Enhancing Plasticity of the Central Nervous System: Drugs, Stem Cell Therapy, and Neuro-Implants
Stroke represents the first cause of adult acquired disability. Spontaneous recovery, dependent on endogenous neurogenesis, allows for limited recovery in 50% of patients who remain functionally dependent despite physiotherapy. Here, we propose a review of novel drug therapies with strong potential...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/2545736 |
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| author | Alice Le Friec Anne-Sophie Salabert Carole Davoust Boris Demain Christophe Vieu Laurence Vaysse Pierre Payoux Isabelle Loubinoux |
| author_facet | Alice Le Friec Anne-Sophie Salabert Carole Davoust Boris Demain Christophe Vieu Laurence Vaysse Pierre Payoux Isabelle Loubinoux |
| author_sort | Alice Le Friec |
| collection | DOAJ |
| description | Stroke represents the first cause of adult acquired disability. Spontaneous recovery, dependent on endogenous neurogenesis, allows for limited recovery in 50% of patients who remain functionally dependent despite physiotherapy. Here, we propose a review of novel drug therapies with strong potential in the clinic. We will also discuss new avenues of stem cell therapy in patients with a cerebral lesion. A promising future for the development of efficient drugs to enhance functional recovery after stroke seems evident. These drugs will have to prove their efficacy also in severely affected patients. The efficacy of stem cell engraftment has been demonstrated but will have to prove its potential in restoring tissue function for the massive brain lesions that are most debilitating. New answers may lay in biomaterials, a steadily growing field. Biomaterials should ideally resemble lesioned brain structures in architecture and must be proven to increase functional reconnections within host tissue before clinical testing. |
| format | Article |
| id | doaj-art-bb6e0dcfdc624600b57f127279698c33 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-bb6e0dcfdc624600b57f127279698c332025-02-03T06:07:11ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/25457362545736Enhancing Plasticity of the Central Nervous System: Drugs, Stem Cell Therapy, and Neuro-ImplantsAlice Le Friec0Anne-Sophie Salabert1Carole Davoust2Boris Demain3Christophe Vieu4Laurence Vaysse5Pierre Payoux6Isabelle Loubinoux7ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, FranceToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, FranceToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, FranceToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, FranceLAAS-CNRS, Université de Toulouse, CNRS, INSA, UPS, Toulouse, FranceToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, FranceToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, FranceToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, FranceStroke represents the first cause of adult acquired disability. Spontaneous recovery, dependent on endogenous neurogenesis, allows for limited recovery in 50% of patients who remain functionally dependent despite physiotherapy. Here, we propose a review of novel drug therapies with strong potential in the clinic. We will also discuss new avenues of stem cell therapy in patients with a cerebral lesion. A promising future for the development of efficient drugs to enhance functional recovery after stroke seems evident. These drugs will have to prove their efficacy also in severely affected patients. The efficacy of stem cell engraftment has been demonstrated but will have to prove its potential in restoring tissue function for the massive brain lesions that are most debilitating. New answers may lay in biomaterials, a steadily growing field. Biomaterials should ideally resemble lesioned brain structures in architecture and must be proven to increase functional reconnections within host tissue before clinical testing.http://dx.doi.org/10.1155/2017/2545736 |
| spellingShingle | Alice Le Friec Anne-Sophie Salabert Carole Davoust Boris Demain Christophe Vieu Laurence Vaysse Pierre Payoux Isabelle Loubinoux Enhancing Plasticity of the Central Nervous System: Drugs, Stem Cell Therapy, and Neuro-Implants Neural Plasticity |
| title | Enhancing Plasticity of the Central Nervous System: Drugs, Stem Cell Therapy, and Neuro-Implants |
| title_full | Enhancing Plasticity of the Central Nervous System: Drugs, Stem Cell Therapy, and Neuro-Implants |
| title_fullStr | Enhancing Plasticity of the Central Nervous System: Drugs, Stem Cell Therapy, and Neuro-Implants |
| title_full_unstemmed | Enhancing Plasticity of the Central Nervous System: Drugs, Stem Cell Therapy, and Neuro-Implants |
| title_short | Enhancing Plasticity of the Central Nervous System: Drugs, Stem Cell Therapy, and Neuro-Implants |
| title_sort | enhancing plasticity of the central nervous system drugs stem cell therapy and neuro implants |
| url | http://dx.doi.org/10.1155/2017/2545736 |
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