Tumor necrosis factor-α/interleukin-10 balance in normal and cystic fibrosis children

Tumor necrosis factor-α/interleukin-10 balance in normal and cystic fibrosis children

Background: The balance between tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) is important for immune homeostasis maintenance. Exuberant production of TNF-α contributes to overwhelming inflammatory response and tissue damage. But, commonly, increase in TNF-α is counterbalanced by simult...

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Main Authors: Galina V. Shmarina, Alexander L. Pukhalsky, Svetlana N. Kokarovtseva, Daria A. Pukhalskaya, Lidia A. Shabalova, Nikolai I. Kapranov, Natalia J. Kashirskaja
Format: Article
Language:English
Published: Wiley 2001-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1080/09629350123387
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Summary:Background: The balance between tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) is important for immune homeostasis maintenance. Exuberant production of TNF-α contributes to overwhelming inflammatory response and tissue damage. But, commonly, increase in TNF-α is counterbalanced by simultaneous synthesis of an anti-inflammatory cytokine IL-10, which suppresses production of many activating and regulatory mediators.
ISSN:0962-9351
1466-1861

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