Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer
Abstract Circular RNAs (circRNAs) have garnered substantial attention due to their distinctive circular structure and gene regulatory functions, establishing them as a significant class of functional non-coding RNAs in eukaryotes. Studies have demonstrated that circRNAs can interact with RNA-binding...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07383-z |
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| author | Nan Zhang Xinjia Wang Yu Li Yiwei Lu Chengcheng Sheng Yumeng Sun Ningye Ma Yisheng Jiao |
| author_facet | Nan Zhang Xinjia Wang Yu Li Yiwei Lu Chengcheng Sheng Yumeng Sun Ningye Ma Yisheng Jiao |
| author_sort | Nan Zhang |
| collection | DOAJ |
| description | Abstract Circular RNAs (circRNAs) have garnered substantial attention due to their distinctive circular structure and gene regulatory functions, establishing them as a significant class of functional non-coding RNAs in eukaryotes. Studies have demonstrated that circRNAs can interact with RNA-binding proteins (RBPs), which play crucial roles in tumorigenesis, metastasis, and drug response in cancer by influencing gene expression and altering the processes of tumor initiation and progression. This review aims to summarize the recent advances in research on circRNA-protein interactions (CPIs) and discuss the functions and mode of action of CPIs at various stages of gene expression, including transcription, splicing, translation, and post-translational modifications in the context of cancer. Additionally, we explore the role of CPIs in tumor drug resistance to gain a deeper understanding of their potential applications in the development of new anti-cancer therapeutic approaches. |
| format | Article |
| id | doaj-art-bb633e7ec5c14036a7906726fdd0e839 |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-bb633e7ec5c14036a7906726fdd0e8392025-01-19T12:35:25ZengNature PortfolioCommunications Biology2399-36422025-01-018111910.1038/s42003-024-07383-zMechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancerNan Zhang0Xinjia Wang1Yu Li2Yiwei Lu3Chengcheng Sheng4Yumeng Sun5Ningye Ma6Yisheng Jiao7Shengjing Hospital of China Medical University, Obstetrics and Gynecology Department, NO36. Sanhao Street, Heping districtShengjing Hospital of China Medical University, Obstetrics and Gynecology Department, NO36. Sanhao Street, Heping districtShengjing Hospital of China Medical University, Obstetrics and Gynecology Department, NO36. Sanhao Street, Heping districtShengjing Hospital of China Medical University, Obstetrics and Gynecology Department, NO36. Sanhao Street, Heping districtShengjing Hospital of China Medical University, Obstetrics and Gynecology Department, NO36. Sanhao Street, Heping districtShengjing Hospital of China Medical University, Obstetrics and Gynecology Department, NO36. Sanhao Street, Heping districtShengjing Hospital of China Medical University, Obstetrics and Gynecology Department, NO36. Sanhao Street, Heping districtShengjing Hospital of China Medical University, Obstetrics and Gynecology Department, NO36. Sanhao Street, Heping districtAbstract Circular RNAs (circRNAs) have garnered substantial attention due to their distinctive circular structure and gene regulatory functions, establishing them as a significant class of functional non-coding RNAs in eukaryotes. Studies have demonstrated that circRNAs can interact with RNA-binding proteins (RBPs), which play crucial roles in tumorigenesis, metastasis, and drug response in cancer by influencing gene expression and altering the processes of tumor initiation and progression. This review aims to summarize the recent advances in research on circRNA-protein interactions (CPIs) and discuss the functions and mode of action of CPIs at various stages of gene expression, including transcription, splicing, translation, and post-translational modifications in the context of cancer. Additionally, we explore the role of CPIs in tumor drug resistance to gain a deeper understanding of their potential applications in the development of new anti-cancer therapeutic approaches.https://doi.org/10.1038/s42003-024-07383-z |
| spellingShingle | Nan Zhang Xinjia Wang Yu Li Yiwei Lu Chengcheng Sheng Yumeng Sun Ningye Ma Yisheng Jiao Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer Communications Biology |
| title | Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer |
| title_full | Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer |
| title_fullStr | Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer |
| title_full_unstemmed | Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer |
| title_short | Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer |
| title_sort | mechanisms and therapeutic implications of gene expression regulation by circrna protein interactions in cancer |
| url | https://doi.org/10.1038/s42003-024-07383-z |
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