_fullStr | Synthesis and Antibacterial Activity of Chalcones and Pyrimidine-2-ones |
| title_full_unstemmed | Synthesis and Antibacterial Activity of Chalcones and Pyrimidine-2-ones |
| title_short | Synthesis and Antibacterial Activity of Chalcones and Pyrimidine-2-ones |
| title_sort | synthesis and antibacterial activity of chalcones and pyrimidine 2 ones |
| url | http://dx.doi.org/10.1155/2005/134830 |
| work_keys_str_mv | AT akparekh synthesisandantibacterialactivityofchalconesandpyrimidine2ones AT kkdesai synthesisandantibacterialactivityofchalconesandpyrimidine2ones |