Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude Conditions
This study tested the impact of moxidectin at peripartum on nematode fecal egg count (FEC) and clinical parameters on ewes in the high altitude tropical Andes of Colombia. FEC and clinical evaluations were performed on 9 occasions in 43 naturally infected ewes before and during gestation and after l...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2015/932080 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553495235919872 |
|---|---|
| author | J. J. Vargas-Duarte H. Lozano-Márquez H. A. Grajales-Lombana C. Manrique-Perdomo D. A. Martínez-Bello C. Saegerman M. Raes N. Kirschvink |
| author_facet | J. J. Vargas-Duarte H. Lozano-Márquez H. A. Grajales-Lombana C. Manrique-Perdomo D. A. Martínez-Bello C. Saegerman M. Raes N. Kirschvink |
| author_sort | J. J. Vargas-Duarte |
| collection | DOAJ |
| description | This study tested the impact of moxidectin at peripartum on nematode fecal egg count (FEC) and clinical parameters on ewes in the high altitude tropical Andes of Colombia. FEC and clinical evaluations were performed on 9 occasions in 43 naturally infected ewes before and during gestation and after lambing. Moxidectin (Mox, 200 µg kg−1) was applied at late pregnancy (T1, n=15) or 48 hours after parturition (T2, n=14). 14 untreated ewes served as controls (C). Suckling lambs (n=58) remained untreated and underwent four clinical and parasitological evaluations until 8 weeks after birth. Mox efficacy equaled 99.3% (T1) and 96.9% (T2). Highest mean FEC value reflecting periparturient nematode egg rise (PPER) was recorded in C ewes at 4–6 weeks after lambing. Significant FEC reductions were found in T1 (94.8%) and T2 (96.7%) ewes (p<0.05). All lambs showed a significant and ewes-group independent increase in FEC before weaning (p<0.05). Clinical parameters (anemia and diarrhea) showed time- and treatment-related differences (p<0.05). Monitoring of FEC and clinical parameters linked to gastrointestinal parasite infections allowed demonstrating that postpartum or preweaning are two critical periods to nematode infection for sheep raised under tropical Andes high altitude conditions. Use of Mox as anthelmintic treatment prevented PPER. |
| format | Article |
| id | doaj-art-bc041bdbedb64eeca52c233de0134cdc |
| institution | Kabale University |
| issn | 2090-8113 2042-0048 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-bc041bdbedb64eeca52c233de0134cdc2025-02-03T05:53:55ZengWileyVeterinary Medicine International2090-81132042-00482015-01-01201510.1155/2015/932080932080Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude ConditionsJ. J. Vargas-Duarte0H. Lozano-Márquez1H. A. Grajales-Lombana2C. Manrique-Perdomo3D. A. Martínez-Bello4C. Saegerman5M. Raes6N. Kirschvink7Genetic Institute, National University of Colombia, Carrera 30 No. 45-03, Edificio 426, Bogotá D.C., ColombiaUnit of Integrated Veterinary Research, Department of Veterinary Medicine, University of Namur, rue de Bruxelles 61, 5000 Namur, BelgiumFaculty of Veterinary Medicine and Animal Science, National University of Colombia, Carrera 30 No. 45-03, Edificio 481, Bogotá D.C., ColombiaFaculty of Veterinary Medicine and Animal Science, National University of Colombia, Carrera 30 No. 45-03, Edificio 481, Bogotá D.C., ColombiaFaculty of Veterinary Medicine, Cooperative University of Colombia, Calle 30 No. 33-51, Bucaramanga, ColombiaResearch Unit of Epidemiology and Risk Analysis Applied to Veterinary Sciences (UREAR), Fundamental and Applied Research for Animal and Health (FARAH), University of Liège, boulevard de Colonster 20, 4000 Liège, BelgiumUnit of Integrated Veterinary Research, Department of Veterinary Medicine, University of Namur, rue de Bruxelles 61, 5000 Namur, BelgiumUnit of Integrated Veterinary Research, Department of Veterinary Medicine, University of Namur, rue de Bruxelles 61, 5000 Namur, BelgiumThis study tested the impact of moxidectin at peripartum on nematode fecal egg count (FEC) and clinical parameters on ewes in the high altitude tropical Andes of Colombia. FEC and clinical evaluations were performed on 9 occasions in 43 naturally infected ewes before and during gestation and after lambing. Moxidectin (Mox, 200 µg kg−1) was applied at late pregnancy (T1, n=15) or 48 hours after parturition (T2, n=14). 14 untreated ewes served as controls (C). Suckling lambs (n=58) remained untreated and underwent four clinical and parasitological evaluations until 8 weeks after birth. Mox efficacy equaled 99.3% (T1) and 96.9% (T2). Highest mean FEC value reflecting periparturient nematode egg rise (PPER) was recorded in C ewes at 4–6 weeks after lambing. Significant FEC reductions were found in T1 (94.8%) and T2 (96.7%) ewes (p<0.05). All lambs showed a significant and ewes-group independent increase in FEC before weaning (p<0.05). Clinical parameters (anemia and diarrhea) showed time- and treatment-related differences (p<0.05). Monitoring of FEC and clinical parameters linked to gastrointestinal parasite infections allowed demonstrating that postpartum or preweaning are two critical periods to nematode infection for sheep raised under tropical Andes high altitude conditions. Use of Mox as anthelmintic treatment prevented PPER.http://dx.doi.org/10.1155/2015/932080 |
| spellingShingle | J. J. Vargas-Duarte H. Lozano-Márquez H. A. Grajales-Lombana C. Manrique-Perdomo D. A. Martínez-Bello C. Saegerman M. Raes N. Kirschvink Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude Conditions Veterinary Medicine International |
| title | Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude Conditions |
| title_full | Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude Conditions |
| title_fullStr | Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude Conditions |
| title_full_unstemmed | Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude Conditions |
| title_short | Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude Conditions |
| title_sort | effect of moxidectin treatment at peripartum on gastrointestinal parasite infections in ewes raised under tropical andes high altitude conditions |
| url | http://dx.doi.org/10.1155/2015/932080 |
| work_keys_str_mv | AT jjvargasduarte effectofmoxidectintreatmentatperipartumongastrointestinalparasiteinfectionsinewesraisedundertropicalandeshighaltitudeconditions AT hlozanomarquez effectofmoxidectintreatmentatperipartumongastrointestinalparasiteinfectionsinewesraisedundertropicalandeshighaltitudeconditions AT hagrajaleslombana effectofmoxidectintreatmentatperipartumongastrointestinalparasiteinfectionsinewesraisedundertropicalandeshighaltitudeconditions AT cmanriqueperdomo effectofmoxidectintreatmentatperipartumongastrointestinalparasiteinfectionsinewesraisedundertropicalandeshighaltitudeconditions AT damartinezbello effectofmoxidectintreatmentatperipartumongastrointestinalparasiteinfectionsinewesraisedundertropicalandeshighaltitudeconditions AT csaegerman effectofmoxidectintreatmentatperipartumongastrointestinalparasiteinfectionsinewesraisedundertropicalandeshighaltitudeconditions AT mraes effectofmoxidectintreatmentatperipartumongastrointestinalparasiteinfectionsinewesraisedundertropicalandeshighaltitudeconditions AT nkirschvink effectofmoxidectintreatmentatperipartumongastrointestinalparasiteinfectionsinewesraisedundertropicalandeshighaltitudeconditions |