COMPUTATIONAL SCREENING TO IDENTIFY GENES INVOLVED IN DNA REPAIR IN ARABIDOPSIS THALIANA
The repair of damaged DNA is an essential function for living organisms. While great strides have been made in understanding this process in animal and yeast models, our knowledge in plant DNA repair is not as developed. Plants face many sources of DNA damage which they cannot so easily avoid: UV ra...
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| Format: | Article |
| Language: | English |
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Alexandru Ioan Cuza University of Iasi
2024-12-01
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| Series: | Journal of Plant Development |
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| Online Access: | https://plant-journal.uaic.ro/docs/2024/19.pdf |
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| author | James MORAN Tim XING |
| author_facet | James MORAN Tim XING |
| author_sort | James MORAN |
| collection | DOAJ |
| description | The repair of damaged DNA is an essential function for living organisms. While great strides have been made in understanding this process in animal and yeast models, our knowledge in plant DNA repair is not as developed. Plants face many sources of DNA damage which they cannot so easily avoid: UV radiation from sunlight, reactive oxygen species produced endogenously by their mitochondria and chloroplasts, reactive oxygen species accumulated while under conditions of cold, heat, or salt stress. Understanding plant DNA repair is particularly relevant as the accumulation of DNA damage can negatively impact the growth and yield of agronomically important species. In this study, a broad classification of genes related to DNA repair in the model dicot Arabidopsis thaliana was conducted using gene ontology and gene enrichment analysis. The results of this broad classification serve to elucidate pathways for further study in plant DNA damage response and repair. |
| format | Article |
| id | doaj-art-bbcb5233e3c54cccae79d55af57db5fa |
| institution | Kabale University |
| issn | 2065-3158 2066-9917 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Alexandru Ioan Cuza University of Iasi |
| record_format | Article |
| series | Journal of Plant Development |
| spelling | doaj-art-bbcb5233e3c54cccae79d55af57db5fa2025-01-20T06:00:57ZengAlexandru Ioan Cuza University of IasiJournal of Plant Development2065-31582066-99172024-12-0131215227https://doi.org/10.47743/jpd.2024.31.1.943COMPUTATIONAL SCREENING TO IDENTIFY GENES INVOLVED IN DNA REPAIR IN ARABIDOPSIS THALIANAJames MORAN0Tim XING1https://orcid.org/0000-0002-8325-0835Department of Biology and Institute of Biochemistry, Carleton University, Ottawa ON – CanadaDepartment of Biology and Institute of Biochemistry, Carleton University, Ottawa ON – CanadaThe repair of damaged DNA is an essential function for living organisms. While great strides have been made in understanding this process in animal and yeast models, our knowledge in plant DNA repair is not as developed. Plants face many sources of DNA damage which they cannot so easily avoid: UV radiation from sunlight, reactive oxygen species produced endogenously by their mitochondria and chloroplasts, reactive oxygen species accumulated while under conditions of cold, heat, or salt stress. Understanding plant DNA repair is particularly relevant as the accumulation of DNA damage can negatively impact the growth and yield of agronomically important species. In this study, a broad classification of genes related to DNA repair in the model dicot Arabidopsis thaliana was conducted using gene ontology and gene enrichment analysis. The results of this broad classification serve to elucidate pathways for further study in plant DNA damage response and repair.https://plant-journal.uaic.ro/docs/2024/19.pdfcell deathdna repairgene enrichment analysisgene ontologystress response |
| spellingShingle | James MORAN Tim XING COMPUTATIONAL SCREENING TO IDENTIFY GENES INVOLVED IN DNA REPAIR IN ARABIDOPSIS THALIANA Journal of Plant Development cell death dna repair gene enrichment analysis gene ontology stress response |
| title | COMPUTATIONAL SCREENING TO IDENTIFY GENES INVOLVED IN DNA REPAIR IN ARABIDOPSIS THALIANA |
| title_full | COMPUTATIONAL SCREENING TO IDENTIFY GENES INVOLVED IN DNA REPAIR IN ARABIDOPSIS THALIANA |
| title_fullStr | COMPUTATIONAL SCREENING TO IDENTIFY GENES INVOLVED IN DNA REPAIR IN ARABIDOPSIS THALIANA |
| title_full_unstemmed | COMPUTATIONAL SCREENING TO IDENTIFY GENES INVOLVED IN DNA REPAIR IN ARABIDOPSIS THALIANA |
| title_short | COMPUTATIONAL SCREENING TO IDENTIFY GENES INVOLVED IN DNA REPAIR IN ARABIDOPSIS THALIANA |
| title_sort | computational screening to identify genes involved in dna repair in arabidopsis thaliana |
| topic | cell death dna repair gene enrichment analysis gene ontology stress response |
| url | https://plant-journal.uaic.ro/docs/2024/19.pdf |
| work_keys_str_mv | AT jamesmoran computationalscreeningtoidentifygenesinvolvedindnarepairinarabidopsisthaliana AT timxing computationalscreeningtoidentifygenesinvolvedindnarepairinarabidopsisthaliana |