The application of photodynamic therapy in recurrent genital herpes
Background: Frequently, recurrence of genital herpes imposes significant physical and psychological burdens on patients, and existing treatments are often ineffective in preventing recurrence. Previous studies have indicated that photodynamic therapy (PDT) showed promising outcomes in the treatment...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S157210002400423X |
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| author | Jinyi Chen Yuancheng Li Dechao Li Nian Chen Wen Ding Ting Zou Yang Tan Xia Lei |
| author_facet | Jinyi Chen Yuancheng Li Dechao Li Nian Chen Wen Ding Ting Zou Yang Tan Xia Lei |
| author_sort | Jinyi Chen |
| collection | DOAJ |
| description | Background: Frequently, recurrence of genital herpes imposes significant physical and psychological burdens on patients, and existing treatments are often ineffective in preventing recurrence. Previous studies have indicated that photodynamic therapy (PDT) showed promising outcomes in the treatment of labial herpes simplex virus (HSV) infections; however, its efficacy for genital herpes remained unclear. Method: The study screened patients with genital herpes at Daping Hospital from July 2020 to May 2024. Patients were divided into two groups based on whether they received PDT treatment. Over a one-year follow-up period, patients' healing time and recurrence rates were compared between the two groups. The cumulative incidence of recurrence and restricted mean survival time (RMST) were used to assess outcomes. Propensity score matching (PSM) was employed to minimize bias. Result: A total of 41 patients enrolled in our study, with 8 (19.5 %) received PDT. The non-PDT group exhibited a slower skin lesion healing time, averaging at 7.2 days compared to 5.4 days in the PDT group. A significant difference was observed in the cumulative incidence of recurrence between the PDT and non-PDT groups (37.5 % versus 71.4 %) after PSM. The RMST in the PDT group was 9.94 days, compared to 5.13 days in the non-PDT group before PSM, and 4.14 after PSM. Conclusion: Our study demonstrated that the PDT effectively reduced lesion recovery time and delayed recurrences of genital herpes. We recommend considering PDT as a potential treatment option for patients with recurrent genital herpes. |
| format | Article |
| id | doaj-art-bb7f19aa035b4d15b2bc77e6297b09e8 |
| institution | DOAJ |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-bb7f19aa035b4d15b2bc77e6297b09e82025-08-20T02:49:53ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-12-015010438610.1016/j.pdpdt.2024.104386The application of photodynamic therapy in recurrent genital herpesJinyi Chen0Yuancheng Li1Dechao Li2Nian Chen3Wen Ding4Ting Zou5Yang Tan6Xia Lei7Department of Dermatology, Daping Hospital, Army Medical University(Third Military Medical University), No.10, Yangtze River Branch Road, Daping, Yuzhong District, Chongqing, 400042, China; Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China; Engineering Research Center of the Ministry of Education for Tissue and Organ Regeneration and Manufacturing, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, ChinaDepartment of Dermatology, Daping Hospital, Army Medical University(Third Military Medical University), No.10, Yangtze River Branch Road, Daping, Yuzhong District, Chongqing, 400042, China; Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China; Engineering Research Center of the Ministry of Education for Tissue and Organ Regeneration and Manufacturing, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, ChinaDepartment of Dermatology, Daping Hospital, Army Medical University(Third Military Medical University), No.10, Yangtze River Branch Road, Daping, Yuzhong District, Chongqing, 400042, China; Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China; Engineering Research Center of the Ministry of Education for Tissue and Organ Regeneration and Manufacturing, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, ChinaDepartment of Dermatology, Daping Hospital, Army Medical University(Third Military Medical University), No.10, Yangtze River Branch Road, Daping, Yuzhong District, Chongqing, 400042, China; Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China; Engineering Research Center of the Ministry of Education for Tissue and Organ Regeneration and Manufacturing, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, ChinaDepartment of Dermatology, Daping Hospital, Army Medical University(Third Military Medical University), No.10, Yangtze River Branch Road, Daping, Yuzhong District, Chongqing, 400042, China; Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China; Engineering Research Center of the Ministry of Education for Tissue and Organ Regeneration and Manufacturing, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, ChinaDepartment of Dermatology, Daping Hospital, Army Medical University(Third Military Medical University), No.10, Yangtze River Branch Road, Daping, Yuzhong District, Chongqing, 400042, China; Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China; Engineering Research Center of the Ministry of Education for Tissue and Organ Regeneration and Manufacturing, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, ChinaCorresponding authors.; Department of Dermatology, Daping Hospital, Army Medical University(Third Military Medical University), No.10, Yangtze River Branch Road, Daping, Yuzhong District, Chongqing, 400042, China; Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China; Engineering Research Center of the Ministry of Education for Tissue and Organ Regeneration and Manufacturing, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, ChinaCorresponding authors.; Department of Dermatology, Daping Hospital, Army Medical University(Third Military Medical University), No.10, Yangtze River Branch Road, Daping, Yuzhong District, Chongqing, 400042, China; Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China; Engineering Research Center of the Ministry of Education for Tissue and Organ Regeneration and Manufacturing, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, ChinaBackground: Frequently, recurrence of genital herpes imposes significant physical and psychological burdens on patients, and existing treatments are often ineffective in preventing recurrence. Previous studies have indicated that photodynamic therapy (PDT) showed promising outcomes in the treatment of labial herpes simplex virus (HSV) infections; however, its efficacy for genital herpes remained unclear. Method: The study screened patients with genital herpes at Daping Hospital from July 2020 to May 2024. Patients were divided into two groups based on whether they received PDT treatment. Over a one-year follow-up period, patients' healing time and recurrence rates were compared between the two groups. The cumulative incidence of recurrence and restricted mean survival time (RMST) were used to assess outcomes. Propensity score matching (PSM) was employed to minimize bias. Result: A total of 41 patients enrolled in our study, with 8 (19.5 %) received PDT. The non-PDT group exhibited a slower skin lesion healing time, averaging at 7.2 days compared to 5.4 days in the PDT group. A significant difference was observed in the cumulative incidence of recurrence between the PDT and non-PDT groups (37.5 % versus 71.4 %) after PSM. The RMST in the PDT group was 9.94 days, compared to 5.13 days in the non-PDT group before PSM, and 4.14 after PSM. Conclusion: Our study demonstrated that the PDT effectively reduced lesion recovery time and delayed recurrences of genital herpes. We recommend considering PDT as a potential treatment option for patients with recurrent genital herpes.http://www.sciencedirect.com/science/article/pii/S157210002400423XHerpes simplex virusGenital herpesPhotodynamic therapyOutcomes |
| spellingShingle | Jinyi Chen Yuancheng Li Dechao Li Nian Chen Wen Ding Ting Zou Yang Tan Xia Lei The application of photodynamic therapy in recurrent genital herpes Photodiagnosis and Photodynamic Therapy Herpes simplex virus Genital herpes Photodynamic therapy Outcomes |
| title | The application of photodynamic therapy in recurrent genital herpes |
| title_full | The application of photodynamic therapy in recurrent genital herpes |
| title_fullStr | The application of photodynamic therapy in recurrent genital herpes |
| title_full_unstemmed | The application of photodynamic therapy in recurrent genital herpes |
| title_short | The application of photodynamic therapy in recurrent genital herpes |
| title_sort | application of photodynamic therapy in recurrent genital herpes |
| topic | Herpes simplex virus Genital herpes Photodynamic therapy Outcomes |
| url | http://www.sciencedirect.com/science/article/pii/S157210002400423X |
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