GABAergic neurons in basal forebrain exert frequency-specific modulation on auditory cortex and enhance attentional selection of auditory stimuli
Abstract The basal forebrain (BF), in particular its cholinergic projections to cortex, has been implicated in regulation of attention in sensory systems. Here, we examine the role of GABAergic projections of the posterior nucleus basalis (pNB) and globus pallidus (GP) in attentional regulation in t...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07318-8 |
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| author | Kevin Thomas Hamid Azimi Davide Maggioni Mark Sanders Pilar Vaca Sánchez Michael A. Harvey Gregor Rainer |
| author_facet | Kevin Thomas Hamid Azimi Davide Maggioni Mark Sanders Pilar Vaca Sánchez Michael A. Harvey Gregor Rainer |
| author_sort | Kevin Thomas |
| collection | DOAJ |
| description | Abstract The basal forebrain (BF), in particular its cholinergic projections to cortex, has been implicated in regulation of attention in sensory systems. Here, we examine the role of GABAergic projections of the posterior nucleus basalis (pNB) and globus pallidus (GP) in attentional regulation in the auditory system. We employed a detection task where rats detected a narrow band target embedded in broad band noise, while optogenetically modulating GABAergic BF activity. We found that GABAergic BF modulation impacted target detection specifically close to perceptual threshold, consistent with a role in attentional modulation. We also present evidence for target frequency specificity of this modulation, including frequency selectivity and tonotopic organization of pNB/GP, as well as frequency band specific effects of optogenetics on behavioural target detection and on neural activity in auditory cortex and thalamus. Our findings highlight an important role of BF GABAergic neurons in modulating attention in the auditory pathway. |
| format | Article |
| id | doaj-art-bb00d265ea434fb2ac0ffe91e19f3adc |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-bb00d265ea434fb2ac0ffe91e19f3adc2025-02-02T12:37:25ZengNature PortfolioCommunications Biology2399-36422025-01-018111410.1038/s42003-024-07318-8GABAergic neurons in basal forebrain exert frequency-specific modulation on auditory cortex and enhance attentional selection of auditory stimuliKevin Thomas0Hamid Azimi1Davide Maggioni2Mark Sanders3Pilar Vaca Sánchez4Michael A. Harvey5Gregor Rainer6Section of Medicine, University of FribourgSection of Medicine, University of FribourgSection of Medicine, University of FribourgSection of Medicine, University of FribourgSection of Medicine, University of FribourgSection of Medicine, University of FribourgSection of Medicine, University of FribourgAbstract The basal forebrain (BF), in particular its cholinergic projections to cortex, has been implicated in regulation of attention in sensory systems. Here, we examine the role of GABAergic projections of the posterior nucleus basalis (pNB) and globus pallidus (GP) in attentional regulation in the auditory system. We employed a detection task where rats detected a narrow band target embedded in broad band noise, while optogenetically modulating GABAergic BF activity. We found that GABAergic BF modulation impacted target detection specifically close to perceptual threshold, consistent with a role in attentional modulation. We also present evidence for target frequency specificity of this modulation, including frequency selectivity and tonotopic organization of pNB/GP, as well as frequency band specific effects of optogenetics on behavioural target detection and on neural activity in auditory cortex and thalamus. Our findings highlight an important role of BF GABAergic neurons in modulating attention in the auditory pathway.https://doi.org/10.1038/s42003-024-07318-8 |
| spellingShingle | Kevin Thomas Hamid Azimi Davide Maggioni Mark Sanders Pilar Vaca Sánchez Michael A. Harvey Gregor Rainer GABAergic neurons in basal forebrain exert frequency-specific modulation on auditory cortex and enhance attentional selection of auditory stimuli Communications Biology |
| title | GABAergic neurons in basal forebrain exert frequency-specific modulation on auditory cortex and enhance attentional selection of auditory stimuli |
| title_full | GABAergic neurons in basal forebrain exert frequency-specific modulation on auditory cortex and enhance attentional selection of auditory stimuli |
| title_fullStr | GABAergic neurons in basal forebrain exert frequency-specific modulation on auditory cortex and enhance attentional selection of auditory stimuli |
| title_full_unstemmed | GABAergic neurons in basal forebrain exert frequency-specific modulation on auditory cortex and enhance attentional selection of auditory stimuli |
| title_short | GABAergic neurons in basal forebrain exert frequency-specific modulation on auditory cortex and enhance attentional selection of auditory stimuli |
| title_sort | gabaergic neurons in basal forebrain exert frequency specific modulation on auditory cortex and enhance attentional selection of auditory stimuli |
| url | https://doi.org/10.1038/s42003-024-07318-8 |
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