Indication and Usefulness of Bile Juice Cytology for Diagnosis of Gallbladder Cancer
Aim. We examined the effectiveness of bile juice cytology for distinguishing between benign and malignant gallbladder lesions of the protruding type with various sampling points, sampling methods, and macroscopic forms in order to discuss the effectiveness of the endoscopic transpapillary gallbladde...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/5410349 |
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| author | Hiroshi Itsuki Masahiro Serikawa Tamito Sasaki Yasutaka Ishii Ken Tsushima Yoshinari Furukawa Yoshiaki Murakami Koji Arihiro Kazuaki Chayama |
| author_facet | Hiroshi Itsuki Masahiro Serikawa Tamito Sasaki Yasutaka Ishii Ken Tsushima Yoshinari Furukawa Yoshiaki Murakami Koji Arihiro Kazuaki Chayama |
| author_sort | Hiroshi Itsuki |
| collection | DOAJ |
| description | Aim. We examined the effectiveness of bile juice cytology for distinguishing between benign and malignant gallbladder lesions of the protruding type with various sampling points, sampling methods, and macroscopic forms in order to discuss the effectiveness of the endoscopic transpapillary gallbladder drainage (ETGD) cytology. Methods. We studied 162 cases of patients with a lesion localized within the gallbladder. At first, we examined the effectiveness for diagnosis of ETBD cytology using ERC and then that of the first ETGD cytology after placing the ETGD. Next, we examined the diagnostic effectiveness of the washed ETGD cytology by using the ETGD. Finally, we examined complications. Results. In the final diagnoses, we identified 33 cases of adenocarcinoma, 10 cases of adenoma, 63 cases of ADM, 35 cases of nonneoplastic polyp, and 21 cases of chronic cholecystitis. It was found that the sensitivity of ETBD cytology was 3.6% and that of ETGD cytology was 59.1%. In the comparison of diagnostic effectiveness of cytologic diagnosis using samples of bile juice from the gallbladder collected by different methods, the sensitivities were 38.9% and 73.3% for the first and washed ETGD cytologies, respectively. In the comparison of the diagnostic effectiveness of gallbladder bile juice cytology using samples collected for different forms of lesion and by different methods, the sensitivities were 38.9% and 73.3%, respectively, for the first and washed ETGD cytologies for flat gallbladder wall thickening, while it was impossible to diagnose for lesions of GB polyp. Conclusion. For diagnosis of gallbladder cancer, we consider that the ETGD cytology should be taken into consideration for lesions of flat gallbladder wall thickening, for which it is difficult to distinguish between benign and malignant lesions. |
| format | Article |
| id | doaj-art-bbe7ec0910414880af79dc283e4bf5db |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-bbe7ec0910414880af79dc283e4bf5db2025-02-03T06:41:58ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/54103495410349Indication and Usefulness of Bile Juice Cytology for Diagnosis of Gallbladder CancerHiroshi Itsuki0Masahiro Serikawa1Tamito Sasaki2Yasutaka Ishii3Ken Tsushima4Yoshinari Furukawa5Yoshiaki Murakami6Koji Arihiro7Kazuaki Chayama8Department of Gastroenterology and Metabolism, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, JapanDepartment of Gastroenterology and Metabolism, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, JapanDepartment of Gastroenterology, Hiroshima Prefectural Hospital, Hiroshima, JapanDepartment of Gastroenterology and Metabolism, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, JapanDepartment of Gastroenterology and Metabolism, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, JapanDepartment of Gastroenterology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima, JapanDepartment of Surgery, Applied Life Sciences Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanDepartment of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, JapanDepartment of Gastroenterology and Metabolism, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, JapanAim. We examined the effectiveness of bile juice cytology for distinguishing between benign and malignant gallbladder lesions of the protruding type with various sampling points, sampling methods, and macroscopic forms in order to discuss the effectiveness of the endoscopic transpapillary gallbladder drainage (ETGD) cytology. Methods. We studied 162 cases of patients with a lesion localized within the gallbladder. At first, we examined the effectiveness for diagnosis of ETBD cytology using ERC and then that of the first ETGD cytology after placing the ETGD. Next, we examined the diagnostic effectiveness of the washed ETGD cytology by using the ETGD. Finally, we examined complications. Results. In the final diagnoses, we identified 33 cases of adenocarcinoma, 10 cases of adenoma, 63 cases of ADM, 35 cases of nonneoplastic polyp, and 21 cases of chronic cholecystitis. It was found that the sensitivity of ETBD cytology was 3.6% and that of ETGD cytology was 59.1%. In the comparison of diagnostic effectiveness of cytologic diagnosis using samples of bile juice from the gallbladder collected by different methods, the sensitivities were 38.9% and 73.3% for the first and washed ETGD cytologies, respectively. In the comparison of the diagnostic effectiveness of gallbladder bile juice cytology using samples collected for different forms of lesion and by different methods, the sensitivities were 38.9% and 73.3%, respectively, for the first and washed ETGD cytologies for flat gallbladder wall thickening, while it was impossible to diagnose for lesions of GB polyp. Conclusion. For diagnosis of gallbladder cancer, we consider that the ETGD cytology should be taken into consideration for lesions of flat gallbladder wall thickening, for which it is difficult to distinguish between benign and malignant lesions.http://dx.doi.org/10.1155/2018/5410349 |
| spellingShingle | Hiroshi Itsuki Masahiro Serikawa Tamito Sasaki Yasutaka Ishii Ken Tsushima Yoshinari Furukawa Yoshiaki Murakami Koji Arihiro Kazuaki Chayama Indication and Usefulness of Bile Juice Cytology for Diagnosis of Gallbladder Cancer Gastroenterology Research and Practice |
| title | Indication and Usefulness of Bile Juice Cytology for Diagnosis of Gallbladder Cancer |
| title_full | Indication and Usefulness of Bile Juice Cytology for Diagnosis of Gallbladder Cancer |
| title_fullStr | Indication and Usefulness of Bile Juice Cytology for Diagnosis of Gallbladder Cancer |
| title_full_unstemmed | Indication and Usefulness of Bile Juice Cytology for Diagnosis of Gallbladder Cancer |
| title_short | Indication and Usefulness of Bile Juice Cytology for Diagnosis of Gallbladder Cancer |
| title_sort | indication and usefulness of bile juice cytology for diagnosis of gallbladder cancer |
| url | http://dx.doi.org/10.1155/2018/5410349 |
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