Confirmatory Factor Analysis of the Motor Unified Parkinson’s Disease Rating Scale
The motor examination section of the unified Parkinson’s disease rating scale (UPDRS) is widely used in research but few studies have examined whether subscales exist that tap relatively distinct motor abnormalities. We analyzed data from 193 persons enrolled in a population-based study in Central C...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2012/719167 |
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| author | Stefanie D. Vassar Yvette M. Bordelon Ron D. Hays Natalie Diaz Rebecca Rausch Cherry Mao Barbara G. Vickrey |
| author_facet | Stefanie D. Vassar Yvette M. Bordelon Ron D. Hays Natalie Diaz Rebecca Rausch Cherry Mao Barbara G. Vickrey |
| author_sort | Stefanie D. Vassar |
| collection | DOAJ |
| description | The motor examination section of the unified Parkinson’s disease rating scale (UPDRS) is widely used in research but few studies have examined whether subscales exist that tap relatively distinct motor abnormalities. We analyzed data from 193 persons enrolled in a population-based study in Central California. Patients were examined after overnight PD medication washout (“OFF” state) and approximately one hour after taking medication (“ON” state). We performed confirmatory factor analysis of the UPDRS for OFF and ON state examinations; correlations, reliability, and relative validity of resulting subscales were evaluated. A model with five factors (gait/posture, tremor, rigidity, bradykinesia affecting the left extremities, bradykinesia affecting the right extremities) fit the data well, with similar results for OFF and ON states. Internal consistency reliability coefficients were 0.90 or higher for all subscales. The gait/posture subscale most strongly discriminated across levels of patient reported PD symptom severity and of how PD affects them on a daily basis. Compared to the right sided bradykinesia subscale, the left sided bradykinesia subscale had higher discrimination across levels of self-reported PD symptom severity and functional impairment. This supports motor UPDRS containing multiple subscales that can be analyzed separately and provide information distinct from the total score that may be useful in clinical studies. |
| format | Article |
| id | doaj-art-bb38c1ca03b54204933bc9223895d9b9 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-bb38c1ca03b54204933bc9223895d9b92025-02-03T01:04:52ZengWileyParkinson's Disease2090-80832042-00802012-01-01201210.1155/2012/719167719167Confirmatory Factor Analysis of the Motor Unified Parkinson’s Disease Rating ScaleStefanie D. Vassar0Yvette M. Bordelon1Ron D. Hays2Natalie Diaz3Rebecca Rausch4Cherry Mao5Barbara G. Vickrey6UCLA Department of Neurology, Box 951769, C109 RNRC, Los Angeles, CA 90095-1769, USAUCLA Department of Neurology, Box 951769, C109 RNRC, Los Angeles, CA 90095-1769, USAUCLA Division of General Internal Medicine and Health Services Research, Department of Medicine, Los Angeles, CA 90095, USADepartment of Neurology, Harbor-UCLA Medical Center, Torrance, CA 90502, USAUCLA Department of Neurology, Box 951769, C109 RNRC, Los Angeles, CA 90095-1769, USAUCLA Department of Neurology, Box 951769, C109 RNRC, Los Angeles, CA 90095-1769, USAUCLA Department of Neurology, Box 951769, C109 RNRC, Los Angeles, CA 90095-1769, USAThe motor examination section of the unified Parkinson’s disease rating scale (UPDRS) is widely used in research but few studies have examined whether subscales exist that tap relatively distinct motor abnormalities. We analyzed data from 193 persons enrolled in a population-based study in Central California. Patients were examined after overnight PD medication washout (“OFF” state) and approximately one hour after taking medication (“ON” state). We performed confirmatory factor analysis of the UPDRS for OFF and ON state examinations; correlations, reliability, and relative validity of resulting subscales were evaluated. A model with five factors (gait/posture, tremor, rigidity, bradykinesia affecting the left extremities, bradykinesia affecting the right extremities) fit the data well, with similar results for OFF and ON states. Internal consistency reliability coefficients were 0.90 or higher for all subscales. The gait/posture subscale most strongly discriminated across levels of patient reported PD symptom severity and of how PD affects them on a daily basis. Compared to the right sided bradykinesia subscale, the left sided bradykinesia subscale had higher discrimination across levels of self-reported PD symptom severity and functional impairment. This supports motor UPDRS containing multiple subscales that can be analyzed separately and provide information distinct from the total score that may be useful in clinical studies.http://dx.doi.org/10.1155/2012/719167 |
| spellingShingle | Stefanie D. Vassar Yvette M. Bordelon Ron D. Hays Natalie Diaz Rebecca Rausch Cherry Mao Barbara G. Vickrey Confirmatory Factor Analysis of the Motor Unified Parkinson’s Disease Rating Scale Parkinson's Disease |
| title | Confirmatory Factor Analysis of the Motor Unified Parkinson’s Disease Rating Scale |
| title_full | Confirmatory Factor Analysis of the Motor Unified Parkinson’s Disease Rating Scale |
| title_fullStr | Confirmatory Factor Analysis of the Motor Unified Parkinson’s Disease Rating Scale |
| title_full_unstemmed | Confirmatory Factor Analysis of the Motor Unified Parkinson’s Disease Rating Scale |
| title_short | Confirmatory Factor Analysis of the Motor Unified Parkinson’s Disease Rating Scale |
| title_sort | confirmatory factor analysis of the motor unified parkinson s disease rating scale |
| url | http://dx.doi.org/10.1155/2012/719167 |
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