An Association between BK Virus Replication in Bone Marrow and Cytopenia in Kidney-Transplant Recipients
The human polyomavirus BK (BKV) is associated with severe complications, such as ureteric stenosis and polyomavirus-associated nephropathy (PVAN), which often occur in kidney-transplant patients. However, it is unknown if BKV can replicate within bone marrow. The aim of this study was to search for...
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Wiley
2014-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2014/252914 |
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| author | Emilie Pambrun Catherine Mengelle Geneviève Fillola Patrick Laharrague Laure Esposito Isabelle Cardeau-Desangles Arnaud Del Bello Jacques Izopet Lionel Rostaing Nassim Kamar |
| author_facet | Emilie Pambrun Catherine Mengelle Geneviève Fillola Patrick Laharrague Laure Esposito Isabelle Cardeau-Desangles Arnaud Del Bello Jacques Izopet Lionel Rostaing Nassim Kamar |
| author_sort | Emilie Pambrun |
| collection | DOAJ |
| description | The human polyomavirus BK (BKV) is associated with severe complications, such as ureteric stenosis and polyomavirus-associated nephropathy (PVAN), which often occur in kidney-transplant patients. However, it is unknown if BKV can replicate within bone marrow. The aim of this study was to search for BKV replication within the bone marrow of kidney-transplant patients presenting with a hematological disorder. Seventy-two kidney-transplant patients underwent bone-marrow aspiration for cytopenia. At least one virus was detected in the bone marrow of 25/72 patients (35%), that is, parvovirus B19 alone (n = 8), parvovirus plus Epstein-Barr virus (EBV) (n = 3), cytomegalovirus (n = 4), EBV (n = 2), BKV alone (n = 7), and BKV plus EBV (n = 1). Three of the eight patients who had BKV replication within the bone marrow had no detectable BKV replication in the blood. Neutropenia was observed in all patients with BKV replication in the bone marrow, and blockade of granulocyte maturation was observed. Hematological disorders disappeared in all patients after doses of immunosuppressants were reduced. In conclusion, an association between BKV replication in bone marrow and hematological disorders, especially neutropenia, was observed. Further studies are needed to confirm these findings. |
| format | Article |
| id | doaj-art-bbcfa67ef5af420ca1d06f2bbec3da84 |
| institution | DOAJ |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-bbcfa67ef5af420ca1d06f2bbec3da842025-08-20T03:22:54ZengWileyJournal of Transplantation2090-00072090-00152014-01-01201410.1155/2014/252914252914An Association between BK Virus Replication in Bone Marrow and Cytopenia in Kidney-Transplant RecipientsEmilie Pambrun0Catherine Mengelle1Geneviève Fillola2Patrick Laharrague3Laure Esposito4Isabelle Cardeau-Desangles5Arnaud Del Bello6Jacques Izopet7Lionel Rostaing8Nassim Kamar9Department of Nephrology and Organ Transplantation, CHU Rangueil, TSA 50032, 31059 Toulouse, FranceDepartment of Virology, CHU Purpan, 31059 Toulouse, FranceLaboratory of Haematology, CHU Rangueil, 31059 Toulouse, FranceLaboratory of Haematology, CHU Rangueil, 31059 Toulouse, FranceDepartment of Nephrology and Organ Transplantation, CHU Rangueil, TSA 50032, 31059 Toulouse, FranceDepartment of Nephrology and Organ Transplantation, CHU Rangueil, TSA 50032, 31059 Toulouse, FranceDepartment of Nephrology and Organ Transplantation, CHU Rangueil, TSA 50032, 31059 Toulouse, FranceDepartment of Virology, CHU Purpan, 31059 Toulouse, FranceDepartment of Nephrology and Organ Transplantation, CHU Rangueil, TSA 50032, 31059 Toulouse, FranceDepartment of Nephrology and Organ Transplantation, CHU Rangueil, TSA 50032, 31059 Toulouse, FranceThe human polyomavirus BK (BKV) is associated with severe complications, such as ureteric stenosis and polyomavirus-associated nephropathy (PVAN), which often occur in kidney-transplant patients. However, it is unknown if BKV can replicate within bone marrow. The aim of this study was to search for BKV replication within the bone marrow of kidney-transplant patients presenting with a hematological disorder. Seventy-two kidney-transplant patients underwent bone-marrow aspiration for cytopenia. At least one virus was detected in the bone marrow of 25/72 patients (35%), that is, parvovirus B19 alone (n = 8), parvovirus plus Epstein-Barr virus (EBV) (n = 3), cytomegalovirus (n = 4), EBV (n = 2), BKV alone (n = 7), and BKV plus EBV (n = 1). Three of the eight patients who had BKV replication within the bone marrow had no detectable BKV replication in the blood. Neutropenia was observed in all patients with BKV replication in the bone marrow, and blockade of granulocyte maturation was observed. Hematological disorders disappeared in all patients after doses of immunosuppressants were reduced. In conclusion, an association between BKV replication in bone marrow and hematological disorders, especially neutropenia, was observed. Further studies are needed to confirm these findings.http://dx.doi.org/10.1155/2014/252914 |
| spellingShingle | Emilie Pambrun Catherine Mengelle Geneviève Fillola Patrick Laharrague Laure Esposito Isabelle Cardeau-Desangles Arnaud Del Bello Jacques Izopet Lionel Rostaing Nassim Kamar An Association between BK Virus Replication in Bone Marrow and Cytopenia in Kidney-Transplant Recipients Journal of Transplantation |
| title | An Association between BK Virus Replication in Bone Marrow and Cytopenia in Kidney-Transplant Recipients |
| title_full | An Association between BK Virus Replication in Bone Marrow and Cytopenia in Kidney-Transplant Recipients |
| title_fullStr | An Association between BK Virus Replication in Bone Marrow and Cytopenia in Kidney-Transplant Recipients |
| title_full_unstemmed | An Association between BK Virus Replication in Bone Marrow and Cytopenia in Kidney-Transplant Recipients |
| title_short | An Association between BK Virus Replication in Bone Marrow and Cytopenia in Kidney-Transplant Recipients |
| title_sort | association between bk virus replication in bone marrow and cytopenia in kidney transplant recipients |
| url | http://dx.doi.org/10.1155/2014/252914 |
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