Fluorescence molecular imaging-guided photodynamic therapy for early breast cancer in the prone position: Feasibility evaluation with Monte Carlo simulations
Introduction: The successful diagnosis and treatment of early-stage breast cancer enhances the quality of life of patients. As a promising alternative to recently developed magnetic resonance imaging-guided radiotherapy, we proposed fluorescence molecular imaging-guided photodynamic therapy (FMI-gui...
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Elsevier
2025-04-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025000286 |
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| author | Yugo Minegishi Yasutomo Nomura |
| author_facet | Yugo Minegishi Yasutomo Nomura |
| author_sort | Yugo Minegishi |
| collection | DOAJ |
| description | Introduction: The successful diagnosis and treatment of early-stage breast cancer enhances the quality of life of patients. As a promising alternative to recently developed magnetic resonance imaging-guided radiotherapy, we proposed fluorescence molecular imaging-guided photodynamic therapy (FMI-guided PDT), which requires no expensive equipment. In the FMI simulations, ICG-C11 which has emission peaks at near-infrared wavelengths was used as the FMI agent. In the PDT simulation, Upconversion nanoparticles-Quantum dots-Rose bengal (UCQR) which was a PDT agent with upconversion capabilities was used. Methods: The feasibility of breast cancer diagnosis and treatment using our proposed method is evaluated through Monte Carlo simulations of exact light transport through a realistic breast model in the prone position. Monte Carlo modeling in voxelized media was performed. Fluorescence propagation from the tumor and the amount of singlet oxygen produced within the tumor were estimated from the calculated fluence. Next, the effects of tumor diameter and depth from the skin surface on the simulation results were evaluated. Results: The simulation results showed successful detection of tumors with diameters of 5–9 mm in the 15–25 mm depth region, where tumors are commonly found. Furthermore, simulations have estimated that those tumors can be completely treated by PDT with less than ten light irradiations. Conclusion: This study suggests that fluorescent molecular imaging-guided photodynamic therapy may be a potential treatment for early-stage breast cancer. Our method would be more suitable than the conventional method for young women who are at higher risk of radiation exposure effects. |
| format | Article |
| id | doaj-art-bb82fe25e789432c90fddf1ccdb1d84c |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-bb82fe25e789432c90fddf1ccdb1d84c2025-02-04T04:10:21ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-04-0152104498Fluorescence molecular imaging-guided photodynamic therapy for early breast cancer in the prone position: Feasibility evaluation with Monte Carlo simulationsYugo Minegishi0Yasutomo Nomura1Maebashi-Institute of Technology, Systems Life Engineering, Gunma, 371-0816 JapanCorresponding author at: Maebashi-Institute of Technology, Systems Life Engineering, Gunma, 371-0816 Japan.; Maebashi-Institute of Technology, Systems Life Engineering, Gunma, 371-0816 JapanIntroduction: The successful diagnosis and treatment of early-stage breast cancer enhances the quality of life of patients. As a promising alternative to recently developed magnetic resonance imaging-guided radiotherapy, we proposed fluorescence molecular imaging-guided photodynamic therapy (FMI-guided PDT), which requires no expensive equipment. In the FMI simulations, ICG-C11 which has emission peaks at near-infrared wavelengths was used as the FMI agent. In the PDT simulation, Upconversion nanoparticles-Quantum dots-Rose bengal (UCQR) which was a PDT agent with upconversion capabilities was used. Methods: The feasibility of breast cancer diagnosis and treatment using our proposed method is evaluated through Monte Carlo simulations of exact light transport through a realistic breast model in the prone position. Monte Carlo modeling in voxelized media was performed. Fluorescence propagation from the tumor and the amount of singlet oxygen produced within the tumor were estimated from the calculated fluence. Next, the effects of tumor diameter and depth from the skin surface on the simulation results were evaluated. Results: The simulation results showed successful detection of tumors with diameters of 5–9 mm in the 15–25 mm depth region, where tumors are commonly found. Furthermore, simulations have estimated that those tumors can be completely treated by PDT with less than ten light irradiations. Conclusion: This study suggests that fluorescent molecular imaging-guided photodynamic therapy may be a potential treatment for early-stage breast cancer. Our method would be more suitable than the conventional method for young women who are at higher risk of radiation exposure effects.http://www.sciencedirect.com/science/article/pii/S1572100025000286Fluorescence molecular imagingPhotodynamic therapyNear infraredEarly breast cancerProne positionMonte carlo simulation |
| spellingShingle | Yugo Minegishi Yasutomo Nomura Fluorescence molecular imaging-guided photodynamic therapy for early breast cancer in the prone position: Feasibility evaluation with Monte Carlo simulations Photodiagnosis and Photodynamic Therapy Fluorescence molecular imaging Photodynamic therapy Near infrared Early breast cancer Prone position Monte carlo simulation |
| title | Fluorescence molecular imaging-guided photodynamic therapy for early breast cancer in the prone position: Feasibility evaluation with Monte Carlo simulations |
| title_full | Fluorescence molecular imaging-guided photodynamic therapy for early breast cancer in the prone position: Feasibility evaluation with Monte Carlo simulations |
| title_fullStr | Fluorescence molecular imaging-guided photodynamic therapy for early breast cancer in the prone position: Feasibility evaluation with Monte Carlo simulations |
| title_full_unstemmed | Fluorescence molecular imaging-guided photodynamic therapy for early breast cancer in the prone position: Feasibility evaluation with Monte Carlo simulations |
| title_short | Fluorescence molecular imaging-guided photodynamic therapy for early breast cancer in the prone position: Feasibility evaluation with Monte Carlo simulations |
| title_sort | fluorescence molecular imaging guided photodynamic therapy for early breast cancer in the prone position feasibility evaluation with monte carlo simulations |
| topic | Fluorescence molecular imaging Photodynamic therapy Near infrared Early breast cancer Prone position Monte carlo simulation |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025000286 |
| work_keys_str_mv | AT yugominegishi fluorescencemolecularimagingguidedphotodynamictherapyforearlybreastcancerinthepronepositionfeasibilityevaluationwithmontecarlosimulations AT yasutomonomura fluorescencemolecularimagingguidedphotodynamictherapyforearlybreastcancerinthepronepositionfeasibilityevaluationwithmontecarlosimulations |