Electrochemical Determination of Doxorubicin in the Presence of Dacarbazine Using MWCNTs/ZnO Nanocomposite Modified Disposable Screen-Printed Electrode
In the current work, the MWCNTs/ZnO nanocomposite was successfully synthesized using simple method. Then, FE-SEM, XRD, and EDX techniques were applied for morphological and structural characterization. Afterward, a sensitive voltammetric sensor based on modification of a screen-printed carbon electr...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/15/1/60 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588928799997952 |
|---|---|
| author | Somayeh Tajik Hadi Beitollahi Fariba Garkani Nejad Zahra Dourandish |
| author_facet | Somayeh Tajik Hadi Beitollahi Fariba Garkani Nejad Zahra Dourandish |
| author_sort | Somayeh Tajik |
| collection | DOAJ |
| description | In the current work, the MWCNTs/ZnO nanocomposite was successfully synthesized using simple method. Then, FE-SEM, XRD, and EDX techniques were applied for morphological and structural characterization. Afterward, a sensitive voltammetric sensor based on modification of a screen-printed carbon electrode (SPCE) using MWCNTs/ZnO nanocomposite was developed for the determination of doxorubicin in the presence of dacarbazine. To evaluate the electrochemical response of the MWCNTs/ZnO/SPCE towards doxorubicin, cyclic voltammetry (CV) was applied. The MWCNTs/ZnO nanocomposite showed a significant synergistic effect on the electrochemical response of the electrode for the redox reaction of doxorubicin. Also, the MWCNTs/ZnO/SPCE demonstrated an enhanced sensing platform for the quantification of doxorubicin, obtaining a detection limit (LOD) of 0.002 µM and a sensitivity of 0.0897 µA/µM, as determined by differential pulse voltammetry (DPV) within a linear range from 0.007 to 150.0 µM. Also, the MWCNTs/ZnO nanocomposite-modified SPCE showed high electrochemical activities towards the oxidation of doxorubicin and dacarbazine with peak-potential separation of 345 mV, which is sufficient for doxorubicin determination in the presence of dacarbazine. Also, the MWCNTs/ZnO nanocomposite-modified SPCE presented reproducible and stable responses to determine doxorubicin. Finally, the developed platform demonstrated a successful performance for doxorubicin and dacarbazine determination in real samples, with recovery in the range of 97.1% to 104.0% and relative standard deviation (RSD) from 1.8% to 3.5%. |
| format | Article |
| id | doaj-art-bb1ddba1f3fd46dfb355ea5f48e38480 |
| institution | Kabale University |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-bb1ddba1f3fd46dfb355ea5f48e384802025-01-24T13:25:36ZengMDPI AGBiosensors2079-63742025-01-011516010.3390/bios15010060Electrochemical Determination of Doxorubicin in the Presence of Dacarbazine Using MWCNTs/ZnO Nanocomposite Modified Disposable Screen-Printed ElectrodeSomayeh Tajik0Hadi Beitollahi1Fariba Garkani Nejad2Zahra Dourandish3Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman 76169-13555, IranEnvironment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman 76318-85356, IranEnvironment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman 76318-85356, IranEnvironment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman 76318-85356, IranIn the current work, the MWCNTs/ZnO nanocomposite was successfully synthesized using simple method. Then, FE-SEM, XRD, and EDX techniques were applied for morphological and structural characterization. Afterward, a sensitive voltammetric sensor based on modification of a screen-printed carbon electrode (SPCE) using MWCNTs/ZnO nanocomposite was developed for the determination of doxorubicin in the presence of dacarbazine. To evaluate the electrochemical response of the MWCNTs/ZnO/SPCE towards doxorubicin, cyclic voltammetry (CV) was applied. The MWCNTs/ZnO nanocomposite showed a significant synergistic effect on the electrochemical response of the electrode for the redox reaction of doxorubicin. Also, the MWCNTs/ZnO/SPCE demonstrated an enhanced sensing platform for the quantification of doxorubicin, obtaining a detection limit (LOD) of 0.002 µM and a sensitivity of 0.0897 µA/µM, as determined by differential pulse voltammetry (DPV) within a linear range from 0.007 to 150.0 µM. Also, the MWCNTs/ZnO nanocomposite-modified SPCE showed high electrochemical activities towards the oxidation of doxorubicin and dacarbazine with peak-potential separation of 345 mV, which is sufficient for doxorubicin determination in the presence of dacarbazine. Also, the MWCNTs/ZnO nanocomposite-modified SPCE presented reproducible and stable responses to determine doxorubicin. Finally, the developed platform demonstrated a successful performance for doxorubicin and dacarbazine determination in real samples, with recovery in the range of 97.1% to 104.0% and relative standard deviation (RSD) from 1.8% to 3.5%.https://www.mdpi.com/2079-6374/15/1/60MWCNTs/ZnO nanocompositedoxorubicindacarbazineelectrochemical sensorscreen-printed carbon electrodevoltammetric determination |
| spellingShingle | Somayeh Tajik Hadi Beitollahi Fariba Garkani Nejad Zahra Dourandish Electrochemical Determination of Doxorubicin in the Presence of Dacarbazine Using MWCNTs/ZnO Nanocomposite Modified Disposable Screen-Printed Electrode Biosensors MWCNTs/ZnO nanocomposite doxorubicin dacarbazine electrochemical sensor screen-printed carbon electrode voltammetric determination |
| title | Electrochemical Determination of Doxorubicin in the Presence of Dacarbazine Using MWCNTs/ZnO Nanocomposite Modified Disposable Screen-Printed Electrode |
| title_full | Electrochemical Determination of Doxorubicin in the Presence of Dacarbazine Using MWCNTs/ZnO Nanocomposite Modified Disposable Screen-Printed Electrode |
| title_fullStr | Electrochemical Determination of Doxorubicin in the Presence of Dacarbazine Using MWCNTs/ZnO Nanocomposite Modified Disposable Screen-Printed Electrode |
| title_full_unstemmed | Electrochemical Determination of Doxorubicin in the Presence of Dacarbazine Using MWCNTs/ZnO Nanocomposite Modified Disposable Screen-Printed Electrode |
| title_short | Electrochemical Determination of Doxorubicin in the Presence of Dacarbazine Using MWCNTs/ZnO Nanocomposite Modified Disposable Screen-Printed Electrode |
| title_sort | electrochemical determination of doxorubicin in the presence of dacarbazine using mwcnts zno nanocomposite modified disposable screen printed electrode |
| topic | MWCNTs/ZnO nanocomposite doxorubicin dacarbazine electrochemical sensor screen-printed carbon electrode voltammetric determination |
| url | https://www.mdpi.com/2079-6374/15/1/60 |
| work_keys_str_mv | AT somayehtajik electrochemicaldeterminationofdoxorubicininthepresenceofdacarbazineusingmwcntsznonanocompositemodifieddisposablescreenprintedelectrode AT hadibeitollahi electrochemicaldeterminationofdoxorubicininthepresenceofdacarbazineusingmwcntsznonanocompositemodifieddisposablescreenprintedelectrode AT faribagarkaninejad electrochemicaldeterminationofdoxorubicininthepresenceofdacarbazineusingmwcntsznonanocompositemodifieddisposablescreenprintedelectrode AT zahradourandish electrochemicaldeterminationofdoxorubicininthepresenceofdacarbazineusingmwcntsznonanocompositemodifieddisposablescreenprintedelectrode |