Clopidogrel-Induced Neutropenia after Coronary Stenting: Is Cilostazol a Good Alternative?
Dual antiplatelet therapy with aspirin plus thienopyridines has become the standard treatment of patients undergoing coronary stenting. Clopidogrel has mostly replaced the use of ticlopidine due to its more favourable adverse event profile. However, also the use of clopidogrel is not without side ef...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/867964 |
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| author | Massimo Montalto Italo Porto Antonella Gallo Claudia Camaioni Roberta Della Bona Antonio Grieco Filippo Crea Raffaele Landolfi |
| author_facet | Massimo Montalto Italo Porto Antonella Gallo Claudia Camaioni Roberta Della Bona Antonio Grieco Filippo Crea Raffaele Landolfi |
| author_sort | Massimo Montalto |
| collection | DOAJ |
| description | Dual antiplatelet therapy with aspirin plus thienopyridines has become the standard treatment of patients undergoing coronary stenting. Clopidogrel has mostly replaced the use of ticlopidine due to its more favourable adverse event profile. However, also the use of clopidogrel is not without side effects. Clopidogrel major adverse events are represented by marrow suppression, manifesting with aplastic anaemia, thrombocytopenia and neutropenia. When clopidogrel toxicity occurs, there are few and unsubstantiated alternative treatments and thus, in these cases, medical decisions may be very difficult. We report a case of clopidogrel-induced bone marrow toxicity manifesting with severe neutropenia in a patient treated with multiple coronary stents and provide suggestions for an alternative treatment. |
| format | Article |
| id | doaj-art-bad2aec33ffe4dfbadb25feb27f5a673 |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-bad2aec33ffe4dfbadb25feb27f5a6732025-02-03T06:06:39ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322011-01-01201110.1155/2011/867964867964Clopidogrel-Induced Neutropenia after Coronary Stenting: Is Cilostazol a Good Alternative?Massimo Montalto0Italo Porto1Antonella Gallo2Claudia Camaioni3Roberta Della Bona4Antonio Grieco5Filippo Crea6Raffaele Landolfi7Institute of Internal Medicine, Catholic University of Rome, 00168 Rome, ItalyInstitute of Internal Medicine, Catholic University of Rome, 00168 Rome, ItalyInstitute of Internal Medicine, Catholic University of Rome, 00168 Rome, ItalyInstitute of Internal Medicine, Catholic University of Rome, 00168 Rome, ItalyInstitute of Internal Medicine, Catholic University of Rome, 00168 Rome, ItalyInstitute of Internal Medicine, Catholic University of Rome, 00168 Rome, ItalyInstitute of Internal Medicine, Catholic University of Rome, 00168 Rome, ItalyInstitute of Internal Medicine, Catholic University of Rome, 00168 Rome, ItalyDual antiplatelet therapy with aspirin plus thienopyridines has become the standard treatment of patients undergoing coronary stenting. Clopidogrel has mostly replaced the use of ticlopidine due to its more favourable adverse event profile. However, also the use of clopidogrel is not without side effects. Clopidogrel major adverse events are represented by marrow suppression, manifesting with aplastic anaemia, thrombocytopenia and neutropenia. When clopidogrel toxicity occurs, there are few and unsubstantiated alternative treatments and thus, in these cases, medical decisions may be very difficult. We report a case of clopidogrel-induced bone marrow toxicity manifesting with severe neutropenia in a patient treated with multiple coronary stents and provide suggestions for an alternative treatment.http://dx.doi.org/10.1155/2011/867964 |
| spellingShingle | Massimo Montalto Italo Porto Antonella Gallo Claudia Camaioni Roberta Della Bona Antonio Grieco Filippo Crea Raffaele Landolfi Clopidogrel-Induced Neutropenia after Coronary Stenting: Is Cilostazol a Good Alternative? International Journal of Vascular Medicine |
| title | Clopidogrel-Induced Neutropenia after Coronary Stenting: Is Cilostazol a Good Alternative? |
| title_full | Clopidogrel-Induced Neutropenia after Coronary Stenting: Is Cilostazol a Good Alternative? |
| title_fullStr | Clopidogrel-Induced Neutropenia after Coronary Stenting: Is Cilostazol a Good Alternative? |
| title_full_unstemmed | Clopidogrel-Induced Neutropenia after Coronary Stenting: Is Cilostazol a Good Alternative? |
| title_short | Clopidogrel-Induced Neutropenia after Coronary Stenting: Is Cilostazol a Good Alternative? |
| title_sort | clopidogrel induced neutropenia after coronary stenting is cilostazol a good alternative |
| url | http://dx.doi.org/10.1155/2011/867964 |
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