Cardiovascular manifestations in COVID-19 patients
Most important medical challenge during the past 2 years is the COVID-19 pandemic due to SARS-CoV-2 virus. COVID-19 morbidity is increased in the presence of CAD risk factors. Effect of CAD risk factors and COVID-19 infection are bidirectional. Preexisting conditions, such as cardiovascular disease...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-01-01
|
| Series: | Apollo Medicine |
| Subjects: | |
| Online Access: | http://www.apollomedicine.org/article.asp?issn=0976-0016;year=2022;volume=19;issue=3;spage=168;epage=176;aulast=Maddury |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832543384184553472 |
|---|---|
| author | Jyotsna Maddury Mani Krishna Achukatla Kumar |
| author_facet | Jyotsna Maddury Mani Krishna Achukatla Kumar |
| author_sort | Jyotsna Maddury |
| collection | DOAJ |
| description | Most important medical challenge during the past 2 years is the COVID-19 pandemic due to SARS-CoV-2 virus. COVID-19 morbidity is increased in the presence of CAD risk factors. Effect of CAD risk factors and COVID-19 infection are bidirectional. Preexisting conditions, such as cardiovascular disease (CVD), hypertension, diabetes, and obesity, increase the severity as well as mortality rate of COVID. COVID-19 disease induces multiple cardiovascular manifestations, such as myocarditis, acute myocardial injury, acute myocardial infarction (MI), stress-induced cardiomyopathy, cardiogenic shock, arrhythmias, and, subsequently, heart failure (HF) and cardiac arrest. Increase of troponin suggests a hyperinflammatory state or may be due to acute myocarditis. Elevated troponin without other laboratory markers elevation suggests aggressive COVID-19 disease than myocardial injury. Stress or takotsubo cardiomyopathy occurred primarily in women with COVID-19 and these women have more severe HF. The patients with COVID-19 positive more frequently have multivessel thrombosis, stent thrombosis, and a higher thrombus when compared to COVID-19-negative STEMIs. Because of higher thrombus burden more usage of glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors and thrombus aspiration and higher heparin doses to achieve therapeutic activated clotting times were also noted. Patients with pulmonary embolism had significantly higher hs-cTnT and NT pro-BNP levels than those without pulmonary embolism. In COVID-19, arrhythmias noticed are atrioventricular/ventricular block, sinus tachycardia, sinus bradycardia, atrial arrhythmias, and ventricular arrhythmias. Consideration for potential drug interactions should be taken when treating CVD patients with COVID-19. |
| format | Article |
| id | doaj-art-bb8d3016df1c46d491d0d3fd5fb767ff |
| institution | Kabale University |
| issn | 0976-0016 2213-3682 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Apollo Medicine |
| spelling | doaj-art-bb8d3016df1c46d491d0d3fd5fb767ff2025-02-03T11:48:20ZengSAGE PublishingApollo Medicine0976-00162213-36822022-01-0119316817610.4103/am.am_24_22Cardiovascular manifestations in COVID-19 patientsJyotsna MadduryMani KrishnaAchukatla KumarMost important medical challenge during the past 2 years is the COVID-19 pandemic due to SARS-CoV-2 virus. COVID-19 morbidity is increased in the presence of CAD risk factors. Effect of CAD risk factors and COVID-19 infection are bidirectional. Preexisting conditions, such as cardiovascular disease (CVD), hypertension, diabetes, and obesity, increase the severity as well as mortality rate of COVID. COVID-19 disease induces multiple cardiovascular manifestations, such as myocarditis, acute myocardial injury, acute myocardial infarction (MI), stress-induced cardiomyopathy, cardiogenic shock, arrhythmias, and, subsequently, heart failure (HF) and cardiac arrest. Increase of troponin suggests a hyperinflammatory state or may be due to acute myocarditis. Elevated troponin without other laboratory markers elevation suggests aggressive COVID-19 disease than myocardial injury. Stress or takotsubo cardiomyopathy occurred primarily in women with COVID-19 and these women have more severe HF. The patients with COVID-19 positive more frequently have multivessel thrombosis, stent thrombosis, and a higher thrombus when compared to COVID-19-negative STEMIs. Because of higher thrombus burden more usage of glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors and thrombus aspiration and higher heparin doses to achieve therapeutic activated clotting times were also noted. Patients with pulmonary embolism had significantly higher hs-cTnT and NT pro-BNP levels than those without pulmonary embolism. In COVID-19, arrhythmias noticed are atrioventricular/ventricular block, sinus tachycardia, sinus bradycardia, atrial arrhythmias, and ventricular arrhythmias. Consideration for potential drug interactions should be taken when treating CVD patients with COVID-19.http://www.apollomedicine.org/article.asp?issn=0976-0016;year=2022;volume=19;issue=3;spage=168;epage=176;aulast=Madduryarrhythmiacovid-19myocardial infarctionmyocarditisrecommendations |
| spellingShingle | Jyotsna Maddury Mani Krishna Achukatla Kumar Cardiovascular manifestations in COVID-19 patients Apollo Medicine arrhythmia covid-19 myocardial infarction myocarditis recommendations |
| title | Cardiovascular manifestations in COVID-19 patients |
| title_full | Cardiovascular manifestations in COVID-19 patients |
| title_fullStr | Cardiovascular manifestations in COVID-19 patients |
| title_full_unstemmed | Cardiovascular manifestations in COVID-19 patients |
| title_short | Cardiovascular manifestations in COVID-19 patients |
| title_sort | cardiovascular manifestations in covid 19 patients |
| topic | arrhythmia covid-19 myocardial infarction myocarditis recommendations |
| url | http://www.apollomedicine.org/article.asp?issn=0976-0016;year=2022;volume=19;issue=3;spage=168;epage=176;aulast=Maddury |
| work_keys_str_mv | AT jyotsnamaddury cardiovascularmanifestationsincovid19patients AT manikrishna cardiovascularmanifestationsincovid19patients AT achukatlakumar cardiovascularmanifestationsincovid19patients |