Differential Impairment of Interferon-γ Responses in Two Cases of Pulmonary Nontuberculous Mycobacterial Disease
Nontuberculous mycobacteria (NTMs) are weakly virulent intracellular pathogens that are common in food and water supplies. The persistent culture of these organisms in the setting of clinical infection warrants investigation of immune function. In cases of isolated pulmonary NTM (PNTM) disease, unde...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2016/9165641 |
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| author | William Rae Yifang Gao Efrem Eren Rainer Döffinger Ben Marshall Anthony P. Williams |
| author_facet | William Rae Yifang Gao Efrem Eren Rainer Döffinger Ben Marshall Anthony P. Williams |
| author_sort | William Rae |
| collection | DOAJ |
| description | Nontuberculous mycobacteria (NTMs) are weakly virulent intracellular pathogens that are common in food and water supplies. The persistent culture of these organisms in the setting of clinical infection warrants investigation of immune function. In cases of isolated pulmonary NTM (PNTM) disease, underlying immune defects have not been clearly identified. We present two patients with isolated PNTM infection who demonstrated differentially impaired IFN-γ production across a range of stimuli. These cases show that cellular IFN-γ responses may be defective in a proportion of patient suffering PNTM disease and that when assessing responses, the stimulant used in the testing is important to delineate defective cell populations. Impaired IFN-γ responses to IL-12 + BCG seem to be a poor prognostic indicator in PNTM disease and in these cases were not improved by adjuvant IFN-γ. |
| format | Article |
| id | doaj-art-bb988066ed244aeea19b8c880340a873 |
| institution | Kabale University |
| issn | 2090-6609 2090-6617 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-bb988066ed244aeea19b8c880340a8732025-02-03T01:32:54ZengWileyCase Reports in Immunology2090-66092090-66172016-01-01201610.1155/2016/91656419165641Differential Impairment of Interferon-γ Responses in Two Cases of Pulmonary Nontuberculous Mycobacterial DiseaseWilliam Rae0Yifang Gao1Efrem Eren2Rainer Döffinger3Ben Marshall4Anthony P. Williams5University Hospital Southampton NHS Foundation Trust, Southampton, UKAcademic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton and Southampton NIHR Experimental Cancer Medicine Centre, Southampton, UKUniversity Hospital Southampton NHS Foundation Trust, Southampton, UKDepartment of Clinical Biochemistry and Immunology, Addenbrooke’s Hospital, Cambridge, UKUniversity Hospital Southampton NHS Foundation Trust, Southampton, UKUniversity Hospital Southampton NHS Foundation Trust, Southampton, UKNontuberculous mycobacteria (NTMs) are weakly virulent intracellular pathogens that are common in food and water supplies. The persistent culture of these organisms in the setting of clinical infection warrants investigation of immune function. In cases of isolated pulmonary NTM (PNTM) disease, underlying immune defects have not been clearly identified. We present two patients with isolated PNTM infection who demonstrated differentially impaired IFN-γ production across a range of stimuli. These cases show that cellular IFN-γ responses may be defective in a proportion of patient suffering PNTM disease and that when assessing responses, the stimulant used in the testing is important to delineate defective cell populations. Impaired IFN-γ responses to IL-12 + BCG seem to be a poor prognostic indicator in PNTM disease and in these cases were not improved by adjuvant IFN-γ.http://dx.doi.org/10.1155/2016/9165641 |
| spellingShingle | William Rae Yifang Gao Efrem Eren Rainer Döffinger Ben Marshall Anthony P. Williams Differential Impairment of Interferon-γ Responses in Two Cases of Pulmonary Nontuberculous Mycobacterial Disease Case Reports in Immunology |
| title | Differential Impairment of Interferon-γ Responses in Two Cases of Pulmonary Nontuberculous Mycobacterial Disease |
| title_full | Differential Impairment of Interferon-γ Responses in Two Cases of Pulmonary Nontuberculous Mycobacterial Disease |
| title_fullStr | Differential Impairment of Interferon-γ Responses in Two Cases of Pulmonary Nontuberculous Mycobacterial Disease |
| title_full_unstemmed | Differential Impairment of Interferon-γ Responses in Two Cases of Pulmonary Nontuberculous Mycobacterial Disease |
| title_short | Differential Impairment of Interferon-γ Responses in Two Cases of Pulmonary Nontuberculous Mycobacterial Disease |
| title_sort | differential impairment of interferon γ responses in two cases of pulmonary nontuberculous mycobacterial disease |
| url | http://dx.doi.org/10.1155/2016/9165641 |
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