MSC-EXs inhibits uranium nephrotoxicity by competitively binding key proteins and inhibiting ROS production

MSC-EXs inhibits uranium nephrotoxicity by competitively binding key proteins and inhibiting ROS production

Uranium poisoning, particularly from exposure to Depleted Uranium (DU), occurs when uranyl ions enter the bloodstream and bind primarily to transferrin, osteopontin, and albumin before entering cells via corresponding receptors on renal tubular membranes, leading to cellular damage. Uranium poisonin...

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Bibliographic Details
Main Authors: Xinrui Yang, Jing Liu, Yaru Yin, Luxun Yang, Mingquan Gao, Zifei Wu, Binghui Lu, Shenglin Luo, Weidong Wang, Rong Li
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Uranium poisoning
Mesenchymal stem cells
Exosomes
Ferroptosis
Oxidative resistance
Renal toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324017305
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