Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older
Objective. To investigate the association between the hypertriglyceridemic waist (HTGW) phenotype and prediabetes in Chinese adults aged 40 years and older. Methods. 12757 adults (4101 men and 8656 women) without diabetes or cardiovascular and cerebrovascular diseases, free of using lipid-modified a...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/1031939 |
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| author | Kun Zhao Shan-Shan Yang Hai-Bin Wang Kang Chen Zhao-Hui Lu Yi-Ming Mu |
| author_facet | Kun Zhao Shan-Shan Yang Hai-Bin Wang Kang Chen Zhao-Hui Lu Yi-Ming Mu |
| author_sort | Kun Zhao |
| collection | DOAJ |
| description | Objective. To investigate the association between the hypertriglyceridemic waist (HTGW) phenotype and prediabetes in Chinese adults aged 40 years and older. Methods. 12757 adults (4101 men and 8656 women) without diabetes or cardiovascular and cerebrovascular diseases, free of using lipid-modified agents, were enrolled in this cross-sectional study. The HTGW phenotype was defined as elevated serum triglyceride concentrations and enlarged waist circumference. A two-hour post 75 g oral glucose tolerance test was performed in all participants. Multiple logistic regression analysis was used to evaluate the relationship of the HTGW phenotype with prediabetes. Results. Individuals with the HTGW phenotype had a higher adjusted odds ratio (OR: 1.70; 95% CI: 1.48–1.95) of prediabetes than those without the phenotype. There existed a strong relationship of the HTGW phenotype with impaired glucose tolerance (IGT) (OR: 1.83; 95% CI: 1.57–2.13), but not with impaired fasting glucose (IFG) (OR: 0.87; 95% CI: 0.65–1.17). Only women with the HTGW phenotype are significantly associated with the combined IFG and IGT (OR: 1.83; 95% CI: 1.28–2.62). Conclusions. The HTGW phenotype was a useful risk indicator and a practical screening tool to benefit in the early diagnosis and intervention for prediabetes, particularly for IGT and the combined IFG and IGT. |
| format | Article |
| id | doaj-art-bad3b6a0e10d472d81780a60051e3558 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-bad3b6a0e10d472d81780a60051e35582025-02-03T06:00:02ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/10319391031939Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and OlderKun Zhao0Shan-Shan Yang1Hai-Bin Wang2Kang Chen3Zhao-Hui Lu4Yi-Ming Mu5Department of Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaInstitute of Geriatrics, Beijing Key Laboratory of Ageing and Geriatrics, and State Key Laboratory of Kidney Disease, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaDepartment of Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaDepartment of Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaDepartment of Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaDepartment of Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, ChinaObjective. To investigate the association between the hypertriglyceridemic waist (HTGW) phenotype and prediabetes in Chinese adults aged 40 years and older. Methods. 12757 adults (4101 men and 8656 women) without diabetes or cardiovascular and cerebrovascular diseases, free of using lipid-modified agents, were enrolled in this cross-sectional study. The HTGW phenotype was defined as elevated serum triglyceride concentrations and enlarged waist circumference. A two-hour post 75 g oral glucose tolerance test was performed in all participants. Multiple logistic regression analysis was used to evaluate the relationship of the HTGW phenotype with prediabetes. Results. Individuals with the HTGW phenotype had a higher adjusted odds ratio (OR: 1.70; 95% CI: 1.48–1.95) of prediabetes than those without the phenotype. There existed a strong relationship of the HTGW phenotype with impaired glucose tolerance (IGT) (OR: 1.83; 95% CI: 1.57–2.13), but not with impaired fasting glucose (IFG) (OR: 0.87; 95% CI: 0.65–1.17). Only women with the HTGW phenotype are significantly associated with the combined IFG and IGT (OR: 1.83; 95% CI: 1.28–2.62). Conclusions. The HTGW phenotype was a useful risk indicator and a practical screening tool to benefit in the early diagnosis and intervention for prediabetes, particularly for IGT and the combined IFG and IGT.http://dx.doi.org/10.1155/2018/1031939 |
| spellingShingle | Kun Zhao Shan-Shan Yang Hai-Bin Wang Kang Chen Zhao-Hui Lu Yi-Ming Mu Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older Journal of Diabetes Research |
| title | Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older |
| title_full | Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older |
| title_fullStr | Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older |
| title_full_unstemmed | Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older |
| title_short | Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older |
| title_sort | association between the hypertriglyceridemic waist phenotype and prediabetes in chinese adults aged 40 years and older |
| url | http://dx.doi.org/10.1155/2018/1031939 |
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