The genetics and hormonal basis of human gender identity

ABSTRACT Gender identity refers to one's psychological sense of their own gender. Establishing gender identity is a complex phenomenon, and the diversity of gender expression challenges simplistic or unified explanations. For this reason, the extent to which it is determined by nature (biologic...

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Main Authors: Rafael Loch Batista, Luciana Mattos Barros Oliveira
Format: Article
Language:English
Published: Brazilian Society of Endocrinology and Metabolism 2025-01-01
Series:Archives of Endocrinology and Metabolism
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000704&lng=en&tlng=en
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author Rafael Loch Batista
Luciana Mattos Barros Oliveira
author_facet Rafael Loch Batista
Luciana Mattos Barros Oliveira
author_sort Rafael Loch Batista
collection DOAJ
description ABSTRACT Gender identity refers to one's psychological sense of their own gender. Establishing gender identity is a complex phenomenon, and the diversity of gender expression challenges simplistic or unified explanations. For this reason, the extent to which it is determined by nature (biological) or nurture (social) is still debatable. The biological basis of gender identity cannot be modeled in animals and is best studied in people who identify with a gender that is different from the sex of their genitals such as transgender people and people with disorders/differences of sex development. Numerous research studies have delved into unraveling the intricate interplay of hormonal, neuroanatomic/neurofunctional, and genetic factors in the complex development of core gender identity. In this review, we explore and consolidate existing research that provides insights into the biological foundations of gender identity, enhancing our understanding of this intriguing human psychological trait.
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spelling doaj-art-bbf59dfa4af346d781cbf0462c8097b42025-01-21T07:45:19ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922025-01-0168spe110.20945/2359-4292-2024-0232The genetics and hormonal basis of human gender identityRafael Loch Batistahttps://orcid.org/0000-0002-5461-0301Luciana Mattos Barros Oliveirahttps://orcid.org/0000-0001-5346-8449ABSTRACT Gender identity refers to one's psychological sense of their own gender. Establishing gender identity is a complex phenomenon, and the diversity of gender expression challenges simplistic or unified explanations. For this reason, the extent to which it is determined by nature (biological) or nurture (social) is still debatable. The biological basis of gender identity cannot be modeled in animals and is best studied in people who identify with a gender that is different from the sex of their genitals such as transgender people and people with disorders/differences of sex development. Numerous research studies have delved into unraveling the intricate interplay of hormonal, neuroanatomic/neurofunctional, and genetic factors in the complex development of core gender identity. In this review, we explore and consolidate existing research that provides insights into the biological foundations of gender identity, enhancing our understanding of this intriguing human psychological trait.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000704&lng=en&tlng=enGender identitytransgendersex steroidsgeneticssex development
spellingShingle Rafael Loch Batista
Luciana Mattos Barros Oliveira
The genetics and hormonal basis of human gender identity
Archives of Endocrinology and Metabolism
Gender identity
transgender
sex steroids
genetics
sex development
title The genetics and hormonal basis of human gender identity
title_full The genetics and hormonal basis of human gender identity
title_fullStr The genetics and hormonal basis of human gender identity
title_full_unstemmed The genetics and hormonal basis of human gender identity
title_short The genetics and hormonal basis of human gender identity
title_sort genetics and hormonal basis of human gender identity
topic Gender identity
transgender
sex steroids
genetics
sex development
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000704&lng=en&tlng=en
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