Very Early Severe Posttransplant Recurrent Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis after Kidney Transplantation: Two Case Reports
Successful kidney transplantation (KTx) in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) has been reported with excellent patient and graft survival rates. The recurrence of AAV in transplant recipients is rare, and its mechanisms of action are not clearly known. The...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2022/9740225 |
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| author | Reda Laamech Hamza Naciri-Bennani Diane Giovannini Johan Noble Bénédicte Janbon Paolo Malvezzi Thomas Jouve Lionel Rostaing |
| author_facet | Reda Laamech Hamza Naciri-Bennani Diane Giovannini Johan Noble Bénédicte Janbon Paolo Malvezzi Thomas Jouve Lionel Rostaing |
| author_sort | Reda Laamech |
| collection | DOAJ |
| description | Successful kidney transplantation (KTx) in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) has been reported with excellent patient and graft survival rates. The recurrence of AAV in transplant recipients is rare, and its mechanisms of action are not clearly known. The optimum time for KTx and the relevance of ANCA titer at the time of transplantation remain controversial. We report two cases of extremely rapid recurrent AAV after renal transplantation; both were still ANCA-positive at the time of transplantation, which led us to question the pathogenesis of ANCA antibodies in recurrence in a kidney allograft. Apheresis plus immunosuppressive therapies were ineffective in the first case and the patient became dialysis-dependent, whereas in the second case methylprednisone pulses plus rituximab infusions resulted in long-lasting remission. |
| format | Article |
| id | doaj-art-bb0123683fe948f29ad6f9c82beec2ee |
| institution | Kabale University |
| issn | 2090-665X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-bb0123683fe948f29ad6f9c82beec2ee2025-02-03T01:01:10ZengWileyCase Reports in Nephrology2090-665X2022-01-01202210.1155/2022/9740225Very Early Severe Posttransplant Recurrent Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis after Kidney Transplantation: Two Case ReportsReda Laamech0Hamza Naciri-Bennani1Diane Giovannini2Johan Noble3Bénédicte Janbon4Paolo Malvezzi5Thomas Jouve6Lionel Rostaing7Nephrology, Hemodialysis, Apheresis and Kidney Transplantation DepartmentNephrology, Hemodialysis, Apheresis and Kidney Transplantation DepartmentGrenoble Alpes UniversityNephrology, Hemodialysis, Apheresis and Kidney Transplantation DepartmentNephrology, Hemodialysis, Apheresis and Kidney Transplantation DepartmentNephrology, Hemodialysis, Apheresis and Kidney Transplantation DepartmentNephrology, Hemodialysis, Apheresis and Kidney Transplantation DepartmentNephrology, Hemodialysis, Apheresis and Kidney Transplantation DepartmentSuccessful kidney transplantation (KTx) in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) has been reported with excellent patient and graft survival rates. The recurrence of AAV in transplant recipients is rare, and its mechanisms of action are not clearly known. The optimum time for KTx and the relevance of ANCA titer at the time of transplantation remain controversial. We report two cases of extremely rapid recurrent AAV after renal transplantation; both were still ANCA-positive at the time of transplantation, which led us to question the pathogenesis of ANCA antibodies in recurrence in a kidney allograft. Apheresis plus immunosuppressive therapies were ineffective in the first case and the patient became dialysis-dependent, whereas in the second case methylprednisone pulses plus rituximab infusions resulted in long-lasting remission.http://dx.doi.org/10.1155/2022/9740225 |
| spellingShingle | Reda Laamech Hamza Naciri-Bennani Diane Giovannini Johan Noble Bénédicte Janbon Paolo Malvezzi Thomas Jouve Lionel Rostaing Very Early Severe Posttransplant Recurrent Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis after Kidney Transplantation: Two Case Reports Case Reports in Nephrology |
| title | Very Early Severe Posttransplant Recurrent Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis after Kidney Transplantation: Two Case Reports |
| title_full | Very Early Severe Posttransplant Recurrent Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis after Kidney Transplantation: Two Case Reports |
| title_fullStr | Very Early Severe Posttransplant Recurrent Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis after Kidney Transplantation: Two Case Reports |
| title_full_unstemmed | Very Early Severe Posttransplant Recurrent Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis after Kidney Transplantation: Two Case Reports |
| title_short | Very Early Severe Posttransplant Recurrent Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis after Kidney Transplantation: Two Case Reports |
| title_sort | very early severe posttransplant recurrent antineutrophil cytoplasmic antibody associated glomerulonephritis after kidney transplantation two case reports |
| url | http://dx.doi.org/10.1155/2022/9740225 |
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