Humoral Acute Rejection in a Kidney Transplant Recipient with Idiopathic Thrombocytopenic Purpura
A 47-year-old male was diagnosed with chronic kidney disease (CKD) in 2011; idiopathic thrombocytopenic purpura (ITP) was also diagnosed in 2011 refractory to medical treatment and finally treated with splenectomy (2017) without relapses since that date, 5 blood transfusions, and 4 platelet apheresi...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2021/9933354 |
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| author | Ana Paola Rico-Portillo José Ignacio Cerrillos-Gutierrez Jorge Andrade-Sierra Alfredo Gutiérrez-Govea Enrique Rojas-Campos Claudia Alejandra Mendoza-Cerpa Benjamín Gómez-Navarro |
| author_facet | Ana Paola Rico-Portillo José Ignacio Cerrillos-Gutierrez Jorge Andrade-Sierra Alfredo Gutiérrez-Govea Enrique Rojas-Campos Claudia Alejandra Mendoza-Cerpa Benjamín Gómez-Navarro |
| author_sort | Ana Paola Rico-Portillo |
| collection | DOAJ |
| description | A 47-year-old male was diagnosed with chronic kidney disease (CKD) in 2011; idiopathic thrombocytopenic purpura (ITP) was also diagnosed in 2011 refractory to medical treatment and finally treated with splenectomy (2017) without relapses since that date, 5 blood transfusions, and 4 platelet apheresis in 2017. Renal transplant from a living related donor (brother), ABO compatible, crossmatch were negative, sharing 1 haplotype. Donor-specific anti-HLA antibody was negative. Graft function was stable until the 5th day and graft biopsy on the 6th day; thrombotic microangiopathy (TMA), C4D negative and inflammatory infiltration of polymorphonuclear leukocytes inside peritubular capillary, and anti-MICA antibodies were positive. The treatment used were plasmapheresis, intravenous immunoglobulin, and rituximab. Serum creatinine began to decrease since the 14th day, and by day 33, post-RT graft function was restored. |
| format | Article |
| id | doaj-art-bb4c5d6087a543af8adfad60ad998b1d |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-bb4c5d6087a543af8adfad60ad998b1d2025-02-03T01:21:27ZengWileyCase Reports in Transplantation2090-69432090-69512021-01-01202110.1155/2021/99333549933354Humoral Acute Rejection in a Kidney Transplant Recipient with Idiopathic Thrombocytopenic PurpuraAna Paola Rico-Portillo0José Ignacio Cerrillos-Gutierrez1Jorge Andrade-Sierra2Alfredo Gutiérrez-Govea3Enrique Rojas-Campos4Claudia Alejandra Mendoza-Cerpa5Benjamín Gómez-Navarro6Departamento de Nefrología y Trasplantes, UMAE, Hospital de Especialidades, CMNO, IMSS, Guadalajara, Jalisco, MexicoDepartamento de Nefrología y Trasplantes, UMAE, Hospital de Especialidades, CMNO, IMSS, Guadalajara, Jalisco, MexicoDepartamento de Nefrología y Trasplantes, UMAE, Hospital de Especialidades, CMNO, IMSS, Guadalajara, Jalisco, MexicoDepartamento de Nefrología y Trasplantes, UMAE, Hospital de Especialidades, CMNO, IMSS, Guadalajara, Jalisco, MexicoUnidad de Investigación Médica en Enfermedades Renales UMAE, Hospital de Especialidades, CMNO, IMSS, Guadalajara, Jalisco, MexicoDepartamento de Anatomía Patológica UMAE, Hospital de Especialidades, CMNO, IMSS, Guadalajara, Jalisco, MexicoDepartamento de Nefrología y Trasplantes, UMAE, Hospital de Especialidades, CMNO, IMSS, Guadalajara, Jalisco, MexicoA 47-year-old male was diagnosed with chronic kidney disease (CKD) in 2011; idiopathic thrombocytopenic purpura (ITP) was also diagnosed in 2011 refractory to medical treatment and finally treated with splenectomy (2017) without relapses since that date, 5 blood transfusions, and 4 platelet apheresis in 2017. Renal transplant from a living related donor (brother), ABO compatible, crossmatch were negative, sharing 1 haplotype. Donor-specific anti-HLA antibody was negative. Graft function was stable until the 5th day and graft biopsy on the 6th day; thrombotic microangiopathy (TMA), C4D negative and inflammatory infiltration of polymorphonuclear leukocytes inside peritubular capillary, and anti-MICA antibodies were positive. The treatment used were plasmapheresis, intravenous immunoglobulin, and rituximab. Serum creatinine began to decrease since the 14th day, and by day 33, post-RT graft function was restored.http://dx.doi.org/10.1155/2021/9933354 |
| spellingShingle | Ana Paola Rico-Portillo José Ignacio Cerrillos-Gutierrez Jorge Andrade-Sierra Alfredo Gutiérrez-Govea Enrique Rojas-Campos Claudia Alejandra Mendoza-Cerpa Benjamín Gómez-Navarro Humoral Acute Rejection in a Kidney Transplant Recipient with Idiopathic Thrombocytopenic Purpura Case Reports in Transplantation |
| title | Humoral Acute Rejection in a Kidney Transplant Recipient with Idiopathic Thrombocytopenic Purpura |
| title_full | Humoral Acute Rejection in a Kidney Transplant Recipient with Idiopathic Thrombocytopenic Purpura |
| title_fullStr | Humoral Acute Rejection in a Kidney Transplant Recipient with Idiopathic Thrombocytopenic Purpura |
| title_full_unstemmed | Humoral Acute Rejection in a Kidney Transplant Recipient with Idiopathic Thrombocytopenic Purpura |
| title_short | Humoral Acute Rejection in a Kidney Transplant Recipient with Idiopathic Thrombocytopenic Purpura |
| title_sort | humoral acute rejection in a kidney transplant recipient with idiopathic thrombocytopenic purpura |
| url | http://dx.doi.org/10.1155/2021/9933354 |
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