Fractalkine and Other Chemokines in Primary Biliary Cirrhosis
Primary biliary cirrhosis (PBC) is characterized by the autoimmune injury of small intrahepatic bile duct. On this basis, it has been suggested that the targeted biliary epithelial cells (BEC) play an active role in the perpetuation of autoimmunity by attracting immune cells via chemokine secretion....
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/102839 |
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| _version_ | 1832554449832247296 |
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| author | Shinji Shimoda Carlo Selmi M. Eric Gershwin |
| author_facet | Shinji Shimoda Carlo Selmi M. Eric Gershwin |
| author_sort | Shinji Shimoda |
| collection | DOAJ |
| description | Primary biliary cirrhosis (PBC) is characterized by the autoimmune injury of small intrahepatic bile duct. On this basis, it has been suggested that the targeted biliary epithelial cells (BEC) play an active role in the perpetuation of autoimmunity by attracting immune cells via chemokine secretion. To address this issue, we challenged BEC using multiple toll-like receptor (TLR) ligands as well as autologous liver infiltrating mononuclear cells (LMNC) with subsequent measurement of BEC phenotype and chemokine production and LMNC chemotaxis by quantifying specific chemokines, specially CX3CL1 (fractalkine). We submit the hypothesis that BEC are in fact the innocent victims of the autoimmune injury and that the adaptive immune response is critical in PBC. |
| format | Article |
| id | doaj-art-bbbc37ab79d1475e8fe91edfec453ba3 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-bbbc37ab79d1475e8fe91edfec453ba32025-02-03T05:51:30ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/102839102839Fractalkine and Other Chemokines in Primary Biliary CirrhosisShinji Shimoda0Carlo Selmi1M. Eric Gershwin2Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Kyushu University, Fukuoka 819-0395, JapanDivision of Internal Medicine, IRCCS Istituto Clinico Humanitas, via A. Manzoni 56, Rozzano, 20089 Milan, ItalyDivision of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USAPrimary biliary cirrhosis (PBC) is characterized by the autoimmune injury of small intrahepatic bile duct. On this basis, it has been suggested that the targeted biliary epithelial cells (BEC) play an active role in the perpetuation of autoimmunity by attracting immune cells via chemokine secretion. To address this issue, we challenged BEC using multiple toll-like receptor (TLR) ligands as well as autologous liver infiltrating mononuclear cells (LMNC) with subsequent measurement of BEC phenotype and chemokine production and LMNC chemotaxis by quantifying specific chemokines, specially CX3CL1 (fractalkine). We submit the hypothesis that BEC are in fact the innocent victims of the autoimmune injury and that the adaptive immune response is critical in PBC.http://dx.doi.org/10.1155/2012/102839 |
| spellingShingle | Shinji Shimoda Carlo Selmi M. Eric Gershwin Fractalkine and Other Chemokines in Primary Biliary Cirrhosis International Journal of Hepatology |
| title | Fractalkine and Other Chemokines in Primary Biliary Cirrhosis |
| title_full | Fractalkine and Other Chemokines in Primary Biliary Cirrhosis |
| title_fullStr | Fractalkine and Other Chemokines in Primary Biliary Cirrhosis |
| title_full_unstemmed | Fractalkine and Other Chemokines in Primary Biliary Cirrhosis |
| title_short | Fractalkine and Other Chemokines in Primary Biliary Cirrhosis |
| title_sort | fractalkine and other chemokines in primary biliary cirrhosis |
| url | http://dx.doi.org/10.1155/2012/102839 |
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