Topical antifungal bigels: Formulation, characterization and evaluation
Bigels with antifungal substances, ciclopirox olamine and terbinafine hydrochloride, were made of hydrogel (poloxamer 407 gel) and oleogel (polyethylene and liquid paraffin mixture). Prepared bigels were found physically stable at room temperature for six months and at least four months at 40 °C. Re...
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| Format: | Article |
| Language: | English |
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Sciendo
2018-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2018-0014 |
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| author | Mazurkeviciute Agne Ramanauskiene Kristina Ivaskiene Marija Grigonis Aidas Briedis Vitalis |
| author_facet | Mazurkeviciute Agne Ramanauskiene Kristina Ivaskiene Marija Grigonis Aidas Briedis Vitalis |
| author_sort | Mazurkeviciute Agne |
| collection | DOAJ |
| description | Bigels with antifungal substances, ciclopirox olamine and terbinafine hydrochloride, were made of hydrogel (poloxamer 407 gel) and oleogel (polyethylene and liquid paraffin mixture). Prepared bigels were found physically stable at room temperature for six months and at least four months at 40 °C. Released amount of drug decreased when oleogel concentration in the formulation increased. Release test results depended on the insertion place of active substances. The amount of released substance was highest when ciclopirox olamine was incorporated in both phases in an equal quantity, and terbinafine hydrochloride in oleogel or in hydrogel. All formulations showed great inhibition of Microsporum canis. Thus, bigels with ciclopirox olamine and terbinafine hydrochloride are a promising dosage form for topical use. |
| format | Article |
| id | doaj-art-bb5cb39fb5eb427ead63b3b7f8ffa5c3 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-bb5cb39fb5eb427ead63b3b7f8ffa5c32025-02-02T00:31:54ZengSciendoActa Pharmaceutica1846-95582018-06-0168222323310.2478/acph-2018-0014acph-2018-0014Topical antifungal bigels: Formulation, characterization and evaluationMazurkeviciute Agne0Ramanauskiene Kristina1Ivaskiene Marija2Grigonis Aidas3Briedis Vitalis4Department of Clinical Pharmacy Faculty of Pharmacy, Lithuanian University of Health Sciences, 50161Kaunas, LithuaniaDepartment of Clinical Pharmacy Faculty of Pharmacy, Lithuanian University of Health Sciences, 50161Kaunas, LithuaniaDepartment of Non-infectious Diseases, Faculty of Veterinary Medicine, Veterinary Academy Lithuanian University of Health Science, 47181Kaunas, LithuaniaDepartment of Non-infectious Diseases, Faculty of Veterinary Medicine, Veterinary Academy Lithuanian University of Health Science, 47181Kaunas, LithuaniaDepartment of Clinical Pharmacy Faculty of Pharmacy, Lithuanian University of Health Sciences, 50161Kaunas, LithuaniaBigels with antifungal substances, ciclopirox olamine and terbinafine hydrochloride, were made of hydrogel (poloxamer 407 gel) and oleogel (polyethylene and liquid paraffin mixture). Prepared bigels were found physically stable at room temperature for six months and at least four months at 40 °C. Released amount of drug decreased when oleogel concentration in the formulation increased. Release test results depended on the insertion place of active substances. The amount of released substance was highest when ciclopirox olamine was incorporated in both phases in an equal quantity, and terbinafine hydrochloride in oleogel or in hydrogel. All formulations showed great inhibition of Microsporum canis. Thus, bigels with ciclopirox olamine and terbinafine hydrochloride are a promising dosage form for topical use.https://doi.org/10.2478/acph-2018-0014bigelciclopirox olamineterbinafine hydrochloridepoloxamer 407antifungalmicrosporum canis |
| spellingShingle | Mazurkeviciute Agne Ramanauskiene Kristina Ivaskiene Marija Grigonis Aidas Briedis Vitalis Topical antifungal bigels: Formulation, characterization and evaluation Acta Pharmaceutica bigel ciclopirox olamine terbinafine hydrochloride poloxamer 407 antifungal microsporum canis |
| title | Topical antifungal bigels: Formulation, characterization and evaluation |
| title_full | Topical antifungal bigels: Formulation, characterization and evaluation |
| title_fullStr | Topical antifungal bigels: Formulation, characterization and evaluation |
| title_full_unstemmed | Topical antifungal bigels: Formulation, characterization and evaluation |
| title_short | Topical antifungal bigels: Formulation, characterization and evaluation |
| title_sort | topical antifungal bigels formulation characterization and evaluation |
| topic | bigel ciclopirox olamine terbinafine hydrochloride poloxamer 407 antifungal microsporum canis |
| url | https://doi.org/10.2478/acph-2018-0014 |
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