Lipodystrophy among HIV-Infected Patients Attending Care and Treatment Clinics in Dar es Salaam
Background. HIV infection and long-term HAART use are associated with metabolic and morphological changes. We assessed prevalence, types, and risk factors associated with lipodystrophy among HIV-infected adults attending CTC in Dar es Salaam, Tanzania. Methods. Analysis included 466 HIV-infected pat...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2017/3896539 |
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| author | Marina Njelekela Rose Mpembeni Alfa Muhihi Nzovu Ulenga Eric Aris Deodatus Kakoko |
| author_facet | Marina Njelekela Rose Mpembeni Alfa Muhihi Nzovu Ulenga Eric Aris Deodatus Kakoko |
| author_sort | Marina Njelekela |
| collection | DOAJ |
| description | Background. HIV infection and long-term HAART use are associated with metabolic and morphological changes. We assessed prevalence, types, and risk factors associated with lipodystrophy among HIV-infected adults attending CTC in Dar es Salaam, Tanzania. Methods. Analysis included 466 HIV-infected patients. Study protocol involved administration of structured questionnaire to collect sociodemographic and clinical information. Diagnosis of lipodystrophy was based on physician clinical assessment. Results. Lipodystrophy was present in 95 (20.4%) of the study participants, with lipoatrophy being the most common (49.5%) followed by mixed lipodystrophy (37.9%), and lipohypertrophy was the least prevalent (12.6%). Male gender, older age, long duration on HAART, and use of Stavudine containing regimen were associated with lipodystrophy (all p<0.05). The risk for lipodystrophy was 1.6 times (AOR = 1.66, 95% CI = 1.01–2.72) for male participants and 13.3 times (AOR = 13.3, 95% CI = 6.4–27.7) for those on HAART. Long duration on HAART and use of Stavudine containing regimen were also associated with increased risk for lipodystrophy. Lipodystrophy was associated with poor perception about own body image and decreased social interactions. Conclusions. Lipodystrophy is common among HIV-infected patients in Tanzania, especially among male patients and those on HAART. Regular screening, monitoring, and patient awareness are needed for early identification and appropriate management. |
| format | Article |
| id | doaj-art-baaa78a1e279484eb1ec7348f5085c73 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-baaa78a1e279484eb1ec7348f5085c732025-02-03T07:23:50ZengWileyAIDS Research and Treatment2090-12402090-12592017-01-01201710.1155/2017/38965393896539Lipodystrophy among HIV-Infected Patients Attending Care and Treatment Clinics in Dar es SalaamMarina Njelekela0Rose Mpembeni1Alfa Muhihi2Nzovu Ulenga3Eric Aris4Deodatus Kakoko5Department of Physiology, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, TanzaniaDepartment of Epidemiology and Biostatistics, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, TanzaniaManagement and Development for Health, Mwai Kibaki Road, Mikocheni, P.O. Box 79810, Dar es Salaam, TanzaniaManagement and Development for Health, Mwai Kibaki Road, Mikocheni, P.O. Box 79810, Dar es Salaam, TanzaniaManagement and Development for Health, Mwai Kibaki Road, Mikocheni, P.O. Box 79810, Dar es Salaam, TanzaniaDepartment of Behavioral Sciences, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, TanzaniaBackground. HIV infection and long-term HAART use are associated with metabolic and morphological changes. We assessed prevalence, types, and risk factors associated with lipodystrophy among HIV-infected adults attending CTC in Dar es Salaam, Tanzania. Methods. Analysis included 466 HIV-infected patients. Study protocol involved administration of structured questionnaire to collect sociodemographic and clinical information. Diagnosis of lipodystrophy was based on physician clinical assessment. Results. Lipodystrophy was present in 95 (20.4%) of the study participants, with lipoatrophy being the most common (49.5%) followed by mixed lipodystrophy (37.9%), and lipohypertrophy was the least prevalent (12.6%). Male gender, older age, long duration on HAART, and use of Stavudine containing regimen were associated with lipodystrophy (all p<0.05). The risk for lipodystrophy was 1.6 times (AOR = 1.66, 95% CI = 1.01–2.72) for male participants and 13.3 times (AOR = 13.3, 95% CI = 6.4–27.7) for those on HAART. Long duration on HAART and use of Stavudine containing regimen were also associated with increased risk for lipodystrophy. Lipodystrophy was associated with poor perception about own body image and decreased social interactions. Conclusions. Lipodystrophy is common among HIV-infected patients in Tanzania, especially among male patients and those on HAART. Regular screening, monitoring, and patient awareness are needed for early identification and appropriate management.http://dx.doi.org/10.1155/2017/3896539 |
| spellingShingle | Marina Njelekela Rose Mpembeni Alfa Muhihi Nzovu Ulenga Eric Aris Deodatus Kakoko Lipodystrophy among HIV-Infected Patients Attending Care and Treatment Clinics in Dar es Salaam AIDS Research and Treatment |
| title | Lipodystrophy among HIV-Infected Patients Attending Care and Treatment Clinics in Dar es Salaam |
| title_full | Lipodystrophy among HIV-Infected Patients Attending Care and Treatment Clinics in Dar es Salaam |
| title_fullStr | Lipodystrophy among HIV-Infected Patients Attending Care and Treatment Clinics in Dar es Salaam |
| title_full_unstemmed | Lipodystrophy among HIV-Infected Patients Attending Care and Treatment Clinics in Dar es Salaam |
| title_short | Lipodystrophy among HIV-Infected Patients Attending Care and Treatment Clinics in Dar es Salaam |
| title_sort | lipodystrophy among hiv infected patients attending care and treatment clinics in dar es salaam |
| url | http://dx.doi.org/10.1155/2017/3896539 |
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