Harnessing exercise to combat chronic diseases: the role of Drp1-Mediated mitochondrial fission
Enhanced Drp1 activity mediates excessive mitochondrial fission, contributing to the onset and progression of various chronic diseases, including neurodegenerative, cardiovascular, and metabolic disorders. Studies indicate that exercise mitigates mitochondrial dysfunction by modulating Drp1-related...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1481756/full |
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| author | Yingxin Sun Junchen He Junchen He Lei Bao Xiaoming Shi Jinghong Wang Qingwen Li |
| author_facet | Yingxin Sun Junchen He Junchen He Lei Bao Xiaoming Shi Jinghong Wang Qingwen Li |
| author_sort | Yingxin Sun |
| collection | DOAJ |
| description | Enhanced Drp1 activity mediates excessive mitochondrial fission, contributing to the onset and progression of various chronic diseases, including neurodegenerative, cardiovascular, and metabolic disorders. Studies indicate that exercise mitigates mitochondrial dysfunction by modulating Drp1-related signaling targets, thereby inhibiting Drp1 activity and reducing excessive mitochondrial fission. This, in turn, enhances mitochondrial function and cellular metabolism. This review synthesizes the current understanding of Drp1 structure and activation mechanisms, and analyzes the effects of exercise interventions on Drp1-mediated mitochondrial fission in different disease models to improve common chronic conditions. This research deepens our insight into the specific mechanisms of Drp1-induced excessive mitochondrial fission in chronic disease pathogenesis, offering new theoretical support and practical guidance for exercise as a non-pharmacological intervention strategy. |
| format | Article |
| id | doaj-art-bbe21104871d44acbddbcdbdad02ebdf |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-bbe21104871d44acbddbcdbdad02ebdf2025-08-20T03:04:54ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-02-011310.3389/fcell.2025.14817561481756Harnessing exercise to combat chronic diseases: the role of Drp1-Mediated mitochondrial fissionYingxin Sun0Junchen He1Junchen He2Lei Bao3Xiaoming Shi4Jinghong Wang5Qingwen Li6School of Exercise and Health Sciences, Tianjin University of Sport, Tianjin, ChinaDepartment of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, ChinaDepartment of Dermatology, Tianjin lnstitute of lntegrative Dermatology, Tianjin, ChinaSchool of Exercise and Health Sciences, Tianjin University of Sport, Tianjin, ChinaSchool of Exercise and Health Sciences, Tianjin University of Sport, Tianjin, ChinaSchool of Exercise and Health Sciences, Tianjin University of Sport, Tianjin, ChinaSchool of Exercise and Health Sciences, Tianjin University of Sport, Tianjin, ChinaEnhanced Drp1 activity mediates excessive mitochondrial fission, contributing to the onset and progression of various chronic diseases, including neurodegenerative, cardiovascular, and metabolic disorders. Studies indicate that exercise mitigates mitochondrial dysfunction by modulating Drp1-related signaling targets, thereby inhibiting Drp1 activity and reducing excessive mitochondrial fission. This, in turn, enhances mitochondrial function and cellular metabolism. This review synthesizes the current understanding of Drp1 structure and activation mechanisms, and analyzes the effects of exercise interventions on Drp1-mediated mitochondrial fission in different disease models to improve common chronic conditions. This research deepens our insight into the specific mechanisms of Drp1-induced excessive mitochondrial fission in chronic disease pathogenesis, offering new theoretical support and practical guidance for exercise as a non-pharmacological intervention strategy.https://www.frontiersin.org/articles/10.3389/fcell.2025.1481756/fullphysical exercisemitochondrial fissionDrp1chronic diseasesmechanism |
| spellingShingle | Yingxin Sun Junchen He Junchen He Lei Bao Xiaoming Shi Jinghong Wang Qingwen Li Harnessing exercise to combat chronic diseases: the role of Drp1-Mediated mitochondrial fission Frontiers in Cell and Developmental Biology physical exercise mitochondrial fission Drp1 chronic diseases mechanism |
| title | Harnessing exercise to combat chronic diseases: the role of Drp1-Mediated mitochondrial fission |
| title_full | Harnessing exercise to combat chronic diseases: the role of Drp1-Mediated mitochondrial fission |
| title_fullStr | Harnessing exercise to combat chronic diseases: the role of Drp1-Mediated mitochondrial fission |
| title_full_unstemmed | Harnessing exercise to combat chronic diseases: the role of Drp1-Mediated mitochondrial fission |
| title_short | Harnessing exercise to combat chronic diseases: the role of Drp1-Mediated mitochondrial fission |
| title_sort | harnessing exercise to combat chronic diseases the role of drp1 mediated mitochondrial fission |
| topic | physical exercise mitochondrial fission Drp1 chronic diseases mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1481756/full |
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