The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic Disorders
The combination of obesity and type 2 diabetes is a serious health problem, which is projected to afflict 300 million people worldwide by 2020. Both clinical and translational laboratory studies have demonstrated that chronic inflammation is associated with obesity and obesity-related conditions suc...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/678627 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553007339798528 |
|---|---|
| author | Elisa Benetti Fausto Chiazza Nimesh S. A. Patel Massimo Collino |
| author_facet | Elisa Benetti Fausto Chiazza Nimesh S. A. Patel Massimo Collino |
| author_sort | Elisa Benetti |
| collection | DOAJ |
| description | The combination of obesity and type 2 diabetes is a serious health problem, which is projected to afflict 300 million people worldwide by 2020. Both clinical and translational laboratory studies have demonstrated that chronic inflammation is associated with obesity and obesity-related conditions such as insulin resistance. However, the precise etiopathogenetic mechanisms linking obesity to diabetes remain to be elucidated, and the pathways that mediate this phenomenon are not fully characterized. One of the most recently identified signaling pathways, whose activation seems to affect many metabolic disorders, is the “inflammasome,” a multiprotein complex composed of NLRP3 (nucleotide-binding domain and leucine-rich repeat protein 3), ASC (apoptosis-associated speck-like protein containing a CARD), and procaspase-1. NLRP3 inflammasome activation leads to the processing and secretion of the proinflammatory cytokines interleukin- (IL-) 1β and IL-18. The goal of this paper is to review new insights on the effects of the NLRP3 inflammasome activation in the complex mechanisms of crosstalk between different organs, for a better understanding of the role of chronic inflammation in metabolic disease pathogenesis. We will provide here a perspective on the current research on NLRP3 inflammasome, which may represent an innovative therapeutic target to reverse the detrimental metabolic consequences of the metabolic inflammation. |
| format | Article |
| id | doaj-art-baf04577ee2e473eb71f34f592d84e10 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-baf04577ee2e473eb71f34f592d84e102025-02-03T05:57:11ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/678627678627The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic DisordersElisa Benetti0Fausto Chiazza1Nimesh S. A. Patel2Massimo Collino3Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Torino, ItalyDepartment of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Torino, ItalyQueen Mary University of London, The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London EC1M 6BQ, UKDepartment of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Torino, ItalyThe combination of obesity and type 2 diabetes is a serious health problem, which is projected to afflict 300 million people worldwide by 2020. Both clinical and translational laboratory studies have demonstrated that chronic inflammation is associated with obesity and obesity-related conditions such as insulin resistance. However, the precise etiopathogenetic mechanisms linking obesity to diabetes remain to be elucidated, and the pathways that mediate this phenomenon are not fully characterized. One of the most recently identified signaling pathways, whose activation seems to affect many metabolic disorders, is the “inflammasome,” a multiprotein complex composed of NLRP3 (nucleotide-binding domain and leucine-rich repeat protein 3), ASC (apoptosis-associated speck-like protein containing a CARD), and procaspase-1. NLRP3 inflammasome activation leads to the processing and secretion of the proinflammatory cytokines interleukin- (IL-) 1β and IL-18. The goal of this paper is to review new insights on the effects of the NLRP3 inflammasome activation in the complex mechanisms of crosstalk between different organs, for a better understanding of the role of chronic inflammation in metabolic disease pathogenesis. We will provide here a perspective on the current research on NLRP3 inflammasome, which may represent an innovative therapeutic target to reverse the detrimental metabolic consequences of the metabolic inflammation.http://dx.doi.org/10.1155/2013/678627 |
| spellingShingle | Elisa Benetti Fausto Chiazza Nimesh S. A. Patel Massimo Collino The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic Disorders Mediators of Inflammation |
| title | The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic Disorders |
| title_full | The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic Disorders |
| title_fullStr | The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic Disorders |
| title_full_unstemmed | The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic Disorders |
| title_short | The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic Disorders |
| title_sort | nlrp3 inflammasome as a novel player of the intercellular crosstalk in metabolic disorders |
| url | http://dx.doi.org/10.1155/2013/678627 |
| work_keys_str_mv | AT elisabenetti thenlrp3inflammasomeasanovelplayeroftheintercellularcrosstalkinmetabolicdisorders AT faustochiazza thenlrp3inflammasomeasanovelplayeroftheintercellularcrosstalkinmetabolicdisorders AT nimeshsapatel thenlrp3inflammasomeasanovelplayeroftheintercellularcrosstalkinmetabolicdisorders AT massimocollino thenlrp3inflammasomeasanovelplayeroftheintercellularcrosstalkinmetabolicdisorders AT elisabenetti nlrp3inflammasomeasanovelplayeroftheintercellularcrosstalkinmetabolicdisorders AT faustochiazza nlrp3inflammasomeasanovelplayeroftheintercellularcrosstalkinmetabolicdisorders AT nimeshsapatel nlrp3inflammasomeasanovelplayeroftheintercellularcrosstalkinmetabolicdisorders AT massimocollino nlrp3inflammasomeasanovelplayeroftheintercellularcrosstalkinmetabolicdisorders |