Biomarkers of Acute Kidney Injury
Acute kidney injury (AKI) is a common problem in both the inpatient and outpatient setting and often results from drug toxicities. Traditional methods of identifying AKI, through measurement of blood urea nitrogen and serum creatinine, are problematic in that they are slow to detect decreases in glo...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2011/328120 |
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| author | Jeffrey C. Sirota Jelena Klawitter Charles L. Edelstein |
| author_facet | Jeffrey C. Sirota Jelena Klawitter Charles L. Edelstein |
| author_sort | Jeffrey C. Sirota |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is a common problem in both the inpatient and outpatient setting and often results from drug toxicities. Traditional methods of identifying AKI, through measurement of blood urea nitrogen and serum creatinine, are problematic in that they are slow to detect decreases in glomerular filtration rate (GFR) and are influenced by a variety of factors that are not related to GFR changes. The problems inherent in a creatinine-based diagnosis of AKI have impeded the development of proper therapeutics in AKI and posed problems in evaluating nephrotoxicity of drugs and other chemical exposures. In recent years, a number of new biomarkers of AKI with more favorable test characteristics than creatinine have been identified and studied in a variety of experimental and clinical settings. This review will consider the most well-established biomarkers and appraise the literature, with particular attention given to the use of biomarkers in identifying toxin-mediated AKI. |
| format | Article |
| id | doaj-art-bb90d9e20b5643ab89b6fd77d2782628 |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-bb90d9e20b5643ab89b6fd77d27826282025-02-03T01:01:48ZengWileyJournal of Toxicology1687-81911687-82052011-01-01201110.1155/2011/328120328120Biomarkers of Acute Kidney InjuryJeffrey C. Sirota0Jelena Klawitter1Charles L. Edelstein2Division of Renal Diseases & Hypertension, University of Colorado Health Sciences Center, Mail Stop C-281, 12700 East 19th Avenue, Aurora, CO 80045, USADepartment of Anesthesiology, University of Colorado Health Sciences Center, Mail Stop C-281, 12700 East 19th Avenue, Aurora, CO 80045, USADivision of Renal Diseases & Hypertension, University of Colorado Health Sciences Center, Mail Stop C-281, 12700 East 19th Avenue, Aurora, CO 80045, USAAcute kidney injury (AKI) is a common problem in both the inpatient and outpatient setting and often results from drug toxicities. Traditional methods of identifying AKI, through measurement of blood urea nitrogen and serum creatinine, are problematic in that they are slow to detect decreases in glomerular filtration rate (GFR) and are influenced by a variety of factors that are not related to GFR changes. The problems inherent in a creatinine-based diagnosis of AKI have impeded the development of proper therapeutics in AKI and posed problems in evaluating nephrotoxicity of drugs and other chemical exposures. In recent years, a number of new biomarkers of AKI with more favorable test characteristics than creatinine have been identified and studied in a variety of experimental and clinical settings. This review will consider the most well-established biomarkers and appraise the literature, with particular attention given to the use of biomarkers in identifying toxin-mediated AKI.http://dx.doi.org/10.1155/2011/328120 |
| spellingShingle | Jeffrey C. Sirota Jelena Klawitter Charles L. Edelstein Biomarkers of Acute Kidney Injury Journal of Toxicology |
| title | Biomarkers of Acute Kidney Injury |
| title_full | Biomarkers of Acute Kidney Injury |
| title_fullStr | Biomarkers of Acute Kidney Injury |
| title_full_unstemmed | Biomarkers of Acute Kidney Injury |
| title_short | Biomarkers of Acute Kidney Injury |
| title_sort | biomarkers of acute kidney injury |
| url | http://dx.doi.org/10.1155/2011/328120 |
| work_keys_str_mv | AT jeffreycsirota biomarkersofacutekidneyinjury AT jelenaklawitter biomarkersofacutekidneyinjury AT charlesledelstein biomarkersofacutekidneyinjury |