Tumor necrosis factor-α/interleukin-10 balance in normal and cystic fibrosis children
Background: The balance between tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) is important for immune homeostasis maintenance. Exuberant production of TNF-α contributes to overwhelming inflammatory response and tissue damage. But, commonly, increase in TNF-α is counterbalanced by simult...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2001-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629350123387 |
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| _version_ | 1832563658431922176 |
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| author | Galina V. Shmarina Alexander L. Pukhalsky Svetlana N. Kokarovtseva Daria A. Pukhalskaya Lidia A. Shabalova Nikolai I. Kapranov Natalia J. Kashirskaja |
| author_facet | Galina V. Shmarina Alexander L. Pukhalsky Svetlana N. Kokarovtseva Daria A. Pukhalskaya Lidia A. Shabalova Nikolai I. Kapranov Natalia J. Kashirskaja |
| author_sort | Galina V. Shmarina |
| collection | DOAJ |
| description | Background: The balance between tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) is important for immune homeostasis maintenance. Exuberant production of TNF-α contributes to overwhelming inflammatory response and tissue damage. But, commonly, increase in TNF-α is counterbalanced by simultaneous synthesis of an anti-inflammatory cytokine IL-10, which suppresses production of many activating and regulatory mediators. |
| format | Article |
| id | doaj-art-bb5f5edb3eb748abbf4b11dcd9d6308b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-bb5f5edb3eb748abbf4b11dcd9d6308b2025-02-03T01:13:02ZengWileyMediators of Inflammation0962-93511466-18612001-01-0110419119710.1080/09629350123387Tumor necrosis factor-α/interleukin-10 balance in normal and cystic fibrosis childrenGalina V. Shmarina0Alexander L. Pukhalsky1Svetlana N. Kokarovtseva2Daria A. Pukhalskaya3Lidia A. Shabalova4Nikolai I. Kapranov5Natalia J. Kashirskaja6Laboratory of Immunogenetics, Research Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, RussiaLaboratory of Immunogenetics, Research Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, RussiaLaboratory of Immunogenetics, Research Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, RussiaLaboratory of Immunogenetics, Research Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, RussiaDepartment of Cystic Fibrosis, Research Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, RussiaDepartment of Cystic Fibrosis, Research Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, RussiaDepartment of Cystic Fibrosis, Research Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, RussiaBackground: The balance between tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) is important for immune homeostasis maintenance. Exuberant production of TNF-α contributes to overwhelming inflammatory response and tissue damage. But, commonly, increase in TNF-α is counterbalanced by simultaneous synthesis of an anti-inflammatory cytokine IL-10, which suppresses production of many activating and regulatory mediators.http://dx.doi.org/10.1080/09629350123387 |
| spellingShingle | Galina V. Shmarina Alexander L. Pukhalsky Svetlana N. Kokarovtseva Daria A. Pukhalskaya Lidia A. Shabalova Nikolai I. Kapranov Natalia J. Kashirskaja Tumor necrosis factor-α/interleukin-10 balance in normal and cystic fibrosis children Mediators of Inflammation |
| title | Tumor necrosis factor-α/interleukin-10 balance in normal and cystic fibrosis children |
| title_full | Tumor necrosis factor-α/interleukin-10 balance in normal and cystic fibrosis children |
| title_fullStr | Tumor necrosis factor-α/interleukin-10 balance in normal and cystic fibrosis children |
| title_full_unstemmed | Tumor necrosis factor-α/interleukin-10 balance in normal and cystic fibrosis children |
| title_short | Tumor necrosis factor-α/interleukin-10 balance in normal and cystic fibrosis children |
| title_sort | tumor necrosis factor α interleukin 10 balance in normal and cystic fibrosis children |
| url | http://dx.doi.org/10.1080/09629350123387 |
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