Comparing Efficacies of Biopsy and Rapid Urease Testing for H. Pylori at a Single Institution
Helicobacter pylori (H. pylori) infects>50% of the world’s population, leading to gastric cancer if left untreated. An estimated 26,000 gastric cancer cases will occur in the US in 2023, with 40% of cases becoming the primary cause of death. Invasive and noninvasive techniques are used to diagnos...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Advanced Gut & Microbiome Research |
| Online Access: | http://dx.doi.org/10.1155/2023/2749199 |
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| author | Kathleen Hill Aiden V. Ohning Jonathan P. Mallory Stella Self Christine M. G. Schammel Jenny Meredith John Reddic Patrick Kent Jenny B. Knight |
| author_facet | Kathleen Hill Aiden V. Ohning Jonathan P. Mallory Stella Self Christine M. G. Schammel Jenny Meredith John Reddic Patrick Kent Jenny B. Knight |
| author_sort | Kathleen Hill |
| collection | DOAJ |
| description | Helicobacter pylori (H. pylori) infects>50% of the world’s population, leading to gastric cancer if left untreated. An estimated 26,000 gastric cancer cases will occur in the US in 2023, with 40% of cases becoming the primary cause of death. Invasive and noninvasive techniques are used to diagnose H. pylori infection; however, controversy exists regarding the “gold standard” for diagnosis. We sought to evaluate the efficacy of H. pylori invasive detection methods: stained biopsy and rapid urease test (RUT) at a single institution. For the study, 200 patients (100 H. pylori + and 100 H. pylori -) from a single institution that underwent gastric biopsies were selected and retrospectively evaluated for H. pylori status. Demographics and clinicopathologic data were collected, including diagnostic tests performed, treatment, and outcomes. Histology and RUT were highly positively and negatively correlative; however, disparate results occurred in 7% of samples which was significant (p<0.001). Of those that were H. pylori positive, 60% had a posttreatment test completed. Gastric cancer developed in 3 patients (1.5%), all of whom were H. pylori positive. Histology and RUT testing yield similar results; therefore, there is no efficacious reason to run both tests on patients. Since histology has greater sensitivity (>95%) and the ability to identify other gastropathies, it should be considered the “gold standard,” for the identification of H. pylori. |
| format | Article |
| id | doaj-art-bb052d8c0d08400695604726a34b6d68 |
| institution | Kabale University |
| issn | 2755-1652 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Gut & Microbiome Research |
| spelling | doaj-art-bb052d8c0d08400695604726a34b6d682025-02-03T06:45:22ZengWileyAdvanced Gut & Microbiome Research2755-16522023-01-01202310.1155/2023/2749199Comparing Efficacies of Biopsy and Rapid Urease Testing for H. Pylori at a Single InstitutionKathleen Hill0Aiden V. Ohning1Jonathan P. Mallory2Stella Self3Christine M. G. Schammel4Jenny Meredith5John Reddic6Patrick Kent7Jenny B. Knight8University of South Carolina School of Medicine GreenvilleKenyon CollegeClemson UniversityDepartment of EpidemiologyDepartment of PathologyClinical MicrobiologyClinical ChemistryDepartment of Infectious DiseaseUniversity of South Carolina School of Medicine GreenvilleHelicobacter pylori (H. pylori) infects>50% of the world’s population, leading to gastric cancer if left untreated. An estimated 26,000 gastric cancer cases will occur in the US in 2023, with 40% of cases becoming the primary cause of death. Invasive and noninvasive techniques are used to diagnose H. pylori infection; however, controversy exists regarding the “gold standard” for diagnosis. We sought to evaluate the efficacy of H. pylori invasive detection methods: stained biopsy and rapid urease test (RUT) at a single institution. For the study, 200 patients (100 H. pylori + and 100 H. pylori -) from a single institution that underwent gastric biopsies were selected and retrospectively evaluated for H. pylori status. Demographics and clinicopathologic data were collected, including diagnostic tests performed, treatment, and outcomes. Histology and RUT were highly positively and negatively correlative; however, disparate results occurred in 7% of samples which was significant (p<0.001). Of those that were H. pylori positive, 60% had a posttreatment test completed. Gastric cancer developed in 3 patients (1.5%), all of whom were H. pylori positive. Histology and RUT testing yield similar results; therefore, there is no efficacious reason to run both tests on patients. Since histology has greater sensitivity (>95%) and the ability to identify other gastropathies, it should be considered the “gold standard,” for the identification of H. pylori.http://dx.doi.org/10.1155/2023/2749199 |
| spellingShingle | Kathleen Hill Aiden V. Ohning Jonathan P. Mallory Stella Self Christine M. G. Schammel Jenny Meredith John Reddic Patrick Kent Jenny B. Knight Comparing Efficacies of Biopsy and Rapid Urease Testing for H. Pylori at a Single Institution Advanced Gut & Microbiome Research |
| title | Comparing Efficacies of Biopsy and Rapid Urease Testing for H. Pylori at a Single Institution |
| title_full | Comparing Efficacies of Biopsy and Rapid Urease Testing for H. Pylori at a Single Institution |
| title_fullStr | Comparing Efficacies of Biopsy and Rapid Urease Testing for H. Pylori at a Single Institution |
| title_full_unstemmed | Comparing Efficacies of Biopsy and Rapid Urease Testing for H. Pylori at a Single Institution |
| title_short | Comparing Efficacies of Biopsy and Rapid Urease Testing for H. Pylori at a Single Institution |
| title_sort | comparing efficacies of biopsy and rapid urease testing for h pylori at a single institution |
| url | http://dx.doi.org/10.1155/2023/2749199 |
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