2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks
Mammalian cells have a well-defined set of antioxidant enzymes, which includes superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins. Peroxiredoxins are the most recently identified family of antioxidant enzymes that catalyze the reduction reaction of peroxides, such as H2O2....
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2014/715867 |
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| author | Jinah Park Sunmi Lee Sanghyuk Lee Sang Won Kang |
| author_facet | Jinah Park Sunmi Lee Sanghyuk Lee Sang Won Kang |
| author_sort | Jinah Park |
| collection | DOAJ |
| description | Mammalian cells have a well-defined set of antioxidant enzymes, which includes superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins. Peroxiredoxins are the most recently identified family of antioxidant enzymes that catalyze the reduction reaction of peroxides, such as H2O2. In particular, typical 2-Cys peroxiredoxins are the featured peroxidase enzymes that receive the electrons from NADPH by coupling with thioredoxin and thioredoxin reductase. These enzymes distribute throughout the cellular compartments and, therefore, are thought to be broad-range antioxidant defenders. However, recent evidence demonstrates that typical 2-Cys peroxiredoxins play key signal regulatory roles in the various signaling networks by interacting with or residing near a specific redox-sensitive molecule. These discoveries help reveal the redox signaling landscape in mammalian cells and may further provide a new paradigm of therapeutic approaches based on redox signaling. |
| format | Article |
| id | doaj-art-bb800c7e9fce49f48469506d9494b403 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-bb800c7e9fce49f48469506d9494b4032025-02-03T05:52:15ZengWileyInternational Journal of Cell Biology1687-88761687-88842014-01-01201410.1155/2014/7158677158672-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling NetworksJinah Park0Sunmi Lee1Sanghyuk Lee2Sang Won Kang3Korean Bioinformation Center, KRIBB, Daejeon 305-806, Republic of KoreaDepartment of Life Science and Research Center for Cell Homeostasis, Ewha Womans University, 52 Ewhayeodaegil, Seodaemun-gu, Seoul 120-750, Republic of KoreaDepartment of Life Science and Research Center for Cell Homeostasis, Ewha Womans University, 52 Ewhayeodaegil, Seodaemun-gu, Seoul 120-750, Republic of KoreaDepartment of Life Science and Research Center for Cell Homeostasis, Ewha Womans University, 52 Ewhayeodaegil, Seodaemun-gu, Seoul 120-750, Republic of KoreaMammalian cells have a well-defined set of antioxidant enzymes, which includes superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins. Peroxiredoxins are the most recently identified family of antioxidant enzymes that catalyze the reduction reaction of peroxides, such as H2O2. In particular, typical 2-Cys peroxiredoxins are the featured peroxidase enzymes that receive the electrons from NADPH by coupling with thioredoxin and thioredoxin reductase. These enzymes distribute throughout the cellular compartments and, therefore, are thought to be broad-range antioxidant defenders. However, recent evidence demonstrates that typical 2-Cys peroxiredoxins play key signal regulatory roles in the various signaling networks by interacting with or residing near a specific redox-sensitive molecule. These discoveries help reveal the redox signaling landscape in mammalian cells and may further provide a new paradigm of therapeutic approaches based on redox signaling.http://dx.doi.org/10.1155/2014/715867 |
| spellingShingle | Jinah Park Sunmi Lee Sanghyuk Lee Sang Won Kang 2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks International Journal of Cell Biology |
| title | 2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks |
| title_full | 2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks |
| title_fullStr | 2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks |
| title_full_unstemmed | 2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks |
| title_short | 2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks |
| title_sort | 2 cys peroxiredoxins emerging hubs determining redox dependency of mammalian signaling networks |
| url | http://dx.doi.org/10.1155/2014/715867 |
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