Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections
Type I interferons (IFN-I) are a group of related proteins that help regulate the activity of the immune system and play a key role in host defense against viral infections. Upon infection, the IFN-I are rapidly secreted and induce a wide range of effects that not only act upon innate immune cells b...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/1372494 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849685461989064704 |
|---|---|
| author | Patricio L. Acosta Alana B. Byrne Diego R. Hijano Laura B. Talarico |
| author_facet | Patricio L. Acosta Alana B. Byrne Diego R. Hijano Laura B. Talarico |
| author_sort | Patricio L. Acosta |
| collection | DOAJ |
| description | Type I interferons (IFN-I) are a group of related proteins that help regulate the activity of the immune system and play a key role in host defense against viral infections. Upon infection, the IFN-I are rapidly secreted and induce a wide range of effects that not only act upon innate immune cells but also modulate the adaptive immune system. While IFN-I and many IFN stimulated genes are well-known for their protective antiviral role, recent studies have associated them with potential pathogenic functions. In this review, we summarize the current knowledge regarding the complex effects of human IFN-I responses in respiratory as well as reemerging flavivirus infections of public health significance and the molecular mechanisms by which viral proteins antagonize the establishment of an antiviral host defense. Antiviral effects and immune modulation of IFN-stimulated genes is discussed in resisting and controlling pathogens. Understanding the mechanisms of these processes will be crucial in determining how viral replication can be effectively controlled and in developing safe and effective vaccines and novel therapeutic strategies. |
| format | Article |
| id | doaj-art-bb47f9e6c3fa477592d2ed00a43dad4d |
| institution | DOAJ |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-bb47f9e6c3fa477592d2ed00a43dad4d2025-08-20T03:23:07ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/13724941372494Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral InfectionsPatricio L. Acosta0Alana B. Byrne1Diego R. Hijano2Laura B. Talarico3Laboratorio de Investigaciones Infectológicas y Biología Molecular, Unidad de Infectología, Departamento de Medicina, Hospital de Niños Dr. Ricardo Gutiérrez, Buenos Aires (1425), ArgentinaLaboratorio de Investigaciones Infectológicas y Biología Molecular, Unidad de Infectología, Departamento de Medicina, Hospital de Niños Dr. Ricardo Gutiérrez, Buenos Aires (1425), ArgentinaDepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN 38105, USALaboratorio de Investigaciones Infectológicas y Biología Molecular, Unidad de Infectología, Departamento de Medicina, Hospital de Niños Dr. Ricardo Gutiérrez, Buenos Aires (1425), ArgentinaType I interferons (IFN-I) are a group of related proteins that help regulate the activity of the immune system and play a key role in host defense against viral infections. Upon infection, the IFN-I are rapidly secreted and induce a wide range of effects that not only act upon innate immune cells but also modulate the adaptive immune system. While IFN-I and many IFN stimulated genes are well-known for their protective antiviral role, recent studies have associated them with potential pathogenic functions. In this review, we summarize the current knowledge regarding the complex effects of human IFN-I responses in respiratory as well as reemerging flavivirus infections of public health significance and the molecular mechanisms by which viral proteins antagonize the establishment of an antiviral host defense. Antiviral effects and immune modulation of IFN-stimulated genes is discussed in resisting and controlling pathogens. Understanding the mechanisms of these processes will be crucial in determining how viral replication can be effectively controlled and in developing safe and effective vaccines and novel therapeutic strategies.http://dx.doi.org/10.1155/2020/1372494 |
| spellingShingle | Patricio L. Acosta Alana B. Byrne Diego R. Hijano Laura B. Talarico Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections Journal of Immunology Research |
| title | Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections |
| title_full | Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections |
| title_fullStr | Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections |
| title_full_unstemmed | Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections |
| title_short | Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections |
| title_sort | human type i interferon antiviral effects in respiratory and reemerging viral infections |
| url | http://dx.doi.org/10.1155/2020/1372494 |
| work_keys_str_mv | AT patriciolacosta humantypeiinterferonantiviraleffectsinrespiratoryandreemergingviralinfections AT alanabbyrne humantypeiinterferonantiviraleffectsinrespiratoryandreemergingviralinfections AT diegorhijano humantypeiinterferonantiviraleffectsinrespiratoryandreemergingviralinfections AT laurabtalarico humantypeiinterferonantiviraleffectsinrespiratoryandreemergingviralinfections |