Three New Depsipeptides, Homiamides A–C, Isolated from <i>Streptomyces</i> sp., ROA-065

Three New Depsipeptides, Homiamides A–C, Isolated from <i>Streptomyces</i> sp., ROA-065

Three new depsipeptides, homiamides A–C (<b>1</b>–<b>3</b>), were isolated from a marine sediment-derived strain of <i>Streptomyces</i> sp., ROA-065. The planar structures of homiamides A–C (<b>1</b>–<b>3</b>) were elucidated using mass spe...

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Bibliographic Details
Main Authors:	Jeong-Hyeon Kim, Ji Young Lee, Juri Lee, Prima F. Hillman, Jihye Lee, Byeongchan Choi, Man-Jeong Paik, Songyi Lee, Sang-Jip Nam
Format:	Article
Language:	English
Published:	MDPI AG 2024-11-01
Series:	Molecules
Subjects:	<i>Streptomyces</i> depsipeptide antibacterial activity Marfey’s method gas chromatography mass spectrometry
Online Access:	https://www.mdpi.com/1420-3049/29/23/5539
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Summary:	Three new depsipeptides, homiamides A–C (<b>1</b>–<b>3</b>), were isolated from a marine sediment-derived strain of <i>Streptomyces</i> sp., ROA-065. The planar structures of homiamides A–C (<b>1</b>–<b>3</b>) were elucidated using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data. The absolute configurations of <b>1</b>–<b>3</b> were deduced from the application of the Marfey’s method and GC-MS analysis after formation of the <i>O</i>-trifluoroacetylated (<i>S</i>)-(+)-methyl-2-butyl ester derivatives of amino acids. Compounds <b>1</b>–<b>3</b> exhibited weak anti-bacterial activities against both Gram-positive bacteria and Gram-negative bacteria, with compound <b>1</b> showing MIC values of 32–64 μg/mL. In antifouling assays, compounds <b>1</b> and <b>2</b> displayed moderate activity against <i>Micrococcus luteus</i> KCTC 3063, while compound <b>3</b> exhibited weak activity against all tested bacteria.
ISSN:	1420-3049