Statins: Is it New Weaponry against Endometriosis?
Introduction: Endometriosis is a prevalent female illness linked to infertility and pelvic pain. In vitro studies suggest that statins reduce endometrial stroma growth and hinder angiogenesis. The objectives of this study were to assess if dienogest (DNZ) + atorvastatin (ATV) is more effective than...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Advances in Human Biology |
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| Online Access: | https://journals.lww.com/10.4103/aihb.aihb_25_25 |
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| author | Sharmin Salam Farzana Deeba Jesmin Banu Shakeela Ishrat Chandana Saha Susmita Sinha Pratiksha Patel Mainul Haque |
| author_facet | Sharmin Salam Farzana Deeba Jesmin Banu Shakeela Ishrat Chandana Saha Susmita Sinha Pratiksha Patel Mainul Haque |
| author_sort | Sharmin Salam |
| collection | DOAJ |
| description | Introduction:
Endometriosis is a prevalent female illness linked to infertility and pelvic pain. In vitro studies suggest that statins reduce endometrial stroma growth and hinder angiogenesis. The objectives of this study were to assess if dienogest (DNZ) + atorvastatin (ATV) is more effective than DNZ alone in women with symptomatic endometrioma.
Materials and Methods:
This prospective comparative study was done in the Department of Reproductive Endocrinology and Infertility, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh. Women with symptomatic endometrioma were enrolled in the study and were divided into the treatment arm of ATV plus DNZ and the control arm of DNZ alone. To examine the association between Group A (DNZ plus Statin) and Group B (DNZ) regarding the statistical model, a multilevel mixed-effects regression analysis was conducted to evaluate the relationship between the primary exposures, additional independent factors and outcomes such as endometrioma size and pain level.
Results:
Participants of Group A experienced infertility for more than 3 years than Group B, which was found statistically significant (P < 0.001). Again, a mixed-level regression analysis was conducted to assess the association between the primary exposure showed that post-intervention, endometrioma size decreased by 0.81 units (95% confidence interval [CI]: −1.10, −0.52, P < 0.001) and pain levels decreased by 3.81 units (95% CI: −4.31, −3.30, P < 0.001). Interestingly, pain levels were 1.64 units higher in the obese group (95% CI: 0.36, 2.92, P = 0.012). Amongst the participants reporting menstrual problems, endometrioma size was reduced by 0.92 units (95% CI: −1.32, −0.52, P < 0.001).
Conclusion:
The findings revealed that both treatment regimens efficiently lowered the size of endometriomas and relieved discomfort in the study subjects. |
| format | Article |
| id | doaj-art-bbd33bddfdfd410ba79ad44deccfd23f |
| institution | OA Journals |
| issn | 2321-8568 2348-4691 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advances in Human Biology |
| spelling | doaj-art-bbd33bddfdfd410ba79ad44deccfd23f2025-08-20T02:05:20ZengWolters Kluwer Medknow PublicationsAdvances in Human Biology2321-85682348-46912025-04-0115226727710.4103/aihb.aihb_25_25Statins: Is it New Weaponry against Endometriosis?Sharmin SalamFarzana DeebaJesmin BanuShakeela IshratChandana SahaSusmita SinhaPratiksha PatelMainul HaqueIntroduction: Endometriosis is a prevalent female illness linked to infertility and pelvic pain. In vitro studies suggest that statins reduce endometrial stroma growth and hinder angiogenesis. The objectives of this study were to assess if dienogest (DNZ) + atorvastatin (ATV) is more effective than DNZ alone in women with symptomatic endometrioma. Materials and Methods: This prospective comparative study was done in the Department of Reproductive Endocrinology and Infertility, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh. Women with symptomatic endometrioma were enrolled in the study and were divided into the treatment arm of ATV plus DNZ and the control arm of DNZ alone. To examine the association between Group A (DNZ plus Statin) and Group B (DNZ) regarding the statistical model, a multilevel mixed-effects regression analysis was conducted to evaluate the relationship between the primary exposures, additional independent factors and outcomes such as endometrioma size and pain level. Results: Participants of Group A experienced infertility for more than 3 years than Group B, which was found statistically significant (P < 0.001). Again, a mixed-level regression analysis was conducted to assess the association between the primary exposure showed that post-intervention, endometrioma size decreased by 0.81 units (95% confidence interval [CI]: −1.10, −0.52, P < 0.001) and pain levels decreased by 3.81 units (95% CI: −4.31, −3.30, P < 0.001). Interestingly, pain levels were 1.64 units higher in the obese group (95% CI: 0.36, 2.92, P = 0.012). Amongst the participants reporting menstrual problems, endometrioma size was reduced by 0.92 units (95% CI: −1.32, −0.52, P < 0.001). Conclusion: The findings revealed that both treatment regimens efficiently lowered the size of endometriomas and relieved discomfort in the study subjects.https://journals.lww.com/10.4103/aihb.aihb_25_25dienogestendometriomaendometriosisgynaecologyinfertilityobesityreproductive endocrinologyreproductive healthstatin-atorvastatinwomen |
| spellingShingle | Sharmin Salam Farzana Deeba Jesmin Banu Shakeela Ishrat Chandana Saha Susmita Sinha Pratiksha Patel Mainul Haque Statins: Is it New Weaponry against Endometriosis? Advances in Human Biology dienogest endometrioma endometriosis gynaecology infertility obesity reproductive endocrinology reproductive health statin-atorvastatin women |
| title | Statins: Is it New Weaponry against Endometriosis? |
| title_full | Statins: Is it New Weaponry against Endometriosis? |
| title_fullStr | Statins: Is it New Weaponry against Endometriosis? |
| title_full_unstemmed | Statins: Is it New Weaponry against Endometriosis? |
| title_short | Statins: Is it New Weaponry against Endometriosis? |
| title_sort | statins is it new weaponry against endometriosis |
| topic | dienogest endometrioma endometriosis gynaecology infertility obesity reproductive endocrinology reproductive health statin-atorvastatin women |
| url | https://journals.lww.com/10.4103/aihb.aihb_25_25 |
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