Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord.

Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord.

Adaptor protein (AP) complexes regulate clathrin-coated vesicle assembly, protein cargo sorting, and vesicular trafficking between organelles in eukaryotic cells. Because disruption of the various subunits of the AP complexes is embryonic lethal in the majority of cases, characterization of their fu...

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Main Authors: Alexandre Montpetit, Stéphanie Côté, Edna Brustein, Christian A Drouin, Line Lapointe, Michèle Boudreau, Caroline Meloche, Régen Drouin, Thomas J Hudson, Pierre Drapeau, Patrick Cossette
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-12-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000296&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000296&type=printable

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