Synchronous Collagenous Sprue and Enteropathy-Type T Cell Lymphoma: Variants of the Same Disease
A 64-year-old man with treated hypothyroidism had 10 months of diarrhea, abdominal pain, anorexia and recent involuntary 13.6 kg weight loss. He presented to hospital with an acute abdomen that had a radiological correlate of free air under the diaphragm. He was diagnosed with a perforated mid-jejun...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2004/583484 |
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| author | SAC Medlicott PL Beck S Loken T Crabtree |
| author_facet | SAC Medlicott PL Beck S Loken T Crabtree |
| author_sort | SAC Medlicott |
| collection | DOAJ |
| description | A 64-year-old man with treated hypothyroidism had 10 months of diarrhea, abdominal pain, anorexia and recent involuntary 13.6 kg weight loss. He presented to hospital with an acute abdomen that had a radiological correlate of free air under the diaphragm. He was diagnosed with a perforated mid-jejunum due to an ulcerated enteropathy-type T cell lymphoma (ETL), complicating collagenous sprue and cryptic celiac disease. Polymerase chain reaction verified monoclonal g- and b-T cell receptor gene rearrangements in the neoplasm. He had a complete resolution of symptoms when treated with a gluten-free diet in the postoperative period. This is apparently the first report describing collagenous sprue and ETL as synchronous lesions. Because atypical CD8+ lymphocytes are in both the collagenous sprue epithelium and ETL, the implication is that collagenous sprue is a noninvasive component of the ETL. |
| format | Article |
| id | doaj-art-bc016884ca8e49579aa0f4a302e89ed0 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-bc016884ca8e49579aa0f4a302e89ed02025-02-03T01:30:09ZengWileyCanadian Journal of Gastroenterology0835-79002004-01-0118532933210.1155/2004/583484Synchronous Collagenous Sprue and Enteropathy-Type T Cell Lymphoma: Variants of the Same DiseaseSAC Medlicott0PL Beck1S Loken2T Crabtree3Calgary Laboratory Services, Peter Lougheed and Foothills Medical Centre, Calgary, Alberta, CanadaDepartment of Gastronterology, Peter Lougheed and Foothills Medical Centre, Calgary, Alberta, CanadaCalgary Laboratory Services, Peter Lougheed and Foothills Medical Centre, Calgary, Alberta, CanadaCalgary Laboratory Services, Peter Lougheed and Foothills Medical Centre, Calgary, Alberta, CanadaA 64-year-old man with treated hypothyroidism had 10 months of diarrhea, abdominal pain, anorexia and recent involuntary 13.6 kg weight loss. He presented to hospital with an acute abdomen that had a radiological correlate of free air under the diaphragm. He was diagnosed with a perforated mid-jejunum due to an ulcerated enteropathy-type T cell lymphoma (ETL), complicating collagenous sprue and cryptic celiac disease. Polymerase chain reaction verified monoclonal g- and b-T cell receptor gene rearrangements in the neoplasm. He had a complete resolution of symptoms when treated with a gluten-free diet in the postoperative period. This is apparently the first report describing collagenous sprue and ETL as synchronous lesions. Because atypical CD8+ lymphocytes are in both the collagenous sprue epithelium and ETL, the implication is that collagenous sprue is a noninvasive component of the ETL.http://dx.doi.org/10.1155/2004/583484 |
| spellingShingle | SAC Medlicott PL Beck S Loken T Crabtree Synchronous Collagenous Sprue and Enteropathy-Type T Cell Lymphoma: Variants of the Same Disease Canadian Journal of Gastroenterology |
| title | Synchronous Collagenous Sprue and Enteropathy-Type T Cell Lymphoma: Variants of the Same Disease |
| title_full | Synchronous Collagenous Sprue and Enteropathy-Type T Cell Lymphoma: Variants of the Same Disease |
| title_fullStr | Synchronous Collagenous Sprue and Enteropathy-Type T Cell Lymphoma: Variants of the Same Disease |
| title_full_unstemmed | Synchronous Collagenous Sprue and Enteropathy-Type T Cell Lymphoma: Variants of the Same Disease |
| title_short | Synchronous Collagenous Sprue and Enteropathy-Type T Cell Lymphoma: Variants of the Same Disease |
| title_sort | synchronous collagenous sprue and enteropathy type t cell lymphoma variants of the same disease |
| url | http://dx.doi.org/10.1155/2004/583484 |
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