Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis
Acute limb ischemia (ALI) is rarely observed in young populations. The hypercoagulable state is a notable cause of ALI other than artery disease progression and cardiac embolization. A hypercoagulable state occurs in essential thrombocytosis because of the overproduction of hematopoietic cells secon...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2021/2563578 |
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| _version_ | 1832566364514025472 |
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| author | Johanes Nugroho Ruth Gunadi |
| author_facet | Johanes Nugroho Ruth Gunadi |
| author_sort | Johanes Nugroho |
| collection | DOAJ |
| description | Acute limb ischemia (ALI) is rarely observed in young populations. The hypercoagulable state is a notable cause of ALI other than artery disease progression and cardiac embolization. A hypercoagulable state occurs in essential thrombocytosis because of the overproduction of hematopoietic cells secondary to the mutation of the JAK2, CALR, or MPL genes. We report a rare case of a 37-year-old woman presenting with Rutherford IIA ALI in the left lower extremity. Laboratory data revealed she had a platelet count reaching up to 1.38 mil/μL, with other blood profiles being normal. A JAK2 mutation examination was later performed and proved positive. After careful management with catheter-directed thrombolysis, surgical thrombectomy, and cytoreductive therapy using hydroxyurea, the symptoms subsided and eventually restored the patient to physical activity in less than one month. |
| format | Article |
| id | doaj-art-bae05b528f3c4b7895580a64408909ac |
| institution | Kabale University |
| issn | 2090-6412 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-bae05b528f3c4b7895580a64408909ac2025-02-03T01:04:21ZengWileyCase Reports in Cardiology2090-64122021-01-01202110.1155/2021/2563578Acute Limb Ischemia in the Young: A Rare Case of Essential ThrombocytosisJohanes Nugroho0Ruth Gunadi1Department of Cardiology and Vascular MedicineDr. Soetomo General HospitalAcute limb ischemia (ALI) is rarely observed in young populations. The hypercoagulable state is a notable cause of ALI other than artery disease progression and cardiac embolization. A hypercoagulable state occurs in essential thrombocytosis because of the overproduction of hematopoietic cells secondary to the mutation of the JAK2, CALR, or MPL genes. We report a rare case of a 37-year-old woman presenting with Rutherford IIA ALI in the left lower extremity. Laboratory data revealed she had a platelet count reaching up to 1.38 mil/μL, with other blood profiles being normal. A JAK2 mutation examination was later performed and proved positive. After careful management with catheter-directed thrombolysis, surgical thrombectomy, and cytoreductive therapy using hydroxyurea, the symptoms subsided and eventually restored the patient to physical activity in less than one month.http://dx.doi.org/10.1155/2021/2563578 |
| spellingShingle | Johanes Nugroho Ruth Gunadi Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis Case Reports in Cardiology |
| title | Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis |
| title_full | Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis |
| title_fullStr | Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis |
| title_full_unstemmed | Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis |
| title_short | Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis |
| title_sort | acute limb ischemia in the young a rare case of essential thrombocytosis |
| url | http://dx.doi.org/10.1155/2021/2563578 |
| work_keys_str_mv | AT johanesnugroho acutelimbischemiaintheyoungararecaseofessentialthrombocytosis AT ruthgunadi acutelimbischemiaintheyoungararecaseofessentialthrombocytosis |