The alert for emergence of pig-associated MRSA ST 398 in multi-regions China
Livestock-associated Methicillin-resistant Staphylococcus aureus (LA-MRSA) lineage ST398 presents a notable public health risk through its transmission from pigs to humans. This study characterizes phenotypic and genomic features of pig-associated MRSA ST398 isolates in China. Through surveillance (...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-12-01
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| Series: | One Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352771425001685 |
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| Summary: | Livestock-associated Methicillin-resistant Staphylococcus aureus (LA-MRSA) lineage ST398 presents a notable public health risk through its transmission from pigs to humans. This study characterizes phenotypic and genomic features of pig-associated MRSA ST398 isolates in China. Through surveillance (2015–2021) of 296 S. aureus isolates from major pork-producing regions, we identified 14 MRSA isolates in Zhejiang, Fujian, Guangdong, and Shanxi provinces, with 12 (85.7 %) belonging to the ST398 lineage. These isolates displayed two genetic profiles: t011-SCCmec V (10/12) and t571-SCCmec XII (2/12), and exhibited multidrug resistance to penicillin, oxacillin, cefoxitin, erythromycin, and clindamycin. Phylogenetic analysis revealed three critical findings: (1) clonal dissemination within Shanxi (0–48 SNPs), (2) potential interprovincial spread between geographically distant regions (Shanxi-Qinghai, 17–44 SNPs), and (3) concerning genetic linkage (70 SNPs) between a Zhejiang isolate and European ST398 isolate. These results underscore the urgent need for integrated pork supply chain surveillance strategies to monitor this emerging zoonotic pathogen. |
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| ISSN: | 2352-7714 |